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Prempro User Reviews & Ratings (Page 3)

Prempro has an average rating of 6.9 out of 10 from a total of 67 reviews on Drugs.com. 60% of reviewers reported a positive experience, while 24% reported a negative experience.

Reviews for Prempro

Commonly mentioned side effects
  • T-N...
  • Taken for less than 1 month
  • September 21, 2021

For Postmenopausal Symptoms "Works great, transitioned to it from progesterone and estradiol and didn't notice any changes. The progesterone made me feel drunk, and I slept a little better. I still sleep a lot better than before HRT. I was waking up drenched with sweat and heat and then so cold after the flash."

8 / 10
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6 Report
  • Bel...
  • April 24, 2025

For Postmenopausal Symptoms "Yes, I have started taking Prempro about a week ago. This medication does not take long to see the symptoms of your hot flashes decrease, and sleeping habits are better. If you are not seeing any symptom change, you may need to up the mgs from 1.0 mg to 2.5 mg."

9 / 10
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0 Report
  • Mag...
  • Taken for 10 years or more
  • April 5, 2025

For Postmenopausal Symptoms "I feel extremely fortunate to have had a female MD at the time I hit menopause. I was 50, and my husband died around the same time menopause hit. My MD prescribed Prempro 0.3/1.5, and I believe this has kept my body healthy for the past 19 years, and yes, I am still taking Prempro today. I still maintain a healthy sex life (with my long-term partner), my bone density is good, and my overall health is very good. My gynecologist refused to prescribe this many years ago, but my PCP continues to prescribe this for me. All my friends are just now learning about the health benefits of HRT, for many, it is too late, and some prefer to use bioidentical or natural hormones. Prempro helped me through my grief, it helped with hot flashes and night sweats, and helped prevent weight gain. It is very expensive, hopefully a generic someday soon! I will reach out to Pfizer to see about some sort of discount."

9 / 10
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0 Report
  • Din...
  • February 18, 2020

For Postmenopausal Symptoms "I had frequent UTIs and hot flashes, also terrible vaginal dryness. After starting Prempro, I have no more of these symptoms. So happy this helped me."

10 / 10
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55 Report
  • My3...
  • October 30, 2011

For Postmenopausal Symptoms "I have been using Prempro for about 1 1/2 months, and it has taken away the hot flashes on the 1st day! The only symptom I have had is tenderness in the breast area. Hope it keeps working."

9 / 10
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60 Report

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  • cya...
  • Taken for 1 to 6 months
  • October 30, 2019

For Postmenopausal Symptoms "I had started to give up that Prempro would alleviate my hot flashes and night sweats, but lo and behold... at 8 weeks of use, they subsided! It was worth the wait as I feel great :)"

10 / 10
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30 Report
  • Luc...
  • Taken for 1 to 6 months
  • September 16, 2019

For Postmenopausal Symptoms "I'm 52 years old, I started Prempro about a month ago and love it, no more hot flashes. I'm sleeping now, only problem for me is now I'm spotting."

10 / 10
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28 Report
  • Anonymous
  • March 17, 2011

For Postmenopausal Symptoms "I have been using this medicine for 1 year for hot flashes, and now I have developed sore breasts. Otherwise, this medicine is great, no more hot flashes. Have to use vaginal cream also."

9 / 10
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40 Report
  • deb...
  • July 29, 2016

For Postmenopausal Symptoms "No sleeping without Prempro .0625, but I cannot reasonably continue to pay the outrageous, escalating price! Have nothing that helps pay for it. The price goes up almost monthly."

2 / 10
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25 Report
  • Kim...
  • January 20, 2020

For Postmenopausal Symptoms "Tried every over-the-counter possible! Pharmacist said this should start working right away. Nine days in, NIGHT SWEATS still 100%. Seems I’m sleeping longer at a time. Giving it 2 months $$$$$$$."

2 / 10
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14 Report
  • Anonymous
  • October 26, 2011

"Suffered depression symptoms, as I continued medication, depression got worse. Stopped taking it, and it took one week for depression to diminish."

1 / 10
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26 Report
  • Car...
  • Taken for 1 to 6 months
  • October 16, 2019

For Postmenopausal Symptoms "I've been taking Prempro for 2 months, no more hot flashes, and I'm sleeping now. The only con is I've been bleeding lightly for 2 to three weeks, and my breast hurts. I think I'm done."

6 / 10
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13 Report
  • Ouc...
  • Taken for 1 to 6 months
  • June 24, 2017

For Postmenopausal Symptoms "Suffered from decreased mental ability, probably due to hot flashes that would last all day. Have been taking Prempro for 5 months and am now experiencing some pretty major depression."

4 / 10
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16 Report
  • Anonymous
  • Taken for 1 to 6 months
  • July 6, 2015

"Has not worked one bit, still have day and night sweats occurring every hour."

1 / 10
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16 Report
  • Sue...
  • February 16, 2020

For Postmenopausal Symptoms "First night, I sweated all night. Is this a bad sign?"

1 / 10
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6 Report
  • Kri...
  • August 9, 2016

For Postmenopausal Symptoms "I had a heavy, painful period and was clotty. Also, breast tenderness. I needed to stop this medicine after being on it just one month."

2 / 10
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9 Report
  • JCa...
  • February 28, 2020

For Postmenopausal Symptoms "Ladies, breast cancer is a side effect of taking this. I would rather suffer with night sweats for the rest of my life, I cannot believe someone would take this risk knowing the facts."

1 / 10
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20 Report

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Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.