Orphenadrine Side Effects
Some side effects of orphenadrine may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
For the Consumer
Applies to orphenadrine: oral tablet extended release
Get emergency medical help if you have any of these signs of an allergic reaction while taking orphenadrine: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop using orphenadrine and call your doctor at once if you have any of these serious side effects:
fast, pounding, or uneven heartbeats;
confusion, anxiety, agitation, tremors, hallucinations;
seizure (convulsions); or
urinating less than usual or not at all.
Less serious side effects of orphenadrine may include:
dry mouth or throat;
blurred vision, dilated pupils;
nausea, vomiting, constipation; or
This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect.
For Healthcare Professionals
Applies to orphenadrine: compounding powder, injectable solution, oral tablet extended release
Nervous system side effects have included headache, light-headedness, dizziness, drowsiness, syncope and tremor. Infrequently, elderly patients have experienced mental confusion.
Ocular side effects have included blurred vision, dilatation of pupils, and increased ocular tension.
Cardiovascular side effects have included tachycardia and palpitations.
Genitourinary side effects have included urinary hesitancy and retention.
Gastrointestinal side effects have included dry mouth, nausea, vomiting, and gastric irritation.
Musculoskeletal side effects have included weakness.
Dermatologic side effects have included pruritus, and rarely, urticaria and other dermatosis.
Psychiatric side effects have included hallucinations and agitation.
Hematologic side effects have included very rare cases of aplastic anemia, however, no causal relationship has been established.
More orphenadrine resources
- orphenadrine Concise Consumer Information (Cerner Multum)
- orphenadrine MedFacts Consumer Leaflet (Wolters Kluwer)
- orphenadrine Advanced Consumer (Micromedex) - Includes Dosage Information
- Antiflex Advanced Consumer (Micromedex) - Includes Dosage Information
- Norflex Prescribing Information (FDA)
- Norflex Monograph (AHFS DI)
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