Comparing Benadryl vs Hydrocortisone Topical
| Benadryl (diphenhydramine) | Hydrocortisone topical |
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| Benadryl (diphenhydramine) | Hydrocortisone topical |
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Prescription and OTC
Benadryl is used to treat allergies, motion sickness, and to relieve symptoms of Parkinson's Disease (PD) in patients unable to tolerate more potent agents. It may also be used off-label to help... View more |
Prescription and OTC
Prescribed for Hemorrhoids, Anal Itching, Pruritus, Dermatitis, Atopic Dermatitis, Proctitis, Eczema, Intertrigo, Skin Rash, Allergies, Aphthous Stomatitis - Recurrent, Gingivitis, Psoriasis... View more |
Related suggestions Allergies
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| More about Benadryl (diphenhydramine) | More about Hydrocortisone topical | ||||||||||||||||
| Ratings & Reviews | |||||||||||||||||
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Benadryl has an average rating of 7.0 out of 10 from a total of 80 ratings on Drugs.com. 60% of reviewers reported a positive effect, while 20% reported a negative effect. |
Hydrocortisone topical has an average rating of 7.0 out of 10 from a total of 65 ratings on Drugs.com. 58% of reviewers reported a positive effect, while 23% reported a negative effect. |
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| Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified. | |||||||||||||||||
View all Benadryl side effects |
View all Hydrocortisone topical side effects |
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| Drug Class | |||||||||||||||||
| Generic Availability | |||||||||||||||||
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N/A |
Lower cost generic |
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| Pricing and Coupons * Prices are without insurance | |||||||||||||||||
View all Benadryl prices |
View all Hydrocortisone topical prices |
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| Dosage Forms | |||||||||||||||||
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| Brand Names | |||||||||||||||||
| Other diphenhydramine brands include: Aler-Dryl, Aler-Tab, Aller-G-Time, Allergia-C, Allermax, Altaryl, Aurodryl Children's Allergy, Banaril, Banophen, Beldin, Belix, Ben-Tann, Benadryl Allergy, Benadryl Children's Allergy, Benahist-10, Benahist-50, Benoject-50, Buckley's Bedtime, Bydramine, Calm-Aid, Complete Allergy Relief, Compoz Nighttime Sleep Aid, ConRx Allergy, Dicopanol, Diphedryl, Diphen, Diphen AF, Diphen Cough, Diphenadryl, Diphendryl, Diphenhist, Diphenmax, Diphenydramine Quick Melt, Diphenyl, Diphenylin, Dormin, DPH, Dytan, Dytuss, Genahist, Help I Can't Sleep, Histaprin, Hydramine, Hydramine Compound, Hydramine Cough Syrup, Hyrexin, Miles Nervine, Nytol, Nytol Caplet, Nytol QuickCaps, Pharbedryl, Scot-Tussin Allergy, Siladryl Allergy, Silphen Cough, Simply Sleep, Sleep Tab II, Sleep Tablets, Sleep-ettes D, Sleepinal, Sleepwell 2-nite, Snooze Fast, Sominex, Sominex Maximum Strength Caplet, Trux-adryl, Twilite, Unisom Liquid, Unisom SleepGels, Unisom SleepMelts, Unisom SleepMinis, Valu-Dryl, Vanamine PD, Vicks QlearQuil Nighttime Allergy Relief, Z-Sleep, ZzzQuil View more | Ala-Cort, Ala-Scalp, Ala-Scalp HP, Anucort-HC, Anusol-HC, Anusol-HC Suppositories, Aquanil HC, Aquaphor Itch Relief, Aquax-H, Beta HC, Bioelements Immediate Comfort, Caldecort, Cortaid Intensive Therapy, Cortaid Maximum Strength, Cortaid with Aloe, Cortizone-10, Cortizone-10 Intensive Healing Formula, Cortizone-10 Plus, Cortizone-5, Dermarest Eczema Medicated, Dermarest Plus Anti-Itch, Dermtex HC, Gynecort Maximum Strength, Hemmorex-HC, Hemril-30, Hydroxate Gel, Hydroxym Cream, Hydroxym Gel, Itch-X Lotion, Locoid, Locoid Lipocream, Neosporin Eczema Essentials Anti-Itch Cream, NuCort, NuCort with Aloe, Pandel, Preparation H Anti-Itch Cream Hydrocortisone 1%, Procto-Med HC, Procto-Pak 1%, Proctocort, Proctozone HC, Recort Anti-Itch Cream, Sarnol-HC, Scalpicin, Texacort, U-Cort, Vagisil Anti-Itch Creme Sensitive Skin Formula View more | ||||||||||||||||
| Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value. | |||||||||||||||||
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9.3 hours |
N/A |
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| CSA Schedule 1 View glossary of CSA terms | |||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | |||||||||||||||||
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Category B
No proven risk in humans
See the full pregnancy warnings document. |
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
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| Drug Interactions | |||||||||||||||||
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A total of 449 drugs are known to interact with Benadryl:
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A total of 47 drugs are known to interact with Hydrocortisone topical:
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| Alcohol/Food/Lifestyle Interactions | |||||||||||||||||
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No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
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| Disease Interactions | |||||||||||||||||
| First Approval Date | |||||||||||||||||
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March 04, 1946 |
July 28, 1953 |
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| WADA Class View classifications | |||||||||||||||||
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N/A |
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| More Information | |||||||||||||||||
| Patient Resources | |||||||||||||||||
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| Related Treatment Guide | |||||||||||||||||
1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
See also:
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.