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Xtampza ER User Reviews & Ratings (Page 2)

Xtampza ER has an average rating of 3.9 out of 10 from a total of 169 reviews on Drugs.com. 24% of reviewers reported a positive experience, while 62% reported a negative experience.

Reviews for Xtampza ER

Commonly mentioned side effects
  • Evi...
  • December 20, 2020

For Chronic Pain "I was born with curvature of the spine, then my job as a nurse's aide for about 20 years kind of finished my back off. I've been using pain meds, with varying degrees of success, for about 40 years. About a year ago, the pain clinic decided to put me on Xtampza ER. They know I cannot sleep after taking pain meds as they give me energy so I take both in the morning. I get no pain relief, but what surprised me was also no energy. I can sleep even after taking 2 Xtampza ER, but cannot sleep after 1/2 hydrocodone 5/325. I can take 3 days off of Xtampza ER and feel no difference. 1/2 of a hydrocodone 5/325 gives me better pain relief. Something is not right here. Please, please fix this."

1 / 10
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  • Nyt...
  • Taken for 1 to 6 months
  • July 4, 2019

For Chronic Pain "This drug made my nightmare even worse. In the 5 months I was on it, it caused me to gain nearly 60 pounds! Over 10 pounds a month! I had to literally buy bigger clothes every 2 weeks. Thank goodness for thrift stores! As for the pain relief, it didn't do as well as the Opana that I was on prior to the Xtampza. Then Opana was pulled from the market suddenly, though, supposedly in the reaction to the 'opioid crisis,' so I needed something to replace it, and the doctors gave me Xtampza that fall. I suffered with worse pain relief and rapid weight gain for 5 months, until they finally switched me to something else! I would not suggest this medicine to my worse enemy! You may not suffer from the extreme weight gain like I did. You may get better pain relief than I did. But beware, because some of us have *awful* side effects from this stuff!"

1 / 10
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  • TKa...
  • Taken for 2 to 5 years
  • April 6, 2019

For Pain "After nearly a year of using 18mg Xtampza (started at 9mg and worked up to 18mg), I’ve found waking an hour early and taking it with high-fat yogurt and sleeping another hour leaves me feeling refreshed and on my way. It only seems to work for 6-8 hours so I use 20mg baclofen and 10mg oxy for breakthrough between doses. It also helps to use Tylenol in addition as it synergizes both forms. Also, if you can get your BP up for at least 20 minutes by taking a fast-paced walk it also helps get the meds into your system much quicker. It’s not always easy but exercise helps in every way if you’re able. It’s not the perfect medicine but without it I would be miserable and likely unable to work and tolerate the cancers and radiation proctitis nearly as well as I am."

9 / 10
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Frequently asked questions

  • Sle...
  • Taken for 1 to 6 months
  • February 7, 2019

For Chronic Pain "In a word...awful. I've been on 2x18mg Xtampza ER for over a month now, after my sadistic insurance co refused to cover OxyContin, which I've been taking 2x20mg since 07 for severe pelvic floor pain. While Xtampza is designed to avert abuse, it most definitely is not designed for any credible chronic pain relief. First and foremost, it's doing very little for my pain. It takes FOREVER, like 2+ hours(!), to work, and lasts 3-4 hours, at best. I'm being generous saying it 'works', since it barely takes the edge off my pain. I still have to take breakthrough meds, even while this junk is supposed to be in full effect. I regularly experience strong side effects described by other reviews, including headaches, nausea, sleeplessness, and high anxiety. It's amusing to hear the claims of this med being 'exactly the same' as OxyContin - the one thing that actually worked."

1 / 10
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  • Pet...
  • Taken for 1 to 6 months
  • April 2, 2018

For Chronic Pain "Dangerous erratic medication. Package says to take with the same amount and same type of food every dose. How can you do that? I can tell you this for sure. Sometimes it works, sometimes you OD, sometimes it does nothing for the pain. You never know what you will get. This medication is going to OVERDOSE PEOPLE! You can tell the good reviews on here were written by the drug maker. The only truthful ones sound like this."

1 / 10
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  • Anonymous
  • February 7, 2020

For Chronic Pain "I was forced off OxyContin by my insurance plan and placed on Xtampza, and it definitely does not work for my pain as well as OxyContin. I was told they are supposed to be the same medication except for one is a tablet and one is a capsule, but they are not as far as I (my body) am concerned. Also, because this drug is so expensive, the pharmacy does not even carry it. I am supposed to call a week or so in advance to make sure they can try to get it shipped in, so now I'm facing possible issues of not being able to get my meds when they are due to be filled. This is causing all types of issues and hoops for me to jump through just to get my prescriptions."

3 / 10
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  • Spa...
  • May 8, 2019

For Chronic Pain "Until last weekend, I had three nights of good sleep. It takes 4 hours (zombie time) to come on. It then helps with pain for 5.5 hours. It is formulated using fatty acids from wax. It does not mix with water, you must eat some fat for it to work, which sucks at bedtime. If I take it just before falling asleep, I wake up to pee and then I lay awake for 3-4 hours. If I take it 4 hours before bedtime, then I have 4 hours to go to sleep. I have found a way to take it and get a good night's sleep! I get up at 5:00 AM, eat a Siggi's Triple Cream yogurt and a few tablespoons of heavy cream in a glass, take the dose, then back to sleep. I wake up at 8:30-9:00, and it's working. Second dose between 2:00-3:00 PM. FWIW (for what it's worth), coconut oil has 14g of fat per tablespoon. I talked to my pharmacist, and they take the coupon for generic OxyContin, and 60 will cost me about $110 a month."

8 / 10
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More FAQ

  • Rel...
  • Taken for 6 months to 1 year
  • August 29, 2018

For Pain "Xtampza gave me my dignity back. I was bedridden for over four years straight, and after literally trying every pain medication in existence (including Fentanyl, a spinal nerve stimulator, and a pain pump), I am now able to function at a much higher level. This medication is ideal for those who metabolize medications rapidly, which can be discovered by taking a P-450 blood test. Because of the abuse deterrent capsule, the beads of medication break down slowly. In my experience, this keeps side effects like nausea down. It lasts longer than any ER medication I have tried and is more stable in its release. I am losing weight gained previously. The capsule can be sprinkled on applesauce, but it needs to have a fat source to break down properly. A cracker or cookie easily solves this, which is a good practice to have in place with any medication to protect the stomach lining. I am prescribed a breakthrough medication besides Xtampza. I am thankful beyond words that this has worked for me."

10 / 10
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  • SoB...
  • Taken for 6 months to 1 year
  • June 12, 2023

For Chronic Pain "I’ve been on high-level opioids for 23 years due to a debilitating and disabling accident. For 18 years: six 80 mg OC with six 30 mg Roxicodone for breakthrough pain. Then, it was six 60 mg MS Contin (morphine) with the six 30s. Then, the opioid crisis. From 540 mg daily down to 90 in a year!!! The docs and insurance companies are the criminals here. If 90 mg is “appropriate,” then why was I on 540 mg/day? And 660 mg of OxyContin and oxycodone before that?? So, now we have Xtampza. Completely worthless. That’s all I can say. It does nothing for pain. All of the poor souls like myself who have always followed the rules with narcotics contracts and pee tests are the ones who got completely screwed! Now, try getting a pain doctor to titrate! I’ve been on the same dose for 3 years; completely tolerant to it. God bless you all who continue to suffer."

2 / 10
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  • Sea...
  • Taken for less than 1 month
  • September 4, 2019

For Chronic Pain "At my request, due to daily soaking sweats, I went from 8 years of methadone for chronic spinal pain (add severe psoriatic AR + RA) to Xtampza 13.5 twice per day. The pharmaceutical company has played a joke on us with this one. They need to just trash the Xtampza and start all over. I never knew just how well the methadone was working (despite sweats) to lessen my pain until I switched to this garbage."

1 / 10
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  • Mos...
  • Taken for less than 1 month
  • February 8, 2020

For Chronic Pain "So, my doctor thinks Xtampza ER is the safest choice? Even though plasma levels are hugely dependent on high-fat food. I think this drug is dangerous. Give me plain old, cheap, generic oxycodone any day. Every day since being switched to Xtampza has been agonizing."

1 / 10
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  • Che...
  • September 13, 2019

For Chronic Pain "I too was forced to use something other than MS Contin. Xtampza was chosen, and I suffered through it for 3 weeks before calling my physician in tears to let him know that I had no relief whatsoever from the pain, and as well, I was experiencing headaches, diarrhea, and deeper depression. I was then given a prescription for Belbuca film. Would have liked to try it, but insurance doesn't cover it, and it costs $475 a month! What are we to do???"

1 / 10
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  • Chi...
  • Taken for 2 to 5 years
  • March 2, 2025

For Chronic Pain "I have been taking Xtampza for a couple of years now along with my 15 mg oxycodone, and I would be in big trouble if I didn’t have the Xtampza. This medication has helped me a lot. I can sleep the whole night through with this medication."

10 / 10
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  • Blo...
  • Taken for 1 to 2 years
  • April 12, 2020

For Chronic Pain "I’ve been on Xtampza since January 2019. I have post-laminectomy syndrome, spinal stenosis, levoscoliosis, rheumatoid arthritis, facet joint arthrosis, DDD, and a few herniated discs in my C-spine and L-spine, and I’m only 35. As with all medications, everyone’s body works differently in regards to medicine. For me, Xtampza works great, and I find that it covers my pain most of the time for a full 24 hours. Granted, my pain does change with the weather. However, I have found that Xtampza works better than OxyContin for me."

10 / 10
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  • Der...
  • Taken for 1 to 6 months
  • January 2, 2020

For Chronic Pain "I was on Fentanyl 50 mcg per hr, changing the patch every 48 hrs, before asking to be switched to MS Contin 60 mgs TID, and that stopped working after over 3 years of being on the same dosage. Finally, my doctor suggested I switch to Xtampza ER 36 mg BID. Once I switched to Xtampza ER, my pain not only increased, but my breakthrough medications had to be increased to Roxicodone 30 mg every 4-6 hrs PRN. Finally, after 3 months on Xtampza, my doctor put me back on Exalgo 16 mg/24 hr and left me on the Roxicodone 30 mg every 4-6 hrs PRN, but I hardly have to use more than 3 of those per day and am no longer suffering any pain."

1 / 10
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  • Ski...
  • July 13, 2018

For Chronic Pain "I have taken all the usual prescription opiates over the past 14 years almost daily. Xtampza is very inconsistent and dangerous and therefore ineffective. My experience is that it is not time-released. The withdrawal is the worst, yet I paid a lot of money for these fancy capsules, which are just a marketing scheme. I would not recommend this so-called pain med to anyone. Big pharma guinea pig!!"

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  • Pat...
  • Taken for 1 to 2 years
  • June 17, 2023

For Chronic Pain "I have been taking this medication for over a year, hoping it would help, but finally gave up. It just makes me tired and sometimes upsets my stomach. It’s so insulting, the way we chronic pain patients are treated in the USA. I’m wondering if this is a political thing and if people are treated with more dignity and compassion elsewhere. It’s very isolating to have a progressive illness for which there is no cure, and having to fight with varying success for proper relief just makes it worse. Believe me, I used to be super optimistic and never thought my life would come to this. I still have short-acting oxycodone, which does help, but it’s not enough. There is nothing for extended relief and no recourse when an emergency situation arises that causes me to need more help than usual, e.g., my husband was in the ICU with respiratory failure, and I had to be there for him, causing more nerve damage, etc. But no extra medication, so I ran out a few days early that month and oh well, too bad."

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  • Roc...
  • Taken for 6 months to 1 year
  • June 21, 2020

For Chronic Pain "I was started on Xtampza ER in Jan 2020. CMS removed OxyContin ER from the formulary in 2020 and switched to Xtampza ER mfg by Collegium. My pain group started me on 18 mg Xtampza vs. the 20 mg OxyContin ER. After three months, I told PM it was not working. She upped it to 27 mg Xtampza. I hit the coverage gap in May. I refuse to pay over $100+ for a drug that does very little, so when I had my telehealth appt on Friday, I told her it really was doing little to help me, and I refused to have it filled. It's just shy of being a worthless pain medication. I have heard from several the same thing."

2 / 10
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  • Mia...
  • Taken for less than 1 month
  • September 8, 2018

For Chronic Pain "I was put on this medication for chronic back pain and primary progressive MS. I had been on OxyContin and oxycodone. The medication simply doesn’t work for me. My insurance company finally approved my old medications for me. I understand the abuse that goes along with the opiate medications. However, I don’t abuse it. I never will, either. I hate taking pain medications, but I have no choice. Good luck with the pain for all of you."

2 / 10
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  • Ano...
  • Taken for less than 1 month
  • November 17, 2021

For Chronic Pain "I was just forced to this Xtampza after having been on OxyContin ER 40 mg x 3 a day for over 10 years. I never had any issues with Purdue Pharmaceuticals OxyContin. This Xtampza is a joke. Dr. is force tapering & switched me to 36 mg Xtampza ER 2 x a day. My dose was lowered by 40 mg a day in one go. I'm experiencing horrific withdrawals, and this medication is NOT working at all. Twice a day is not enough. The bioavailability is all over the board and way too inconsistent, depending on high-fat food. This medication should be pulled off the market. Does NOT last anywhere near a 12-hour period. The 'studies' showing it does are a damn LIE. It's all about the addicts now. Guess what? Those addicts will keep using & move on. However, chronic pain patients are being force tapered, thrown to the streets, and left to fend for themselves. Many are paying for this with their lives. Something needs to change here. We need to get louder or nothing will change this suffering."

2 / 10
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  • Mar...
  • Taken for 1 to 6 months
  • October 18, 2018

For Chronic Pain "Moved and had to change doctor. Was given Xtampza twice daily. I have found this medication horrible. It does not work on a consistent level, any relief that it gives quickly fades. Twelve-hour relief is a joke, maybe six to seven hours. Blood pressure has gone up, needed to increase my atenolol 25 mg. Nausea soon becomes a constant companion, with headaches to add to the original chronic pain. This has been my experience, I also see many others have issues with this medication."

1 / 10
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  • Med...
  • Taken for less than 1 month
  • April 17, 2023

For Chronic Pain "I was recently put on this medication Xtampza ER and am not very happy. I have been on Percocet 10 mg 4 a day for about 10 years. It wasn’t helpful much anymore. My new primary care doctor decided to do a time-release medication. I had read so many bad reviews about this medicine I wasn’t sure if I should try it. I had to get insurance to approve a PA to get it because it cost $600.00. This medication doesn’t touch my pain. I hate it. It’s like taking baby aspirin."

1 / 10
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  • Spa...
  • Taken for less than 1 month
  • February 13, 2019

For Chronic Pain "I was just switched to Xtampza ER, took my first dose this morning. My doctor did not mention food at all, but I always read about the meds I take. In BOLD, they say to take this med with food. If you take it in the morning before eating, you will get maybe half the dose. The oral bioavailability goes up by as much as 150% with a high-fat/high-calorie meal. I called the manufacturer, but they were unable to tell me exactly what is a “high-fat/high-calorie meal.” I ate some walnuts, two slices of Ezekiel bread toasted with butter, and about a cup of Promised Land chocolate milk. They also say that you should eat the same amount of food with each dose to maintain even blood serum levels. My guess is it is this lack of knowledge that is causing some patients to find this drug ineffective or erratic. I’ll probably settle on 1/4 cup walnuts, a couple of eggs (boiled), and maybe a Boost Plus (or chocolate milk). In any case, it seems to be working."

8 / 10
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  • Ret...
  • Taken for less than 1 month
  • February 8, 2020

For Chronic Pain "Started this medicine three weeks ago, and it doesn’t help much at all for pain. Don’t do well with capsules, so open it up and put contents on yogurt to consume. For breakthrough pain, dropped from 30 mg oxycodone to a smaller quantity of 15 mg, and that hasn’t worked either. Now, constant pain level worse than ever. Worse, three of the capsules were empty."

2 / 10
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  • Deb...
  • Taken for 1 to 6 months
  • May 26, 2018

For Chronic Pain "Our county is one of several that is suing the drug manufacturers, so in order to look good, the doctors at my pain clinic have totally messed me up. I was on 2 Oxycontin 30 mg ER, plus my breakthrough pain medication. They have replaced the Oxycontin with the Xtampza ER 27 mg. I am in so much pain that I often can't get out of bed. My blood pressure has gone up since taking this, so they have upped my BP medication."

1 / 10
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