Comparing Methotrexate vs Tacrolimus
| Methotrexate Remove Methotrexate from your drug comparison | Tacrolimus Remove Tacrolimus from your drug comparison |
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| Methotrexate Remove Methotrexate from your drug comparison | Tacrolimus Remove Tacrolimus from your drug comparison | ||||||||||||||||
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Methotrexate may be considered for the treatment of psoriasis or rheumatoid arthritis if other treatments have failed. It may also be used in certain cancers. Side effects can be severe and... View more |
Prescribed for Organ Transplant - Rejection Prophylaxis, Organ Transplant - Rejection Reversal. May also be prescribed off label for Nephrotic Syndrome, Graft-versus-host disease, Crohn's Disease. |
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Prescription only |
Prescription only |
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Ratings & ReviewsRecent helpful reviews |
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6.7
For Rheumatoid Arthritis: I have been on 15mg then 20mg for two years. Then developed constant explosive diarrhea, dizziness, and confusion. Judged to be allergic, and told to stop the medication immediately. The symptoms continue...how long before it gets better? I am not taking anything for RA right now after a week off methotrexate. |
8.1
For Organ Transplant, Rejection Prophylaxis: I received a modified multi visceral transplant in 2008 due to a desmoid tumor, I had this surgery performed at U.P.M.C of Pittsburgh where I was blessed by God to have had amazing transplant doctors. I was on Prograf for the longest amount of time and had since been switched over to the generic. I had noticed for quite a while however that I do suffer from tremors and lately I have been having the feeling of eye twitching which is slightly annoying to me but I can not complain as without God and my medicine I would not be here to share this. I have heard of long term conditions down the road from others that I have come across and Lord willing that will not be my case, I have become diabetic. I hope this helps. For Organ Transplant, Rejection Prophylaxis: I have been using Tacrolimus for the past 2 years. Had a liver transplant on 1 Aug 2009, was on Prograf but I live in Kenya and it is difficult to find Prograf in the local market so I went generic. I started out on 6mg twice daily, I'm down to 4mg twice daily. There's been no difference for me between the Prograf and the generic version... but I have put on weight. |
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Drug Class |
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Side Effects |
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Commonly reported side effects include: increased liver enzymes. See the full methotrexate side effects document. |
Commonly reported side effects include: opportunistic infection, diabetes mellitus, infection, headache, hyperglycemia, hyperkalemia, increased blood urea nitrogen, increased serum creatinine, mental status changes, nephrotoxicity, sensation disorder, and tremor. See the full tacrolimus side effects document. |
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Pricing and Coupons* Prices are without insurance |
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View all methotrexate prices |
View all tacrolimus prices |
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Generic Availability |
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Yes (this medicine) |
Yes (this medicine) |
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Dosage Form(s) Available |
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Brand Names |
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| Methotrexate LPF Sodium, Otrexup, Rasuvo, RediTrex, Trexall, Xatmep | Astagraf XL, Envarsus XR, Prograf | ||||||||||||||||
Half LifeThe half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. |
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12 hours |
21.2 hours |
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CSA Schedule**View glossary of terms. |
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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Pregnancy Category |
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Category X
Not for use in pregnancy
See the full Pregnancy Warnings document. |
Category C
Risk cannot be ruled out
See the full Pregnancy Warnings document. |
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FDA Alerts |
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Drug Interactions |
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A total of 589 drugs are known to interact with methotrexate:
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A total of 731 drugs are known to interact with tacrolimus:
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Alcohol/Food/Lifestyle Interactions |
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Disease Interactions |
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First Approval Date |
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December 07, 1953 |
April 08, 1994 |
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WADA ClassView World Anti-Doping Agency classifications. |
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N/A |
N/A |
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More Information |
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Consumer Resources |
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Professional Resources |
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Related Treatment Guide |
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** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
For Rheumatoid Arthritis: I had taken MTX in past but it did not work out for me due to rash proplem caused by MTX so Doctor recommended Sulfasalazine and it worked out very good for about 4 years but the end of friendship came to us...Sulfasalazine was not effective anymore. I met a Doctor who practice natrual madicine also ER Dortor at the local hospital....He recommended 3 natrual Supplements for RA and pain( Turmeric, Wobenzym N, White Willow) and they are very effective (on me) and it is better than Chemical based medications. I have been off from those deadly medications for 5 months now.