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Naltrexone Disease Interactions

There are 2 disease interactions with naltrexone:

Major

Naltrexone (Includes naltrexone) ↔ hepatic dysfunction

Major Potential Hazard, High plausibility. Applies to: Liver Disease

The use of naltrexone is contraindicated in patients with active hepatitis or hepatic failure. Naltrexone has caused direct hepatocellular injury when administered at doses less than or equal to 5 times the recommended once daily 50 mg dose. Therapy with naltrexone should be administered cautiously in patients with active hepatic disease. Clinical monitoring of transaminase levels prior to and during naltrexone therapy is recommended.

References

  1. "Product Information. ReVia (naltrexone)." DuPont Pharmaceuticals, Wilmington, DE.
  2. Volpicelli JR, Volpicelli LA, Obrien CP "Medical management of alcohol dependence: clinical use and limitations of naltrexone treatment." Alcohol Alcohol 30 (1995): 789-98
  3. Verebey K, Volavka J, Mule SJ, Resnick RB "Naltrexone: disposition, metabolism, and effects after acute and chronic dosing." Clin Pharmacol Ther 20 (1976): 315-28
Moderate

Opiate antagonists (Includes naltrexone) ↔ hepatic/renal dysfunction

Moderate Potential Hazard, Moderate plausibility. Applies to: Renal Dysfunction, Liver Disease

Opiate antagonists are metabolized by the liver (naltrexone to an active metabolite) and eliminated by the kidney. Hepatic and renal impairment may reduce the metabolism and clearance of opiate antagonists. Dosage adjustment for single dose administration is not necessary, however, repeated doses in patients with hepatic and/or renal dysfunction may require adjustment.

References

  1. "Product Information. Revex (nalmefene)." Ohmeda Pharmaceutical Products Division, Liberty Corner, NJ.
  2. "Product Information. Narcan (naloxone)." DuPont Pharmaceuticals, Wilmington, DE.

Naltrexone drug interactions

There are 306 drug interactions with naltrexone

Naltrexone alcohol/food interactions

There is 1 alcohol/food interaction with naltrexone

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.