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Xtampza ER and Depression: What Users Say

Depression: mentioned by 5 users (3.0%)

Based on user experiences from 169 Xtampza ER reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

nausea 11.8%
headaches 7.7%
dizziness 4.7%
nightmares 4.7%
pain 4.7%
weight gain 4.1%
withdrawal 4.1%
anxiety 3.6%
diarrhea 3.6%
depression 3.0%

Reviews for Xtampza ER

Commonly mentioned side effects
  • Bud...
  • Taken for less than 1 month
  • February 3, 2020

For Chronic Pain "I was on OxyContin for 15 plus years, and I went to fill my prescription, but the insurance company cut me off. After a week of awfulness, I got my new medication Xtampza. I've only been on it for 4 days, and it's been the worst. I was fine on OxyContin except for constipation, and I had that figured out. I take my Xtampza and about 30 minutes later, I feel like I am at the end of my life. I'm so depressed and crying. Then, about 1 to 2 hours later, the depression is gone. I hope this is not going to continue, or else I need something else for pain. I feel like I have the flu and other issues. I'm not sure if it's the Xtampza or results from stopping the OxyContin. I don't understand why the honest, sick old people get screwed because these drug addicts are abusing drugs. This opioid war is hurting good people that need pain relief. The addicts will just find another way to abuse the system."

5 / 10
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420 Report
  • Hop...
  • Taken for 6 months to 1 year
  • April 1, 2021

For Chronic Pain "Due to a forehead injury, I have chronic nerve pain. But my excruciating pain was well-controlled when I was taking OxyContin 20 mg AM & PM, with 4 Tramadol and 4 Percocet 10 mg a day as needed for breakthrough. But that all changed when insurance would no longer cover OxyContin and the pandemic hit, and there is a shortage of generic OxyContin 20 mg. Now I take Xtampza ER 18 mg. I take it with a high-fat food as suggested, and this medication is useless. I'm so depressed and not sure how much longer I can go on. My doctor mentioned putting me on Dilaudid ER and Dilaudid 10 mg 4 times daily, but Dilaudid is stronger and I would rather not have to take something stronger when the alternative lesser medication used to work fine! But I can't go on like this much longer! For those that Xtampza is effective for, I'm very happy for you, but for those of us that it is no help, or in my case, I think it makes the pain worse, it's devastating! God bless you all!"

1 / 10
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169 Report
  • Che...
  • September 13, 2019

For Chronic Pain "I too was forced to use something other than MS Contin. Xtampza was chosen, and I suffered through it for 3 weeks before calling my physician in tears to let him know that I had no relief whatsoever from the pain, and as well, I was experiencing headaches, diarrhea, and deeper depression. I was then given a prescription for Belbuca film. Would have liked to try it, but insurance doesn't cover it, and it costs $475 a month! What are we to do???"

1 / 10
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61 Report

Frequently asked questions

  • Pat...
  • Taken for less than 1 month
  • February 15, 2020

For Pain "This medicine does absolutely nothing for pain. I tried taking it with fatty foods, it didn’t work. Depression set in, so I stopped taking this $600 month drug."

1 / 10
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43 Report
  • Anonymous
  • Taken for 1 to 6 months
  • September 8, 2020

For Chronic Pain "I don't know what the actual active ingredient is in this? Causes depression and does nothing for pain."

1 / 10
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23 Report

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Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.