Skip to main content

Is Xtampza ER a controlled substance?

Medically reviewed by Judith Stewart, BPharm. Last updated on Feb 13, 2024.

Official answer

by Drugs.com

Yes. Xtampza ER (oxycodone) is a schedule II controlled substance.

What is Xtampza ER?

Xtampza ER (oxycodone) an opioid agonist indicated for the management of pain severe enough to require daily, around-the-clock, long-term opioid treatment and for which alternative treatment options are inadequate.

Xtampza ER is an extended-release, abuse-deterrent formulation of oxycodone for twice-daily administration.

What is a Schedule II Controlled Substance?

Drugs placed in Schedule II of the Controlled Substances Act (CSA) have a high potential for abuse and dependence.

Drugs in Schedule II have a currently accepted medical use in the United States or a currently accepted medical use with severe restrictions. Abuse of these drugs may lead to severe psychological or physical dependence.

Examples of Schedule II substances include morphine, cocaine, hydrocodone, oxycodone, fentanyl, and methylphenidate.

What does Abuse-Deterrent mean?

Xtampza ER uses the proprietary DETERx® technology platform to prevent abuse of the active ingredient oxycodone. It is designed to prevent abuse by maintaining the drug release profile even after physical manipulation including chewing and crushing/dissolving. Misuse of Xtampza ER can lead to overdose and death.

Read next

How long does oxycodone stay in your system?

Immediate-release oxycodone has a half-life of just under 4 hours which means the pain-relieving effects of one dose will be gone within 6 to 24 hours, but it can remain detectable in saliva, urine, and hair for much longer. In saliva, oxycodone is detectable within minutes of taking it and lasts for up to 48 hours (2 days). Oxycodone is detectable in urine within 1 to 3 hours and will stay detectable for 1 to 4 days. Like most other opioids, oxycodone is detectable in hair for up to 90 days. Continue reading

Which drugs cause opioid-induced constipation?

Any drug that is classified as an "opioid" can cause constipation. Examples of commonly prescribed opioids that may cause this side effect include morphine, tramadol, fentanyl, methadone, hydrocodone, codeine and oxycodone. Continue reading

Oxycodone vs OxyContin - What's the difference?

Oxycodone (also known as Oxy IR) and Oxycontin both contain oxycodone, but the main difference is that Oxycontin is the brand name of a long-acting form of oxycodone. Oxycontin releases oxycodone slowly and continuously over 12 hours and only needs to be given twice a day. Oxycodone is shorter-acting, with an average half-life of 3.2 hours, which means that half the dose of oxycodone is eliminated in 3.2 hours, which is why it is usually given four to six times a day to provide all-day pain relief. Oxycodone is usually given for acute pain, such as that following surgery or trauma, whereas Oxycontin may be given for chronic or long-term pain, such as that caused by cancer. Oxycontin should only be considered in those with chronic severe pain that have already found a trial of oxycodone to be beneficial. Continue reading

Related medical questions

Drug information

Related support groups