Comparing Fluoxetine vs Trintellix

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
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Fluoxetine

Trintellix vortioxetine

Fluoxetine may be used for the treatment of depression and other mood disorders. It is more likely to cause insomnia than drowsiness. Prescribed for Anxiety and Stress, Major Depressive Disorder... View more

Trintellix may be used to treat depression in adults. It is different from other antidepressants currently on the market because it directly affects serotonin receptors as well as inhibiting... View more

Prescription only

Common side effects include: diarrhea, male sexual disorder, and nausea.

See the full Trintellix side effects document.

Pricing and Coupons

* Prices are without insurance

Quantity	100 each
Dosage	20 mg
Per Unit^*	$0.61
Cost^*	$60.68

View all fluoxetine prices

Quantity	30 tablet
Dosage	5 mg
Per Unit^*	$15.04
Cost^*	$451.10

View all Trintellix prices

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Generic Availability

Yes (this medicine)

Dosage Form(s) Available

Oral capsule
Oral delayed release capsule
Oral solution
Oral tablet

Oral tablet

Brand Names

Prozac

N/A

Half Life

The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value.

210 hours

66 hours

CSA Schedule**

View glossary of terms.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category

Category C Risk cannot be ruled out

See the full Pregnancy Warnings document.

Category C Risk cannot be ruled out

See the full Pregnancy Warnings document.

Drug Interactions

A total of 637 drugs are known to interact with fluoxetine:

148 major drug interactions (567 brand and generic names)
467 moderate drug interactions (1964 brand and generic names)
22 minor drug interactions (94 brand and generic names)

A total of 331 drugs are known to interact with Trintellix:

91 major drug interactions (425 brand and generic names)
239 moderate drug interactions (944 brand and generic names)
1 minor drug interactions (3 brand and generic names)

Alcohol/Food/Lifestyle Interactions

Alcohol can increase the nervous system side effects of FLUoxetine such as dizziness, drowsiness... View more

Alcohol can increase the nervous system side effects of vortioxetine such as dizziness, drowsiness... View more

Disease Interactions

First Approval Date

December 29, 1987

September 30, 2013

WADA Class

View World Anti-Doping Agency classifications.

N/A

More Information

Consumer Resources

Professional Resources

Prescribing Information

Related Treatment Guide

** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer