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Medications for Muscle Spasm (Involuntary Hypertonicity)

Drugs associated with Muscle Spasm

The following drugs and medications are in some way related to, or used in the treatment of this condition.

What is Muscle Spasm: Painful involuntary muscle contractions. Often seen in skeletal muscle after acute injury

Drug name Rx / OTC Pregnancy CSA Alcohol Reviews Rating Popularity
Flexeril Rx B N X 85 reviews
6.0

Generic name: cyclobenzaprine systemic

Drug class: skeletal muscle relaxants

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

 
cyclobenzaprine Rx B N X 184 reviews
6.0

Generic name: cyclobenzaprine systemic

Brand names:  Flexeril, Amrix, Comfort Pac with Cyclobenzaprine, Fexmid

Drug class: skeletal muscle relaxants

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

 
Soma Rx C 4 X 120 reviews
9.0

Generic name: carisoprodol systemic

Drug class: skeletal muscle relaxants

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

 
baclofen Rx C N X 75 reviews
7.0

Generic name: baclofen systemic

Brand names:  Lioresal, Kemstro, Lioresal Intrathecal

Drug class: skeletal muscle relaxants

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

 
tizanidine Rx C N X 130 reviews
7.0

Generic name: tizanidine systemic

Brand name:  Zanaflex

Drug class: skeletal muscle relaxants

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

 
Zanaflex Rx C N X 72 reviews
7.0

Generic name: tizanidine systemic

Drug class: skeletal muscle relaxants

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

 
methocarbamol Rx C N X 113 reviews
6.0

Generic name: methocarbamol systemic

Brand names:  Robaxin, Robaxin-750

Drug class: skeletal muscle relaxants

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

 
Valium Rx D 4 X 29 reviews
8.0

Generic name: diazepam systemic

Drug class: benzodiazepines, benzodiazepine anticonvulsants

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

 
diazepam Rx D 4 X 64 reviews
8.0

Generic name: diazepam systemic

Brand names:  Valium, Diazepam Intensol, Diastat, Diastat AcuDial, Diastat Pediatric

Drug class: benzodiazepines, benzodiazepine anticonvulsants

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

 
Skelaxin Rx N N X 53 reviews
7.0

Generic name: metaxalone systemic

Drug class: skeletal muscle relaxants

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

 
Robaxin Rx C N X 35 reviews
6.0

Generic name: methocarbamol systemic

Drug class: skeletal muscle relaxants

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

 
carisoprodol Rx C 4 X 150 reviews
8.0

Generic name: carisoprodol systemic

Brand names:  Soma, Vanadom

Drug class: skeletal muscle relaxants

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

 
Amrix Rx B N X 27 reviews
7.0

Generic name: cyclobenzaprine systemic

Drug class: skeletal muscle relaxants

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

 
Robaxin-750 Rx C N X 20 reviews
5.0

Generic name: methocarbamol systemic

Drug class: skeletal muscle relaxants

For consumers: dosage, interactions, side effects

 
Diazepam Intensol Rx D 4 X 2 reviews
9.0

Generic name: diazepam systemic

Drug class: benzodiazepines, benzodiazepine anticonvulsants

For consumers: dosage, interactions, side effects

 
Diastat Rx D 4 X 1 review
10

Generic name: diazepam systemic

Drug class: benzodiazepines, benzodiazepine anticonvulsants

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

 
Lioresal Rx C N X 7 reviews
7.0

Generic name: baclofen systemic

Drug class: skeletal muscle relaxants

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

 
Norflex Rx C N X 12 reviews
6.0

Generic name: orphenadrine systemic

Drug class: skeletal muscle relaxants

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

 
metaxalone Rx N N X 62 reviews
7.0

Generic name: metaxalone systemic

Brand names:  Skelaxin, Metaxall

Drug class: skeletal muscle relaxants

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

 
Comfort Pac with Cyclobenzaprine Rx B N X 2 reviews
4.0

Generic name: cyclobenzaprine systemic

Drug class: skeletal muscle relaxants

For consumers: dosage, interactions, side effects

 
Fexmid Rx B N X 3 reviews
7.0

Generic name: cyclobenzaprine systemic

Drug class: skeletal muscle relaxants

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

 
orphenadrine Rx C N X 23 reviews
6.0

Generic name: orphenadrine systemic

Brand names:  Norflex, Antiflex, Mio-Rel, Orfro, Orphenate

Drug class: skeletal muscle relaxants

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

 
Soma Compound Rx C 4 X 8 reviews
9.0

Generic name: aspirin / carisoprodol systemic

Drug class: skeletal muscle relaxant combinations

For consumers: dosage, interactions, side effects

 
chlorzoxazone Rx N N X 34 reviews
7.0

Generic name: chlorzoxazone systemic

Brand names:  Lorzone, Parafon Forte DSC, Remular-S

Drug class: skeletal muscle relaxants

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

 
Lorzone Rx N N X 15 reviews
6.0

Generic name: chlorzoxazone systemic

Drug class: skeletal muscle relaxants

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

 
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Topics under Muscle Spasm

Alternative treatments for Muscle Spasm

The following products are considered to be alternative treatments or natural remedies for Muscle Spasm. Their efficacy may not have been scientifically tested to the same degree as the drugs listed in the table above. However there may be historical, cultural or anecdotal evidence linking their use to the treatment of Muscle Spasm.

Learn more about Muscle Spasm (Involuntary Hypertonicity)

Legend

Off Label This medication may not be approved by the FDA for the treatment of this condition.
Prescription Only / Over the Counter
Rx Prescription Only
OTC Over the Counter
Rx/OTC Prescription or Over the Counter
Pregnancy
A Adequate and well-controlled studies have failed to demonstrate a risk to the fetus in the first trimester of pregnancy (and there is no evidence of risk in later trimesters).
B Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.
C Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.
D There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.
X Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use of the drug in pregnant women clearly outweigh potential benefits.
N FDA has not classified the drug.
Controlled Substances Act Schedule
N The drug is not subject to the Controlled Substances Act.
1 The drug has a high potential for abuse. The drug has no currently accepted medical use in treatment in the United States. There is a lack of accepted safety for use of the drug under medical supervision.
2 The drug has a high potential for abuse. The drug has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse of the drug may lead to severe psychological or physical dependence.
3 The drug has a potential for abuse less than the drugs in schedules 1 and 2. The drug has a currently accepted medical use in treatment in the United States. Abuse of the drug may lead to moderate or low physical dependence or high psychological dependence.
4 The drug has a low potential for abuse relative to the drugs in schedule 3. The drug has a currently accepted medical use in treatment in the United States. Abuse of the drug may lead to limited physical dependence or psychological dependence relative to the drugs in schedule 3.
5 The drug has a low potential for abuse relative to the drugs in schedule 4. The drug has a currently accepted medical use in treatment in the United States. Abuse of the drug may lead to limited physical dependence or psychological dependence relative to the drugs in schedule 4.
Alcohol
X Interacts with Alcohol.

Synonym(s): Charley horse; Spasms

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