Pronunciation: vii-joiz
Generic name: alpelisib
Dosage form: oral tablets, oral granules
Drug class: PI3K inhibitors

Medically reviewed by Judith Stewart, BPharm. Last updated on Apr 29, 2024.

What is Vijoice?

Vijoice (alpelisib) is an oral kinase inhibitor that may be used to treat severe phosphatidylinositol-3-kinase catalytic subunit alpha (PIK3CA)-Related Overgrowth Spectrum (PROS) in adults and children aged 2 years and older. It is taken once a day.

PROS is a spectrum of rare conditions characterized by abnormal overgrowth and structural abnormalities in blood vessels, the lymphatic system, and other tissues.

Vijoice works by inhibiting the PI3K pathway, one of the most important intracellular pathways involved in cell proliferation, cell regulation, and cell death. Mutations in this pathway have been found to cause a range of overgrowth and malformations that comprise the range of disorders commonly known as PROS. 

Vijoice was approved on April 6, 2022, under an accelerated approval designation. Continued approval may be subject to favorable results from further clinical trials.

Who should not take Vijoice?

You should not take Vijoice if you have had a severe allergic reaction to alpelisib or are allergic to any of the ingredients.

• See the end of this page for a complete list of the ingredients.
• See Vijoice side effects for signs and symptoms of severe allergic reactions.

It is not known if this medicine is safe and effective in children below 2 years of age.

Related/similar drugs

alpelisib

Before you take Vijoice

Before you start treatment, tell your healthcare provider about all of your medical conditions, including if you:

• have a history of diabetes.
• have a history of skin rash, redness of skin, blistering of the lips, eyes or mouth, or skin peeling.
• are pregnant or plan to become pregnant. Vijoice can harm your unborn baby.
  Females who are able to become pregnant:
  • Your healthcare provider will check to see if you are pregnant before you start treatment.
  • You should use effective birth control during treatment, and for 1 week after the last dose. Talk to your healthcare provider about birth control methods that may be right for you during this time.
  • If you become pregnant or think you are pregnant, tell your healthcare provider right away.

Males with female partners who are able to become pregnant should use condoms and effective birth control during treatment, and for 1 week after the last dose. If your female partner becomes pregnant, tell your healthcare provider right away.

• are breastfeeding or plan to breastfeed. It is not known if Vijoice passes into your breast milk. Do not breastfeed during treatment, and for 1 week after the last dose.

What other drugs will affect Vijoice?

Tell your healthcare provider about all of the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Vijoice and other medicines may affect each other causing side effects. Know the medicines you take. Keep a list of them to show your healthcare provider or pharmacist when you get
a new medicine.

How should I take Vijoice?

• Take Vijoice exactly as your healthcare provider tells you.
• Do not change your dose or stop treatment unless your healthcare provider tells you.
• If your prescribed daily dose is 50mg, your healthcare provider can prescribe either tablets or oral granules.
• If your prescribed dose is 125mg or 250mg, you will be prescribed Vijoice tablets.

Vijoice tablets

• Take Vijoice tablets 1 time each day, at about the same time every day.
• Take the tablets with food.
• Swallow the tablets whole. Do not split or chew the tablets.
• Do not take tablets that are broken, cracked or that look damaged at the time of opening the blister pack.
• If you cannot swallow tablets whole, you can take them mixed with water (suspension) as follows:
  • Place the tablets into a glass that contains 2 to 4 ounces of water and let it stand for about 5 minutes.
    Use water only.
  • Crush the tablets with a spoon and stir to dissolve. The liquid will be cloudy and you may see tablet pieces.
  • Swallow the mixture right away.
  • Next, add about 2 to 3 tablespoons of water to the same glass and stir with the same spoon. Then swallow the entire contents of the glass to ensure the entire dose is consumed. Repeat this step if necessary.
  • Throw away any of the mixture that is not taken within 60 minutes after it is prepared.
• If you miss a dose, you may still take it with food up to 9 hours after the time you usually take it. If it has been more than 9 hours after you usually take your dose, skip the dose for that day. The next day, take the dose at your usual time. Do not take 2 doses to make up for a missed dose.
• If you vomit after taking a dose, do not take another dose on that day. Take your next dose at your usual time.
• If you take too much or overdose, call your healthcare provider or go to the nearest hospital emergency room right away.

Vijoice oral granules

Each packet is for single use only. Do not use the packet if the packet seal is broken.

Open the packet of Vijoice oral granules by holding them with the cut line on top.

• Shake the packet gently to ensure the granules are in the lower part of the packet.
• Using scissors, open the packet along the cut line.

Vijoice oral granules may be taken in one of the following ways:

• Pour the oral granules from 1 packet directly onto the tongue by tapping the side and top of the packet and then swallowing with about 4 to 8 tablespoons (2 to 4 ounces) of water.  If there is any medicine remaining in the mouth, rinse the mouth with additional water and swallow to make sure the entire dose is taken
  OR
• Pour the oral granules from 1 packet into a cup by tapping the side and top of the packet. Add 1 to 3 teaspoons (about 0.5 ounces) of a beverage (water, milk, or apple juice) or soft food (applesauce or yogurt) and take the mixture right away. Rinse the cup with up to 4 tablespoons (2 ounces) of water, milk or apple juice. Take the mixture right away to make sure the entire dose is taken. Repeat this step until there is no medicine remaining in the cup. Throw away any granules mixed with water, milk, apple juice, applesauce, or yogurt that is not taken within 2 hours after it is prepared.

Dosing information

Usual Adult Dosage for PIK3CA-Related Overgrowth Spectrum

• 250 mg taken orally once daily with food.

Usual Pediatric Dosage for PIK3CA-Related Overgrowth Spectrum

• 50 mg taken orally once daily with food.

Vijoice side effects

Vijoice may cause serious side effects, including:

• Severe allergic reactions. Tell your healthcare provider or get medical help right away if you have trouble breathing, flushing, rash, fever, or fast heart rate during treatment.
• Severe skin reactions. Tell your healthcare provider or get medical help right away if you get severe rash or rash that keeps getting worse, reddened skin, flu-like symptoms, blistering of the lips, eyes or mouth, blisters on the skin or skin peeling, with or without fever.
• High blood sugar levels (hyperglycemia). Hyperglycemia is common with Vijoice and can be severe. Your healthcare provider will monitor your sugar levels before you start, and during treatment. Your healthcare provider may monitor your sugar levels more often if you have a history of diabetes. Tell your healthcare provider right away if you develop symptoms of hyperglycemia, including:
  • excessive thirst
  • dry mouth
  • more frequent urination than usual or a higher amount of urine than normal
  • increased appetite with weight loss
  • confusion
  • nausea
  • vomiting
  • fruity odor on breath
  • difficulty breathing
  • dry or flushed skin
• Lung problems (pneumonitis). Tell your healthcare provider right away if you develop new or worsening symptoms of lung problems, including:
  • shortness of breath or trouble breathing
  • cough
  • chest pain
• Diarrhea. Diarrhea is common with Vijoice and can be severe. Severe diarrhea can lead to the loss of too much body water (dehydration) and kidney injury. Tell your healthcare provider right away if you develop diarrhea during treatment. Your healthcare provider may tell you to drink more fluids or take medicines to treat diarrhea.

Your healthcare provider may tell you to decrease your dose, temporarily stop your treatment, or completely stop your treatment if you get certain serious side effects.

The most common side effects affecting 10% or more people include:

• diarrhea
• high blood sugar
• dry skin
• mouth sores (stomatitis)
• headache
• hair loss (alopecia).

Vijoice may affect fertility in males and in females who can become pregnant. Talk to your healthcare provider if this is a concern for you. These are not all of the possible side effects. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

How should I store Vijoice?

• Store Vijoice at 20°C to 25°C (68°F to 77°F), excursions permitted between 15°C and 30°C (59°F and 86°F).

Keep all medicines out of the reach of children and pets.

What are the ingredients in Vijoice?

Vijoice tablets

Active ingredient: alpelisib
Inactive ingredients: hypromellose, magnesium stearate, mannitol, microcrystalline cellulose, and sodium starch glycolate.

The film-coating contains hypromellose, iron oxide red (applicable only to 50 mg and 200 mg strengths), iron oxide yellow, macrogol/polyethylene glycol (PEG) 4000, talc, and titanium dioxide.

Vijoice oral granules

Active ingredient: alpelisib
Inactive ingredients: hypromellose, magnesium stearate, mannitol, microcrystalline cellulose, and sodium starch glycolate.

Manufacturer

Novartis Pharmaceuticals Corporation.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer