Comparing Duloxetine vs Milnacipran

For Depression: I recently reviewed this drug and gave it a 9/10 after 3 months. I thought that I had found what I had been looking for. Unfortunately, a month later my mood started to dip and the lethargy, that came with depression, never lifted. It still helped significantly more that the SSRIs that I’ve tried, but it isn’t quite right for me. That being said, it was very effective for my anxiety. Depression - not so much.

For Depression: Duloxitine was prescribed for me by my psychiatrist. I have suffered depression on and off for 25 year's. 6 year's ago after having my son switched from citalopram and thought it's pretty good. That was until I got used to the 30mg I was on and had to increase to 60mg, then 90mg and now I'm on 120mg. Sometimes I think I can't be without it then other time's I think not a chance that they working properly still. I was told they are a dual controlled medication which act as a mood lifter and motivator. If I'm honest I keep a diary of how I feel every day, and I have more bad days than good. I do have a lot going on in my life, which I think doesn't help. I've tried coming off a few time's but I hate the dizzy feeling from the side effect which leads to really bad feelings.

For Fibromyalgia: I have been on Savella for several years now and I am doing very well. The only bad thing is that it has elevated my blood pressure a bit. I normally take 1 pill twice daily, but when the weather changes ( especially in the mid- Fall), I sometimes do increase my dosage to 1 1/2 twice a day. And then when my fibro settles down and my pain isn't as bad, I go back to 1 pill twice daily. In the beginning, I did have a little bit of a hard time getting use to Savella, but I am glad I stuck with it. In the long-run, I am doing better with taking Savella. I do understand that not everyone can take Savella. Different meds react different ways to all different kinds of people.

For Fibromyalgia: Female, 24 here. I have persistent low mood for one year. Finally my doctor prescribed me milnacipran; common to treat depression here (I live in Japan). I've been using it for one month now, and it is fantastic. 1x25mg at dinner time only. I don't know whether it is placebo effect or not, but at the very least, it helps regulating my sleep. I can wake up in the morning again. I enjoy things again. It is now easier to avoid depression-inducing self-blaming thoughts. Side effect: hot flash on the first several days, and tolerable nausea. Some weight loss is observed, either from being able to get more exercise and less binging, or directly caused by milnacipran.