Comparing Hydroxyzine vs Promethazine

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Hydroxyzine	Promethazine	Enter another drug to compare

Hydroxyzine

Promethazine

Prescription only

Hydroxyzine may be used to relieve anxiety or itching; however, it causes sedation so can affect a person's ability to drive or operate machinery. It should not be used during pregnancy or while... View more

Prescription only

Promethazine may be used to relieve allergy symptoms and nausea. Sedation is the main side effect and it may interact with several other drugs including antidepressants, antipsychotics, and other... View more

More about Hydroxyzine

More about Promethazine

Ratings & Reviews

Hydroxyzine has an average rating of 5.9 out of 10 from a total of 1408 ratings on Drugs.com. 47% of reviewers reported a positive effect, while 35% reported a negative effect.

Promethazine has an average rating of 7.2 out of 10 from a total of 392 ratings on Drugs.com. 65% of reviewers reported a positive effect, while 21% reported a negative effect.

View all 1408 reviews

View all 392 reviews

Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.

Drowsiness (21.9%)
Tiredness (10.5%)
Sleepy (6.3%)
Anxiety (5.6%)
Nausea (3.8%)
Dizziness (3.7%)
Dry mouth (3.1%)

View all Hydroxyzine side effects

Drowsiness (20.4%)
Nausea (14.3%)
Vomiting (6.6%)
Anxiety (5.6%)
Tiredness (5.6%)
Sleepy (5.4%)
Dizziness (4.8%)

View all Promethazine side effects

Drug Class

Generic Availability

Lower cost generic

Pricing and Coupons * Prices are without insurance

Quantity	4 tablet
Strength	hydrochloride 25 mg
Per unit^*	$2.74
Cost^*	$10.95

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Quantity	1 tablet
Strength	25 mg
Per unit^*	$10.14
Cost^*	$10.14

View all Promethazine prices

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Dosage Forms

Intramuscular solution
Oral capsule
Oral syrup
Oral tablet

Injectable solution
Oral syrup
Oral tablet
Rectal suppository

Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value.

7 hours

16 hours

CSA Schedule ¹ View glossary of CSA terms

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category

Category N Not classified

See the full pregnancy warnings document.

Category C Risk cannot be ruled out

See the full pregnancy warnings document.

Drug Interactions

A total of 581 drugs are known to interact with Hydroxyzine:

93 major drug interactions (368 brand and generic names)
484 moderate drug interactions (1992 brand and generic names)
4 minor drug interactions (16 brand and generic names)

A total of 689 drugs are known to interact with Promethazine:

94 major drug interactions (339 brand and generic names)
580 moderate drug interactions (2372 brand and generic names)
15 minor drug interactions (60 brand and generic names)

Alcohol/Food/Lifestyle Interactions

Alcohol can increase the nervous system side effects of hydrOXYzine such as dizziness, drowsiness... View more

Ask your doctor before using promethazine together with alcohol. This can cause uncontrollable... View more

Disease Interactions

First Approval Date

April 12, 1956

March 29, 1951

WADA Class View classifications

N/A

More Information

Patient Resources

Promethazine uses

Professional Resources

¹ The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Comparing Hydroxyzine vs Promethazine

See also:

Lexapro

Xanax

Xolair

Cymbalta

Paroxetine

Diazepam

Lorazepam

Venlafaxine

Buspirone

Alprazolam

Further information

Comparing Hydroxyzine vs Promethazine

See also:

Further information

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