Lithium Alternatives Compared
| Lithium | Vraylar (cariprazine) | Caplyta (lumateperone) |
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| Lithium | Vraylar (cariprazine) | Caplyta (lumateperone) |
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Prescription only
Lithium may be used to treat manic episodes associated with bipolar disorder; however, there is a fine line between too much and too little, and ongoing monitoring is needed to prevent lithium... View more |
Prescription only
Vraylar is an atypical antipsychotic that is effective for the treatment of schizophrenia and bipolar disorder. Vraylar is usually well-tolerated and less likely than some other antipsychotics to... View more |
Prescription only
Caplyta is an atypical antipsychotic that is used to treat adults with schizophrenia or depression associated with bipolar disorder. Sleepiness is the most common side effect and it should not be... View more |
Related suggestions Bipolar Disorder
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| More about Lithium | More about Vraylar (cariprazine) | More about Caplyta (lumateperone) | ||||||||||||||||||||||||
| Ratings & Reviews | ||||||||||||||||||||||||||
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Lithium has an average rating of 7.3 out of 10 from a total of 489 ratings on Drugs.com. 66% of reviewers reported a positive effect, while 20% reported a negative effect. |
Vraylar has an average rating of 6.0 out of 10 from a total of 518 ratings on Drugs.com. 49% of reviewers reported a positive effect, while 33% reported a negative effect. |
Caplyta has an average rating of 6.6 out of 10 from a total of 183 ratings on Drugs.com. 55% of reviewers reported a positive effect, while 29% reported a negative effect. |
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| Drug Class | ||||||||||||||||||||||||||
| Side Effects | ||||||||||||||||||||||||||
| Generic Availability | ||||||||||||||||||||||||||
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Lower cost generic |
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| Pricing and Coupons * Prices are without insurance | ||||||||||||||||||||||||||
View all Lithium prices |
View all Vraylar prices |
View all Caplyta prices |
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| Dosage Forms Available | ||||||||||||||||||||||||||
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| Brand Names | ||||||||||||||||||||||||||
| Lithium Carbonate ER, Lithobid |
N/A |
N/A |
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| Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. | ||||||||||||||||||||||||||
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29 hours |
504 hours |
18 hours |
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| CSA Schedule ** View glossary of terms | ||||||||||||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | ||||||||||||||||||||||||||
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Category D
Positive evidence of risk
See the full pregnancy warnings document. |
Summary unavailable. See the full pregnancy warnings document. |
Summary unavailable. See the full pregnancy warnings document. |
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| Drug Interactions | ||||||||||||||||||||||||||
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A total of 722 drugs are known to interact with Lithium:
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A total of 575 drugs are known to interact with Vraylar:
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A total of 602 drugs are known to interact with Caplyta:
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| Alcohol/Food/Lifestyle Interactions | ||||||||||||||||||||||||||
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| Disease Interactions | ||||||||||||||||||||||||||
| First Approval Date | ||||||||||||||||||||||||||
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April 06, 1970 |
September 17, 2015 |
December 20, 2019 |
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| WADA Class View World Anti-Doping Agency classifications. | ||||||||||||||||||||||||||
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N/A |
N/A |
N/A |
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| More Information | ||||||||||||||||||||||||||
| Patient resources | ||||||||||||||||||||||||||
| Professional Resources | ||||||||||||||||||||||||||
| Related Treatment Guide | ||||||||||||||||||||||||||
** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.