Comparing Baclofen vs Tizanidine

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
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Baclofen

Tizanidine

Baclofen relieves muscle spasm associated with multiple sclerosis and spinal cord injury or disease, but its use is limited by its ability to cause sedation and increase seizure risk. Prescribed for... View more

Tizanidine relieves muscle spasms but may cause sleepiness, a drop in blood pressure, and sedation. The dosage should be individualized and because it only lasts for a short time in the body, can be... View more

Prescription only

Ratings & Reviews

View all 374 reviews

View all 309 reviews

Drug Class

Skeletal muscle relaxants

Skeletal muscle relaxants

Side Effects

Commonly reported side effects include: drowsiness.

See the full baclofen side effects document.

Commonly reported side effects include: bradycardia, dizziness, drowsiness, hypotension, asthenia, fatigue, and xerostomia.

See the full tizanidine side effects document.

Pricing and Coupons

* Prices are without insurance

Quantity	50 each
Dosage	10 mg
Per Unit^*	$0.63
Cost^*	$31.28

View all baclofen prices

Quantity	50 each
Dosage	4 mg
Per Unit^*	$0.63
Cost^*	$31.48

View all tizanidine prices

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Generic Availability

Yes (this medicine)

Dosage Form(s) Available

Intrathecal solution
Oral tablet

Oral capsule
Oral tablet

Brand Names

Gablofen, Lioresal, Lioresal Intrathecal, Ozobax Zanaflex

Half Life

The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value.

6.8 hours

2.5 hours

CSA Schedule**

View glossary of terms.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category

Category C Risk cannot be ruled out

See the full Pregnancy Warnings document.

Category C Risk cannot be ruled out

See the full Pregnancy Warnings document.

Drug Interactions

A total of 348 drugs are known to interact with baclofen:

25 major drug interactions (140 brand and generic names)
322 moderate drug interactions (1272 brand and generic names)
1 minor drug interactions (2 brand and generic names)

A total of 580 drugs are known to interact with tizanidine:

228 major drug interactions (814 brand and generic names)
350 moderate drug interactions (1401 brand and generic names)
2 minor drug interactions (11 brand and generic names)

Alcohol/Food/Lifestyle Interactions

Alcohol can increase the nervous system side effects of baclofen such as dizziness, drowsiness, and... View more

Using tiZANidine together with alcohol may increase side effects such as dizziness, drowsiness... View more

Disease Interactions

First Approval Date

November 22, 1977

November 27, 1996

WADA Class

View World Anti-Doping Agency classifications.

N/A

More Information

Consumer Resources

Advanced Reading

Professional Resources

Related Treatment Guide

** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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