Xyzal Allergy 24HR Side Effects

Generic name: levocetirizine

Medically reviewed by Drugs.com. Last updated on Jan 27, 2025.

Note: This document provides detailed information about Xyzal Allergy 24HR Side Effects associated with levocetirizine. Some dosage forms listed on this page may not apply specifically to the brand name Xyzal Allergy 24HR.

Applies to levocetirizine: oral solution, oral tablet.

Common side effects of Xyzal Allergy 24HR

Some side effects of levocetirizine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common side effects

• muscle aches
• sleepiness or unusual drowsiness
• sore throat
• stuffy or runny nose

Less common side effects

• body aches or pain
• dryness of the throat
• earache
• hoarseness
• redness or swelling in the ear
• tender, swollen glands in the neck
• voice changes
• change in or loss of taste
• difficulty in moving
• increased appetite
• joint pain or swelling
• muscle pain, cramp, or stiffness
• nightmares

Serious side effects of Xyzal Allergy 24HR

Along with its needed effects, levocetirizine (the active ingredient contained in Xyzal Allergy 24HR) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking levocetirizine:

Less common side effects

• fever
• nosebleed

Incidence not known

• anxiety
• attack, assault, or force
• bloody, cloudy, or dark urine
• blurred or loss of vision
• burning feeling while urinating
• burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
• chills
• clay-colored stools
• confusion
• cough
• decrease in the frequency of urination
• decrease in urine volume
• deep or fast breathing with dizziness
• diarrhea
• difficult or labored breathing
• difficulty in passing urine (dribbling)
• difficulty with swallowing or speaking
• discouragement
• disturbed color perception
• dizziness, fainting, or lightheadedness when getting up suddenly from a lying or sitting position
• double vision
• drooling
• dry mouth
• fast, irregular, pounding, or racing heartbeat or pulse
• feeling of constant movement of self or surroundings
• feeling sad or empty
• fixed position of the eye
• general tiredness and weakness
• halos around lights
• headache
• hives or welts, itching, skin rash
• inability to move the eyes
• increased blinking or spasms of the eyelid
• irritability
• joint or muscle pain
• lack of appetite
• large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or genitals
• light-colored stools
• loss of balance control
• loss of interest or pleasure
• muscle trembling, twitching, jerking, or stiffness
• nausea
• nervousness
• night blindness
• numbness of the feet, hands, and around the mouth
• overbright appearance of lights
• painful urination
• puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
• redness of the skin
• restlessness
• rhythmic movement of the muscles
• seeing, hearing, or feeling things that are not there
• seizures
• sensation of spinning
• shaking
• shuffling walk
• sticking out of the tongue
• stomach pain
• swelling of the face, feet, or lower legs
• thoughts of killing oneself
• tightness in the chest
• tremor
• trouble concentrating
• trouble with sleeping
• tunnel vision
• twisting movements of the body
• uncontrolled movements, especially of the face, mouth, tongue, neck, and back
• uncontrolled twisting movements of the neck, trunk, arms, or legs
• unpleasant breath odor
• unusual facial expressions
• unusual tiredness or weakness
• upper right stomach pain
• vomiting with or without blood
• weight gain
• yellow eyes and skin

For healthcare professionals

Applies to levocetirizine: oral solution, oral tablet.

General adverse events

The most frequently reported side effects were: somnolence, nasopharyngitis, fatigue, dry mouth, and pharyngitis (in 12 years and older); pyrexia, somnolence, cough, and epistaxis (in patients 6 to 12 years); pyrexia, diarrhea, vomiting, and otitis media (in patients 1 to 5 years); diarrhea and constipation (in patients 6 to 11 months).^[Ref]

Nervous system

• Common (1% to 10%): Somnolence, dizziness, headache
• Uncommon (0.1% to 1%): Paresthesia, syncope
• Rare (0.01% to 0.1%): Convulsion, movement disorder
• Very rare (less than 0.01%): Dysgeusia, tremor, dystonia, dyskinesia
• Frequency not reported: Orofacial dyskinesia, myoclonus, extrapyramidal symptoms
• Postmarketing reports: Febrile seizure^[Ref]

Ocular

• Very rare (less than 0.01%): Accommodation disorder, vision blurred, oculogyration
• Postmarketing reports: Visual disturbance^[Ref]

Respiratory

• Common (1% to 10%): Nasopharyngitis, pharyngitis, cough, epistaxis, rhinitis
• Postmarketing reports: Dyspnea^[Ref]

Gastrointestinal

• Common (1% to 10%): Dry mouth, diarrhea, vomiting, constipation, abdominal pain
• Postmarketing reports: Nausea^[Ref]

Other

• Common (1% to 10%): Fatigue, pyrexia, otitis media
• Uncommon (0.1% to 1%): Weight increased, asthenia, malaise
• Rare (less than 0.1%): Edema
• Frequency not reported: Stillbirth
• Postmarketing reports: Vertigo^[Ref]

Psychiatric

• Uncommon (0.1% to 1%): Agitation
• Rare (0.01% to 0.1%): Aggression, confusion, depression, hallucination, insomnia
• Very rare (less than 0.01%): Tic, enuresis
• Postmarketing reports: Suicidal ideation, nightmare^[Ref]

Genitourinary

• Very rare (less than 0.01%): Dysuria
• Postmarketing reports: Urinary retention^[Ref]

Cardiovascular

• Rare (less than 0.1%): Tachycardia
• Frequency not reported: Severe hypotension
• Postmarketing reports: Palpitation^[Ref]

Dermatologic

• Uncommon (0.1% to 1%): Pruritus, rash
• Rare (0.01% to 0.1%): Urticaria
• Very rare (less than 0.01%): Angioedema, fixed drug eruption
• Frequency not reported: Acute generalized exanthematous pustulosis^[Ref]

Hepatic

• Rare (less than 0.1%): Hepatic function abnormal, transaminases increased, bilirubin increased
• Frequency not reported: Cholestasis
• Postmarketing reports: Hepatitis^[Ref]

Hematologic

• Very rare (less than 0.01%): Thrombocytopenia^[Ref]

Immunologic

• Rare (0.01% to 0.1%): Hypersensitivity
• Very rare (less than 0.01%): Anaphylactic shock^[Ref]

Renal

• Frequency not reported: Glomerulonephritis^[Ref]

Metabolic

• Postmarketing reports: Appetite increased^[Ref]

Musculoskeletal

• Postmarketing reports: Myalgia, arthralgia^[Ref]

Frequently asked questions

• Is Xyzal available over-the-counter?

Further information

Xyzal Allergy 24HR side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer