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Duexis Side Effects

Generic Name: famotidine / ibuprofen

Note: This page contains information about the side effects of famotidine / ibuprofen. Some of the dosage forms included on this document may not apply to the brand name Duexis.

For the Consumer

Applies to famotidine / ibuprofen: oral tablet

In addition to its needed effects, some unwanted effects may be caused by famotidine / ibuprofen. In the event that any of these side effects do occur, they may require medical attention.

Major Side Effects

You should check with your doctor immediately if any of these side effects occur when taking famotidine / ibuprofen:

Less common:
  • Abdominal or stomach pain, cramping, or burning
  • bladder pain
  • bloating or swelling of the face, arms, hands, lower legs, or feet
  • bloody or black, tarry stools
  • blurred vision
  • chills
  • clay-colored stools
  • cloudy urine
  • constipation
  • cough
  • dark-colored urine
  • diarrhea
  • difficult, burning, or painful urination
  • dizziness
  • fever
  • frequent urge to urinate
  • general feeling of discomfort or illness
  • general feeling of tiredness or weakness
  • headache
  • heartburn
  • indigestion
  • itching or rash
  • joint pain
  • light-colored stools
  • loss of appetite
  • lower back or side pain
  • muscle aches and pains
  • nausea
  • nervousness
  • pale skin
  • pounding in the ears
  • rapid weight gain
  • runny nose
  • severe stomach pain
  • shivering
  • slow or fast heartbeat
  • sore throat
  • stomach pain, continuing
  • sweating
  • tingling of the hands or feet
  • trouble sleeping
  • troubled breathing with exertion
  • unpleasant breath odor
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • unusual weight gain or loss
  • vomiting
  • vomiting of blood or material that looks like coffee grounds
  • yellow eyes or skin
Incidence not known:
  • Blistering, peeling, or loosening of the skin
  • change in consciousness
  • confusion as to time, place, or person
  • cracks in the skin
  • darkening of the skin
  • dry mouth
  • fainting
  • hallucinations
  • holding false beliefs that cannot be changed by fact
  • loss of consciousness
  • loss of heat from the body
  • mental depression
  • pain in lower back or side
  • pains in the chest, groin, or legs, especially calves of the legs
  • red skin lesions, often with a purple center
  • red, irritated eyes
  • red, swollen skin
  • scaly skin
  • seizures
  • severe headaches of sudden onset
  • sores, ulcers, or white spots in the mouth or on the lips
  • stiff neck or back
  • sudden loss of coordination
  • sudden onset of shortness of breath for no apparent reason
  • sudden onset of slurred speech
  • sudden vision changes
  • thirst
  • troubled breathing with exertion
  • unusual excitement, nervousness, or restlessness

Minor Side Effects

Some of the side effects that can occur with famotidine / ibuprofen may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

Less common:
  • Acid or sour stomach
  • back pain
  • belching
  • body aches or pain
  • cough producing mucus
  • difficulty having a bowel movement (stool)
  • difficulty with moving
  • ear congestion
  • loss of voice
  • muscle stiffness
  • pain or tenderness around the eyes and cheekbones
  • sneezing
  • stuffy nose

For Healthcare Professionals

Applies to famotidine / ibuprofen: oral tablet


The most frequently reported side effects included nausea, diarrhea, constipation, upper abdominal pain, and headache.[Ref]


Common (1% to 10%): Nausea, dyspepsia, diarrhea, constipation, upper abdominal pain, gastroesophageal reflux disease, vomiting, stomach discomfort, abdominal pain

Postmarketing reports: Nausea, diarrhea, vomiting, abdominal pain

Common (1% to 10%): Nausea, dyspepsia, diarrhea, constipation, upper abdominal pain, gastroesophageal reflux disease, vomiting, stomach discomfort, abdominal pain[Ref]


Common (1% to 10%): Hypertension

Postmarketing reports: Hypotension

Common (1% to 10%): Hypertension
Postmarketing reports: Myocardial infarction[Ref]


Common (1% to 10%): Serum creatinine increased
Frequency not reported: Acute renal failure

Common (1% to 10%): Serum creatinine increased
Postmarketing reports: Acute renal failure[Ref]


Common (1% to 10%): Anemia

Postmarketing reports: Anemia, thrombocytopenia, platelet count decreased, hemoglobin decreased

Common (1% to 10%): Anemia[Ref]


Postmarketing reports: Hepatic function abnormal, ALT increased, AST increased


Common (1% to 10%): Peripheral edema, influenza

Postmarketing reports: Pyrexia, condition aggravated, asthenia, drug ineffective, chest pain, fatigue, pain, peripheral edema, sepsis

Common (1% to 10%): Peripheral edema, influenza
Postmarketing reports: Pyrexia, pain, fatigue, asthenia, chest pain, drug ineffective[Ref]


Postmarketing reports: Appetite decreased[Ref]


Common (1% to 10%): Arthralgia, back pain

Common (1% to 10%): Arthralgia, back pain[Ref]

Nervous system

Common (1% to 10%): Headache

Postmarketing reports: Dizziness, headache

Common (1% to 10%): Headache
Postmarketing reports: Dizziness[Ref]


Common (1% to 10%): Upper respiratory tract infection, nasopharyngitis, sinusitis, bronchitis, cough, pharyngolaryngeal pain

Postmarketing reports: Pneumonia, dyspnea

Common (1% to 10%): Upper respiratory tract infection, nasopharyngitis, sinusitis, bronchitis, cough, pharyngolaryngeal pain
Postmarketing reports: Dyspnea[Ref]


Common (1% to 10%): Urinary tract infection

Common (1% to 10%): Urinary tract infection[Ref]


Postmarketing reports: Depression, anxiety[Ref]


1. "Product Information. Duexis (famotidine-ibuprofen)." Horizon Pharma USA Inc, Northbrook, IL.

Not all side effects for Duexis may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.