Class: Centrally Acting Skeletal Muscle Relaxants
VA Class: MS200
CAS Number: 95-25-0
Brands: Parafon Forte DSC
Centrally acting skeletal muscle relaxant.b
Uses for Chlorzoxazone
If pharmacologic therapy is required for acute low back pain (usually a benign and self-limiting condition105 106 108 ), an analgesic (e.g., acetaminophen, NSAIA) generally is recommended.104 105 106 108 117 Skeletal muscle relaxants may be used alone or in combination with analgesics for short-term relief; however, consider high incidence of adverse effects (e.g., CNS effects).104 106 107 108 Use skeletal muscle relaxants with caution and weigh risks against benefits.104 106 107 108
Chlorzoxazone is ineffective in the treatment of skeletal muscle hyperactivity secondary to chronic neurologic disorders (e.g., cerebral palsy) and other dyskinesias.b
Chlorzoxazone Dosage and Administration
Usual adult dosage: 250 mg 3–4 times daily.i
Cautions for Chlorzoxazone
Serious, possibly fatal, hepatotoxicity reported rarely; may be associated with increased serum AST, ALT, alkaline phosphatase, and bilirubin concentrations and increased sulfobromophthalein sodium (BSP) retention.100 101 102 Mechanism unknown but appears idiosyncratic and unpredictable.100 101 102
Perform liver function tests periodically in patients receiving long-term therapy.101
If elevated liver function tests or bilirubin reported or if signs and symptoms of hepatic dysfunction (e.g., fever, rash, anorexia, nausea/vomiting, fatigue, right upper quadrant pain, dark urine, or jaundice) occur, discontinue chlorzoxazone immediately.100 102 a
Sensitivity reactions (e.g., urticaria, redness, petechiae, pruritus) reported rarely; angioedema and anaphylactic reactions are extremely rare.a i Use with caution in patients with allergies or with a history of allergic drug reactions.a b i
Not known whether chlorzoxazone is distributed into milk; use with caution.b
Common Adverse Effects
Interactions for Chlorzoxazone
CNS depressants (e.g., alcohol, barbiturates)
Usually within 1 hour.b
In dogs, found in plasma and fat; also present in liver, muscle, brain, and kidneys.b
Not known whether chlorzoxazone crosses the placenta or is distributed into milk.b
Rapidly metabolized in the liver to 6-hydroxychlorzoxazone, an inactive metabolite.b
CNS depressant with sedative and skeletal muscle relaxant effects.b
Inhibits multisynaptic reflex arcs at the level of the spinal cord and subcortical areas of the brain; results in reduction of skeletal muscle spasm with relief of pain and increased mobility of involved muscles.a i
Advice to Patients
Importance of informing clinician if any early signs or symptoms of possible liver dysfunction (e.g., fatigue, anorexia, nausea and/or vomiting, fever, rash, jaundice, dark urine, right upper quadrant pain) occur.100 102
Importance of informing patients of other important precautionary information. (See Cautions.)
Excipients in commercially available drug preparations may have clinically important effects in some individuals; consult specific product labeling for details.
* available from one or more manufacturer, distributor, and/or repackager by generic (nonproprietary) name
Parafon Forte DSC Caplets (scored)
This pricing information is subject to change at the sole discretion of DS Pharmacy. This pricing information was updated 02/2013. Actual costs to patients will vary depending on the use of specific retail or mail-order locations and health insurance copays.
Chlorzoxazone 500MG Tablets (WATSON LABS): 90/$17.99 or 180/$24.98
Parafon Forte DSC 500MG Tablets (MCNEIL): 30/$92.99 or 90/$244.97
This report on medications is for your information only, and is not considered individual patient advice. Because of the changing nature of drug information, please consult your physician or pharmacist about specific clinical use.
The American Society of Health-System Pharmacists, Inc. and Drugs.com represent that the information provided hereunder was formulated with a reasonable standard of care, and in conformity with professional standards in the field. The American Society of Health-System Pharmacists, Inc. and Drugs.com make no representations or warranties, express or implied, including, but not limited to, any implied warranty of merchantability and/or fitness for a particular purpose, with respect to such information and specifically disclaims all such warranties. Users are advised that decisions regarding drug therapy are complex medical decisions requiring the independent, informed decision of an appropriate health care professional, and the information is provided for informational purposes only. The entire monograph for a drug should be reviewed for a thorough understanding of the drug's actions, uses and side effects. The American Society of Health-System Pharmacists, Inc. and Drugs.com do not endorse or recommend the use of any drug. The information is not a substitute for medical care.
AHFS Drug Information. © Copyright, 1959-2013, Selected Revisions November 19, 2012. American Society of Health-System Pharmacists, Inc., 7272 Wisconsin Avenue, Bethesda, Maryland 20814.
100. McNeil Pharmaceutical. Parafon Forte DSC (chlorzoxazone) prescribing information (dated 1994 Dec 8). In: Physicians’ desk reference. 48th ed. Montvale, NJ: Medical Economics Company Inc; 1996:1581.
101. Powers BJ, Cattau EL Jr, Zimmerman HJ. Chlorzoxazone hepatotoxic reactions. Arch Intern Med. 1986; 146:1183-6. [IDIS 217157] [PubMed 3521519]
102. McNeil Pharmaceutical. Paraflex (chlorzoxazone) prescribing information (dated 1994 Dec 8). In: Physicians’ desk reference. 50th ed. Montvale, NJ: Medical Economics Company Inc; 1996:1580-1.
103. See S, Ginzburg R. Skeletal muscle relaxants. Pharmacotherapy. 2008; 28:207-13. [PubMed 18225966]
104. van Tulder MW, Touray T, Furlan AD et al. Muscle relaxants for non-specific low back pain. Cochrane Database Syst Rev. 2003; :CD004252. [PubMed 12804507]
105. Roelofs PD, Deyo RA, Koes BW et al. Non-steroidal anti-inflammatory drugs for low back pain. Cochrane Database Syst Rev. 2008; :CD000396. [PubMed 18253976]
106. Chou R, Qaseem A, Snow V et al. Diagnosis and treatment of low back pain: a joint clinical practice guideline from the American College of Physicians and the American Pain Society. Ann Intern Med. 2007; 147:478-91. [PubMed 17909209]
107. Institute for Clinical Systems Improvement. Health care guideline: adult acute and subacute low back pain. 15th ed. Bloomington, MN; 2012 Jan. From the ICSI website
108. Toth PP, Urtis J. Commonly used muscle relaxant therapies for acute low back pain: a review of carisoprodol, cyclobenzaprine hydrochloride, and metaxalone. Clin Ther. 2004; 26:1355-67. [PubMed 15530999]
117. Boothby LA, Doering PL, Hatton RC. Carisoprodol: a marginally effective skeletal muscle relaxant with serious abuse potential. Hosp Pharm. 2003; 38:337-45.
a. Ortho-McNeil. Parafon Forte DSC caplets prescribing information. Raritan, NJ; 2000 Aug.
b. AHFS drug information 2006. McEvoy GK, ed. Chloroxazone. Bethesda, MD: American Society of Health-System Pharmacists; 2006:[1385-6.].
i. Amide Pharmaceutical, Inc. Chlorzoxazone tablets prescribing information. Little Falls, NJ: 2002 Apr.
More Chlorzoxazone resources
- Chlorzoxazone Prescribing Information (FDA)
- Chlorzoxazone Professional Patient Advice (Wolters Kluwer)
- chlorzoxazone Concise Consumer Information (Cerner Multum)
- chlorzoxazone MedFacts Consumer Leaflet (Wolters Kluwer)
- chlorzoxazone Advanced Consumer (Micromedex) - Includes Dosage Information
- Parafon Forte DSC Prescribing Information (FDA)