Comparing Bupropion vs Nefazodone

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Bupropion	Nefazodone	Enter another drug to compare

Bupropion

Nefazodone

Prescription only

Bupropion may be used in the treatment of depression or as an aid to smoking cessation; however, side effects may include insomnia, neuropsychiatric adverse events, or seizures. It carries a black... View more

Prescription only

Prescribed for Anxiety, Major Depressive Disorder, Panic Disorder, Depression. Nefazodone may also be used for purposes not listed in this medication guide.

More about Bupropion

More about Nefazodone

Ratings & Reviews

Bupropion has an average rating of 7.0 out of 10 from a total of 2913 ratings on Drugs.com. 60% of reviewers reported a positive effect, while 20% reported a negative effect.

Nefazodone has an average rating of 9.2 out of 10 from a total of 168 ratings on Drugs.com. 91% of reviewers reported a positive effect, while 7% reported a negative effect.

View all 2913 reviews

View all 168 reviews

Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.

Anxiety (16.4%)
Insomnia (11.7%)
Headaches (7.2%)
Sexual dysfunction (6.3%)
Irritability (6.2%)
Depression (5.6%)
Loss of appetite (5.6%)

View all Bupropion side effects

Anxiety (7.7%)
Sexual dysfunction (5.4%)
Liver damage (4.8%)
Weight gain (3.6%)
Withdrawal (3.6%)
Drowsiness (3.0%)
Panic attacks (2.4%)

View all Nefazodone side effects

Drug Class

Phenylpiperazine antidepressants

Generic Availability

Lower cost generic

Pricing and Coupons * Prices are without insurance

Quantity	30 each
Strength	150 mg/24 hours
Per unit^*	$0.48
Cost^*	$14.40

View all Bupropion prices

Quantity	60 tablet
Strength	100 mg
Per unit^*	$3.49
Cost^*	$209.37

View all Nefazodone prices

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Dosage Forms

Oral tablet
Oral tablet, extended release

Oral tablet

Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value.

30 hours

18 hours

CSA Schedule ¹ View glossary of CSA terms

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category

Category C Risk cannot be ruled out

See the full pregnancy warnings document.

Category C Risk cannot be ruled out

See the full pregnancy warnings document.

Drug Interactions

A total of 560 drugs are known to interact with Bupropion:

218 major drug interactions (953 brand and generic names)
337 moderate drug interactions (1877 brand and generic names)
5 minor drug interactions (16 brand and generic names)

A total of 782 drugs are known to interact with Nefazodone:

269 major drug interactions (901 brand and generic names)
486 moderate drug interactions (2105 brand and generic names)
27 minor drug interactions (71 brand and generic names)

Alcohol/Food/Lifestyle Interactions

Using buPROPion with alcohol may increase the risk of uncommon side effects such as seizures... View more

Alcohol can increase the nervous system side effects of nefazodone such as dizziness, drowsiness... View more

Disease Interactions

First Approval Date

December 30, 1985

December 22, 1994

WADA Class View classifications

N/A

More Information

Patient Resources

Bupropion uses

Professional Resources

¹ The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Comparing Bupropion vs Nefazodone

See also:

Vraylar

Auvelity

Rexulti

Lexapro

Zoloft

Seroquel

Prozac

Cymbalta

Wellbutrin

Duloxetine

Further information

Comparing Bupropion vs Nefazodone

See also:

Further information

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