Comparing Duloxetine vs Milnacipran

For Depression: I am taking duloxetine, just had a horrific experience with the generic manufacture Solco. I have taken 4 different manufacture versions in 3 different dosages since June 2017. First day talking a Solco pill I had depressive episode, woke up next morning and had a panic attack. Crying, severe headache on right side, unconscious arm and leg twitching, inability to control my voice volume, loss of coordination. It was as if I suddenly reversed what remission I had achieved and broke through to a whole new ultra low. This went on 4 days before I suspected my meds. Went to ER because I thought I might be dying. Walgreens doesn't want to stock Tevas pills, and CVS has to special order them too, leaving me with a different manufacture and dosage combination again. I was really excited to feel good again, but I had to crawl back to start over a proprietary formula and delivery method that has no published science available to the public. I will report this to the FDA.

For Depression: Been taking generic cymbalta for about 2 months for depression, anxiety, and OCD. When I first started I fluctuated between super tired and super hyper, that lasted for a few weeks. I also got dizzy a lot. After about 4 weeks all the side effects went away and now it's helping a lot with depression and helps a bit with anxiety and OCD. Your mileage may vary but for me this medication has been a godsend.

For Fibromyalgia: I have been on Savella for several years now and I am doing very well. The only bad thing is that it has elevated my blood pressure a bit. I normally take 1 pill twice daily, but when the weather changes ( especially in the mid- Fall), I sometimes do increase my dosage to 1 1/2 twice a day. And then when my fibro settles down and my pain isn't as bad, I go back to 1 pill twice daily. In the beginning, I did have a little bit of a hard time getting use to Savella, but I am glad I stuck with it. In the long-run, I am doing better with taking Savella. I do understand that not everyone can take Savella. Different meds react different ways to all different kinds of people.

For Fibromyalgia: Female, 24 here. I have persistent low mood for one year. Finally my doctor prescribed me milnacipran; common to treat depression here (I live in Japan). I've been using it for one month now, and it is fantastic. 1x25mg at dinner time only. I don't know whether it is placebo effect or not, but at the very least, it helps regulating my sleep. I can wake up in the morning again. I enjoy things again. It is now easier to avoid depression-inducing self-blaming thoughts. Side effect: hot flash on the first several days, and tolerable nausea. Some weight loss is observed, either from being able to get more exercise and less binging, or directly caused by milnacipran.