Orphenadrine Side Effects

Please note - some side effects for Orphenadrine may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

Side Effects of Orphenadrine - for the Consumer

Orphenadrine

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Orphenadrine:

Blurred vision; constipation; dizziness or lightheadedness; drowsiness; dry mouth; headache; nausea; stomach irritation or upset; vomiting; weakness.

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); agitation, chills, fever, or sore throat; confusion; fainting; fast or irregular heartbeat; hallucinations; pain, swelling, or redness the injection site; severe or persistent tiredness or weakness; tremor; trouble urinating or inability to urinate; unusual bruising or bleeding; vision changes.

Orphenadrine Extended-Release Tablets

All medicines may cause side effects, but many people have no, or minor side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Orphenadrine Extended-Release Tablets:

Blurred vision; constipation; dizziness or lightheadedness; drowsiness; dry mouth; headache; nausea; stomach irritation or upset; vomiting; weakness.

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); agitation; chills, fever, or sore throat; confusion; fainting; fast or irregular heartbeat; hallucinations; severe or persistent tiredness or weakness; tremor; trouble urinating or inability to urinate; unusual bruising or bleeding; vision changes.

Orphenadrine Side Effects - for the Professional

Orphenadrine Extended release tablets

Adverse reactions of Orphenadrine are mainly due to the mild anticholinergic action of Orphenadrine, and are usually associated with higher dosage. Dryness of the mouth is usually the first adverse effect to appear. When the daily dose is increased, possible adverse effects include tachycardia, palpitation, urinary hesitancy or retention, blurred vision, dilatation of pupils, increased ocular tension, weakness, nausea, vomiting, headache, dizziness, constipation, drowsiness, hypersensitivity reactions, pruritus, hallucinations, agitation, tremor, gastric irritation, and rarely urticaria and other dermatoses. Infrequently, an elderly patient may experience some degree of mental confusion. These adverse reactions can usually be eliminated by reduction in dosage. Very rare cases of aplastic anemia associated with the use of Orphenadrine tablets have been reported. No causal relationship has been established.

Orphenadrine Injection

Adverse reactions of Orphenadrine are mainly due to the mild anticholinergic action of Orphenadrine, and are usually associated with higher dosage. Dryness of the mouth is usually the first adverse effect to appear. When the daily dose is increased, possible adverse effects include: tachycardia, palpitation, urinary hesitancy or retention, blurred vision, dilatation of pupils, increased ocular tension, weakness, nausea, vomiting, headache, dizziness, constipation, drowsiness, hypersensitivity reactions, pruritus, hallucinations, agitation, tremor, gastric irritation, and rarely urticaria and other dermatoses. Infrequently, an elderly patient may experience some degree of mental confusion. These adverse reactions can usually be eliminated by reduction in dosage. Very rare cases of aplastic anemia associated with the use of Orphenadrine tablets have been reported. No causal relationship has been established.

Rare instances of anaphylactic reaction have been reported associated with the intramuscular injection of Orphenadrine citrate.

Side Effects by Body System

Nervous system

Nervous system side effects have included headache, light-headedness, dizziness, drowsiness, syncope and tremor. Infrequently, elderly patients have experienced mental confusion.

Ocular

Ocular side effects have included blurred vision, dilatation of pupils, and increased ocular tension.

Cardiovascular

Cardiovascular side effects have included tachycardia and palpitations.

Genitourinary

Genitourinary side effects have included urinary hesitancy and retention.

Gastrointestinal

Gastrointestinal side effects have included dry mouth, nausea, vomiting, and gastric irritation.

Musculoskeletal

Musculoskeletal side effects have included weakness.

Dermatologic

Dermatologic side effects have included pruritus, and rarely, urticaria and other dermatosis.

Psychiatric

Psychiatric side effects have included hallucinations and agitation.

Hematologic

Hematologic side effects have included very rare cases of aplastic anemia, however, no causal relationship has been established.

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