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Metaxalone Side Effects

For the Consumer

Applies to metaxalone: oral tablet

In addition to its needed effects, some unwanted effects may be caused by metaxalone. In the event that any of these side effects do occur, they may require medical attention.

Severity: Major

You should check with your doctor immediately if any of these side effects occur when taking metaxalone:

More common
  • Abdominal or stomach pain
  • back or leg pains
  • black, tarry stools
  • bleeding gums
  • chest pain
  • chills
  • cough
  • dark urine
  • difficulty in breathing or swallowing
  • dizziness
  • fast heartbeat
  • fever
  • general body swelling
  • headache
  • itching
  • loss of appetite
  • nausea or vomiting
  • nosebleeds
  • painful or difficult urination
  • pale skin
  • rash
  • shortness of breath
  • skin itching, rash, or redness
  • sore throat
  • sores, ulcers, or white spots on the lips or in the mouth
  • swelling of the face, throat, or tongue
  • swollen glands
  • unpleasant breath odor
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • vomiting of blood
  • yellowing of the eyes or skin
Rare
  • Hives
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • tightness in the chest
  • wheezing

Severity: Minor

Some of the side effects that can occur with metaxalone may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common
  • Diarrhea
  • drowsiness
  • irritability
  • stomach cramps
  • vomiting

For Healthcare Professionals

Applies to metaxalone: oral tablet

Gastrointestinal

Common (1% to 10%): Nausea, vomiting, gastrointestinal upset[Ref]

Nervous system

Common (1% to 10%): Drowsiness, dizziness, headache[Ref]

Hematologic

Frequency not reported: Leukopenia, hemolytic anemia[Ref]

Hypersensitivity

Rare (less than 0.1%): Anaphylactoid reaction, hypersensitivity reaction, rash (with or without pruritus)[Ref]

Hepatic

Frequency not reported: Jaundice[Ref]

Other

Frequency not reported: False-positive Benedict's tests (due to an unknown reducing substance)[Ref]

A glucose-specific test may be used to differentiate findings.[Ref]

Psychiatric

Common (1% to 10%): Nervousness, irritability[Ref]

References

1. "Product Information. Skelaxin (metaxalone)." Carnrick Laboratories Inc, Cedar Knolls, NJ.

Not all side effects for metaxalone may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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