Methocarbamol Side Effects

Not all side effects for methocarbamol may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to methocarbamol: oral tablet

Other dosage forms:

In addition to its needed effects, some unwanted effects may be caused by methocarbamol. In the event that any of these side effects do occur, they may require medical attention.

You should check with your doctor immediately if any of these side effects occur when taking methocarbamol:

Incidence not known
  • Abdominal or stomach pain
  • black, tarry stools
  • changes in skin color
  • chest pain or discomfort
  • chills
  • clay-colored stools
  • cough
  • dark urine
  • diarrhea
  • difficulty swallowing
  • dizziness
  • fast heartbeat
  • feeling of warmth
  • fever
  • headache
  • hives
  • itching
  • joint or muscle pain
  • large, hive-like swelling on face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • lightheadedness, dizziness, or fainting
  • loss of appetite
  • loss of bladder control
  • loss of consciousness
  • loss of memory
  • nausea
  • numbness or tingling of face, hands, or feet
  • pain, tenderness, or swelling of foot or leg
  • painful or difficult urination
  • problems with memory
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • redness and soreness of eyes
  • redness of the face, neck, arms, and occasionally, upper chest
  • relaxed and calm
  • shortness of breath
  • skin rash
  • sleepiness
  • slow or irregular heartbeat
  • sore throat
  • sores, ulcers, or white spots on lips or in mouth
  • swollen glands
  • tightness in chest
  • total body jerking
  • unpleasant breath odor
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • vomiting of blood
  • wheezing
  • yellow eyes or skin

If any of the following symptoms of overdose occur while taking methocarbamol, get emergency help immediately:

Symptoms of Overdose
  • Shaking or jerking of one area or side of the body
  • sweating

Some of the side effects that can occur with methocarbamol may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

Incidence not known
  • Acid or sour stomach
  • belching
  • double vision
  • drowsiness
  • feeling of constant movement of self or surroundings
  • heartburn
  • indigestion
  • mood or mental changes
  • seeing double
  • sensation of spinning
  • sleeplessness
  • stomach discomfort, upset, or pain
  • trouble sleeping
  • unable to sleep
  • uncontrolled eye movements

For Healthcare Professionals

Applies to methocarbamol: injectable solution, oral tablet

Cardiovascular

Cardiovascular side effects have included syncope, hypotension, and bradycardia.

Nervous system

Nervous system side effects have included dizziness, lightheadedness, vertigo, headache, drowsiness, fainting, and mild muscular incoordination. Convulsions have been reported with intravenous administration, especially in patients with a history of epilepsy.

Dermatologic

Dermatologic side effects have included urticaria, pruritus, rash, sloughing, thrombophlebitis, and pain at the injection site.

Ocular

Ocular side effects have included blurred vision, conjunctivitis, nystagmus, and diplopia.

Respiratory

Respiratory side effects have included nasal congestion, bronchospasm, and anaphylaxis.

Gastrointestinal

Gastrointestinal side effects have included gastrointestinal upset, anorexia, and adynamic ileus.

Other

Other side effects have included metallic taste and fever.

Effects on lab tests have included a possible color interference in certain screening tests for 5-hydroxyindoleacetic acid (5-HIAA) and vanillylmandelic acid (VMA).

Hematologic

Hematologic side effects have included hemolysis, particularly with intravenous injection.

Renal

Methocarbamol vials for injection contain polyethylene glycol 300 (PEG 300). Larger amounts of PEG 300 can increase preexisting renal acidosis and urea retention in patients with renal insufficiency.

Renal side effects including urine discoloration (black, blue, brown, or green) have been reported after oral administration in some patients.

General

General side effects have included angioneurotic edema.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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