Lupron Depot for Prostate Cancer User Reviews (Page 2)

• Rob...
• Taken for 1 to 2 years
• November 20, 2024

"Prostate normal at last checkup. Dosing sequence: 1 month, 3 months, 6 months x 3. Experiencing joint pain in shoulders, hips, knees, and periodic sharp pains in the head and neck area. Random stabbing pains in the left thigh and feet as if being jabbed with a large needle. Moderate to severe swelling in the feet and lower legs. Frequent hot flashes. Frequent intestinal issues. Frequent need to urinate. Extreme fatigue. Irritability."

• Mik...
• Taken for 1 to 2 years
• January 13, 2025

"Overwhelming, suffocating hot flashes that cause instant full-body sweating. This has caused disruption to all aspects of each day (whether at work, at leisure time, or bedtime). This drug causes weight gain regardless of exercise intensity. It has completely stopped all sex drive or interest. It has caused genital shrinkage and, at times, discomfort. I have unusual fatigue and muscle atrophy. I have been getting the drug for a year and a half. I will not be able to tolerate any more of this drug. It has kept my testosterone level at near undetectable levels."

• Ric...
• Taken for 1 to 6 months
• November 8, 2024

"Some hot flashes for short periods when thinking hard and only for maybe 2 or 3 minutes. Zero sex drive. Maybe joint pain. Maybe less energy. PSA at 0.25 after 3 or 4 months. There is some merit in not wanting to have sex often for that has been cured."

• Sco...
• Taken for 6 months to 1 year
• May 17, 2023

"Diagnosed with prostate cancer with a Gleason 7, PSA 8.2. Received a 6-month Lupron shot on Nov 15, 2022, and 20 sessions of radiation starting Jan. 18, 2023. I have suffered hot flashes several times a day and night, and they have become more intense in the last 6 weeks, by that, I mean I get completely soaked several times a day and night. I have gained around 20 pounds, have a loss of muscle strength, neuropathy in my hands, bone pains in my feet, back pain, mood swings, and lack of motivation to get moving. I do ride my bicycle several times a week, about 100-plus miles, and this is how I keep my sanity. Last appointment with the doctor was on May 15."

• Bru...
• Taken for 1 to 6 months
• December 26, 2024

"I am taking this drug along with 10 mg of Prednisone, so some of my symptoms may be from either drug. I've been taking Lupron Depot for four months and the prednisone for eight months. Hot flashes, 15-20 per day. Lasting 3-4 minutes. Dizziness, but much better since I stopped taking Flomax. Weight gain, always hungry. Prednisone does this to me. Fainting, may be dehydrated at times. A bit of chest pain, but not serious."

• Ger...
• Taken for 5 to 10 years
• May 22, 2025

"Lupron Depot 22.5. This is the second time in 9 years I have taken this shot. A recent finding of lymph node cancer was noted, so 5 radiation sessions were to be administered. Two times while on the table to begin this radiation, the radiologist could not locate cancer that was present on a PET scan. It seems the Lupron masked the cancer. That is where I am now. Both times on Lupron I had night and day sweats, muscle aches, and a general feeling of weakness. I had a prostatectomy in 2016. I also had renal cancer in both kidneys. One was cryoablated (right) and the other was by partial nephrectomy (1/25). The uro said the renal cancers did not come via prostate."

• Tim...
• Taken for 6 months to 1 year
• February 9, 2025

"1 year on Lupron 3-month shots after I had prostate removed with 1 spot of cancer spreading to hip 5 months after removal. 3 hits of radiation cleared spot. PSA undetectable for 1 year now with hot flashes only side effect, but now knee and ankle ligament sensitivity like hitting the funny bone... little numbness starting in the same areas. I'm considering a vacation until a PSA rise? Risky but don't want more damage in legs and hope it will reverse some? Been taking fenbendazole, Joe Tippins Protocol, over the same year. Good luck to all during your life's journey and see ya on the other side ✨️"

• jam...
• Taken for 1 to 6 months
• January 19, 2025

"Weakness, itching skin, high blood pressure, increased A1C and glucose levels, diminished platelet level and red blood cells. It has reduced my PSA from 7.8 to 1.6. Have taken additional drugs to reduce blood pressure, another to help with urinary incontinence, and antihistamine for itching skin."

• Ano...
• Taken for 1 to 2 years
• May 19, 2025

"I've been taking it for over a year and noticed a pronounced sadness and depression that wasn't there before. I am an adult male. I also have weight gain even though I exercise. I have to force myself to do things. My PSA and testosterone have come down to almost zero."

• Ano...
• Taken for 5 to 10 years
• May 24, 2025

"I have been treated with Lupron Depot for seven years now for my prostate cancer, along with radiation, Taxotere infusions, and apalutamide. After reading the list of side effects, I now understand that my problems with memory loss, irritability, lack of energy, and trouble sleeping were due to this medication. My cancer remains but is not progressing, and my oncologist is happy with my progress and blood work."

• Chu...
• Taken for 6 months to 1 year
• May 19, 2023

"76YO. Got Bicalutamide pills and a Lupron shot twice before my 'High Intensity Focused Ultrasound (HIFU)' operation to kill my prostate in 2019. Fatigue was my worst side effect. Did serious and intense Max Gerson Cancer Protocol therapy for three years. Totally off alcohol and mostly vegetarian. Mostly no carbs. Lost twenty pounds. When PSA started creeping up, my urologist put me on strictly Bicalutamide pills once a day (50mg). Negligible PSA for almost two years until tender breast and some enlargement took me off it. Been off for six months and back to normal in every way, including testosterone. PSA is creeping up again, and I think I will go back to the pills but only once or twice a week and see how my PSA does. I get the PSA checked every other month. I feel very good."

• KME...
• Taken for less than 1 month
• February 11, 2025

"I got this injection about a month ago. In the last week I have had several of the side effects such as gastro issues involving constipation and diarrhea. I also occasionally feel bloated. Also, hot and cold chills. My number one complaint is the pain in my left thigh bone. I haven't slept well with this pain and discomfort. Just in that one area on my thigh. I have not gotten any other side effects."

• Swo...
• Taken for 1 to 6 months
• June 10, 2025

"Well, for the men's side of this deal, this is a tricky drug to compile complaints on, because its intended purpose does show efficacy in working, but it has major other side effects that some can be permanent, as well as a lot of extra risks and long-term quality of life issues due to the terrible side effect risks this drug has. It helps one thing but causes a lot of other issues, so overall health, quality of life, and the risk of cancer need super careful consideration before doing this drug at all. It's not a joke drug like 'take 2 aspirin and call me in the morning' kind of thing. The other effect this drug has is not a curative effect, it's just a 'hey, slow down, don't spread so fast' type of deal. It's an added line of defense drug, not a curative type. For high-risk persons, it may be of value for them to do, lower-risk types should avoid it. Have to decide if the trade-offs of worse quality of life over staying alive longer are worth it, that's based on cancer grade and risks."

• Gio...
• Taken for 1 to 6 months
• March 22, 2025

"I have had a prostatectomy followed by biochemical recurrence, and my physician recommended one year of Lupron Depot and 45 sessions of external beam radiation, provided simultaneously. I selected the 3-month injection due to reports of possibly fewer side effects. I am nearly finished with my first 3-month Lupron injection and only have 15 more radiation sessions. Side effects from Lupron have been extremely minimal. I had no injection site reaction or pain. I experienced body heat at times, especially when sleeping, but it has been minimal. I just have to remove my sweatshirt or uncover in bed. I do keep my bedroom cooler, and this helps. I have been dizzy but had dizziness before the Lupron or external beam radiation upon getting up from a seated position. Walking required me to slow down due to mild dizziness. I work out daily with free weights, 100 crunches, and 20-30 minutes on a stationary bike, and I firmly believe that this has helped. I had fatigue with exercise for the first week."

• Flo...
• July 22, 2014

"Hot flashes and chills. Stomach became larger and weight gain. Hot flashes are very annoying. Fainted, and the doctor said it probably was due to dehydration."

• Lup...
• July 21, 2019

"Brain fog, hot flashes, bone chills, and memory loss. Drug is poison."

• Anonymous
• May 25, 2016

"My dad had 1 shot of Lupron at age 80 for elevated prostate cancer. He lost control of his muscles, was unable to walk, and accelerated his dementia. My dad passed away 10 months after the shot."

• rus...
• Taken for less than 1 month
• March 27, 2025

"It has been 2+ weeks after my injection. My level of energy has dropped dramatically, and there seems to be more ringing in my ears."

• RDB...
• Taken for 1 to 6 months
• September 19, 2024

"Hot flashes, sweating, bathroom multiple times a night, and daytime. Mood swings. Some headaches. Tiredness. Sometimes my patience wears a bit thin."

• Ral...
• Taken for 6 months to 1 year
• December 4, 2024

"Hot flashes, fatigue, headache, blurry vision, and dizziness. When I get the hot flashes, it lasts for two to three minutes. I can deal with the side effects because they're not severe."

• win...
• Taken for 2 to 5 years
• January 4, 2025

"Lupron injections by doctor for several months. Seems to be doing its job. I do have hot flashes, which I have been treating with megestrol. Medicines used in treating prostate cancer."