Comparing Diphenhydramine vs Meclizine
Diphenhydramine | Meclizine |
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Diphenhydramine | Meclizine |
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Prescription and OTC
Diphenhydramine is an antihistamine that can be used to treat allergic reactions, relieve motion sickness, as a sleep aid, and relieve some symptoms of Parkinson's disease. Sedation is a common side... View more |
Prescription and OTC
Meclizine may be used to treat vertigo or nausea and vomiting associated with motion sickness; however, it takes approximately an hour to start working and may cause drowsiness, although it is less... View more |
Related suggestions Nausea/Vomiting
Motion Sickness
Meniere's Disease
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More about Diphenhydramine | More about Meclizine | ||||||||||||||||
Ratings & Reviews | |||||||||||||||||
Diphenhydramine has an average rating of 5.5 out of 10 from a total of 531 ratings on Drugs.com. 44% of reviewers reported a positive effect, while 41% reported a negative effect. |
Meclizine has an average rating of 7.4 out of 10 from a total of 225 ratings on Drugs.com. 68% of reviewers reported a positive effect, while 19% reported a negative effect. |
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Drug Class | |||||||||||||||||
Side Effects | |||||||||||||||||
See also: diphenhydramine side effects in more detail. |
See also: meclizine side effects in more detail. |
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Generic Availability | |||||||||||||||||
Lower cost generic |
Lower cost generic |
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Pricing and Coupons * Prices are without insurance | |||||||||||||||||
View all diphenhydramine prices |
View all meclizine prices |
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Dosage Form(s) Available | |||||||||||||||||
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Brand Names | |||||||||||||||||
Aler-Dryl, Aler-Tab, Aller-G-Time, Allergia-C, Allermax, Altaryl, Banaril, Banophen, Beldin, Belix, Ben-Tann, Benadryl, Benadryl Allergy, Benadryl Children's Allergy, Benahist-10, Benahist-50, Benoject-50, Buckley's Bedtime, Bydramine, Calm-Aid, Complete Allergy Relief, Compoz Nighttime Sleep Aid, ConRx Allergy, Dicopanol, Diphedryl, Diphen, Diphen AF, Diphen Cough, Diphenadryl, Diphendryl, Diphenhist, Diphenmax, Diphenydramine Quick Melt, Diphenyl, Diphenylin, Dormin, DPH, Dytan, Dytuss, Genahist, Help I Can't Sleep, Histaprin, Hydramine, Hydramine Compound, Hydramine Cough Syrup, Hyrexin, Miles Nervine, Nytol, Nytol Caplet, Nytol QuickCaps, Pharbedryl, Scot-Tussin Allergy, Siladryl Allergy, Silphen Cough, Simply Sleep, Sleep Tab II, Sleep-ettes D, Sleepinal, Sleepwell 2-nite, Snooze Fast, Sominex, Sominex Maximum Strength Caplet, Trux-adryl, Twilite, Unisom Liquid, Unisom SleepGels, Unisom SleepMelts, Unisom SleepMinis, Valu-Dryl, Vanamine PD, Vicks QlearQuil Nighttime Allergy Relief, Z-Sleep, ZzzQuil View more | Antivert, Antrizine, Bonine, D-Vert, Dramamine All Day Less Drowsy, Dramamine II, Dramamine Less Drowsy, Driminate II, Help I'm Nauseous, Motion-Time, Sea-Calm, Travel Sickness, Travel-Ease View more | ||||||||||||||||
Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. | |||||||||||||||||
9.3 hours |
6 hours |
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CSA Schedule ** View glossary of terms | |||||||||||||||||
Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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Pregnancy Category | |||||||||||||||||
Category B
No proven risk in humans
See the full pregnancy warnings document. |
Category B
No proven risk in humans
See the full pregnancy warnings document. |
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Drug Interactions | |||||||||||||||||
A total of 446 drugs are known to interact with diphenhydramine:
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A total of 280 drugs are known to interact with meclizine:
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Alcohol/Food/Lifestyle Interactions | |||||||||||||||||
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Disease Interactions | |||||||||||||||||
First Approval Date | |||||||||||||||||
March 04, 1946 |
February 14, 1957 |
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WADA Class View World Anti-Doping Agency classifications. | |||||||||||||||||
N/A |
N/A |
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More Information | |||||||||||||||||
Patient resources | |||||||||||||||||
Professional Resources | |||||||||||||||||
Related Treatment Guide | |||||||||||||||||
** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.