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Anakinra Side Effects

In Summary

Commonly reported side effects of anakinra include: infection, antibody development, and inflammation at injection site. Other side effects include: neutropenia. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to anakinra: subcutaneous solution

Along with its needed effects, anakinra may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking anakinra:

More common Less common or rare
  • Difficulty with swallowing
  • hives, itching, or rash
  • swelling of the face or lips
  • unusual bruising or bleeding
  • unusual tiredness or weakness
Incidence not known
  • Dizziness
  • fast heartbeat
  • hives or welts
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • puffiness or swelling of the eyelids or around the eyes, face, lips or tongue

Some side effects of anakinra may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Abdominal or stomach pain
  • bleeding, blistering, burning, coldness, discoloration of skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
  • difficulty with moving
  • headache
  • muscle aches or stiffness

For Healthcare Professionals

Applies to anakinra: subcutaneous solution

General

The most serious side effects have included infections and neutropenia, while the most common side effects have included injection site reactions.[Ref]

Local

Very common (10% or more): Injection site reaction (71%) (including erythema, ecchymosis, inflammation, and pain)[Ref]

Hematologic

Common (1% to 10%): Neutropenia, decreased total white blood cell count, decreased platelets
Frequency not reported: small increases in the eosinophil differential percentage[Ref]

Gastrointestinal

Very common (10% or more): Vomiting (14%)
Common (1% to 10%): Nausea, diarrhea, abdominal pain[Ref]

Respiratory

Very common (10% or more): Upper respiratory tract infection (19%), nasopharyngitis (11%)
Common (1% to 10%): Sinusitis, bronchitis[Ref]

Nervous system

Very common (10% or more): Headache (12%)[Ref]

Musculoskeletal

Common (1% to 10%): Arthralgia[Ref]

Genitourinary

Common (1% to 10%): Urinary tract infection[Ref]

Other

Very common (10% or more): Worsening of RA (19%), pyrexia (11%)[Ref]

Hepatic

Uncommon (0.1% to 1%): Hepatic enzyme increased
Frequency not reported: Non-infectious hepatitis, elevations of transaminases[Ref]

Hypersensitivity

Uncommon (0.1% to 1%): Allergic reactions (including anaphylactic reactions), angioedema, urticaria, pruritus
Frequency not reported: Rash[Ref]

Immunologic

Common (1% to 10%): Serious infections (primarily bacterial) (e.g., cellulitis, pneumonia, bone and joint infections), influenza-like symptoms
Frequency not reported: Development of immunogenicity[Ref]

Oncologic

Frequency not reported: Increased rate of lymphoma[Ref]

References

1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

2. Pharmaceutical Society of Australia "APPGuide online. Australian prescription products guide online. Available from: URL: http://www.appco.com.au/appguide/default.asp." ([2006]):

3. "Product Information. Kineret (anakinra)." Amgen, Thousand Oaks, CA.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

Medical Disclaimer

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