Metaxalone Side Effects

Not all side effects for metaxalone may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to metaxalone: oral tablet

In addition to its needed effects, some unwanted effects may be caused by metaxalone. In the event that any of these side effects do occur, they may require medical attention.

You should check with your doctor immediately if any of these side effects occur when taking metaxalone:

More common
  • Abdominal or stomach pain
  • back or leg pains
  • black, tarry stools
  • bleeding gums
  • chest pain
  • chills
  • cough
  • dark urine
  • difficulty in breathing or swallowing
  • dizziness
  • fast heartbeat
  • fever
  • general body swelling
  • headache
  • itching
  • loss of appetite
  • nausea or vomiting
  • nosebleeds
  • painful or difficult urination
  • pale skin
  • rash
  • shortness of breath
  • skin itching, rash, or redness
  • sore throat
  • sores, ulcers, or white spots on the lips or in the mouth
  • swelling of the face, throat, or tongue
  • swollen glands
  • unpleasant breath odor
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • vomiting of blood
  • yellowing of the eyes or skin
Rare
  • Hives
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • tightness in the chest
  • wheezing

Some of the side effects that can occur with metaxalone may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common
  • Diarrhea
  • drowsiness
  • irritability
  • stomach cramps
  • vomiting

For Healthcare Professionals

Applies to metaxalone: oral tablet

Gastrointestinal

Gastrointestinal side effects including nausea, vomiting, and gastrointestinal upset have been reported.[Ref]

Nervous system

Nervous system side effects including drowsiness, dizziness, headache, and nervousness or irritability have been reported.[Ref]

Hematologic

Hematologic side effects including leukopenia and hemolytic anemia have been reported.[Ref]

Hypersensitivity

Hypersensitivity side effects including a hypersensitivity reaction characterized by a light rash with or without pruritus have been reported.[Ref]

Hepatic

Hepatic side effects including elevation in cephalin flocculation tests (without concurrent changes in other liver function parameters) and jaundice have been reported.[Ref]

Other

Other side effects including a false-positive Benedict's tests (due to an unknown reducing substance) have been reported.[Ref]

A glucose-specific test may be used to differentiate findings.[Ref]

References

1. "Product Information. Skelaxin (metaxalone)." Carnrick Laboratories Inc, Cedar Knolls, NJ.

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