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Anakinra Dosage

Medically reviewed by Drugs.com. Last updated on Nov 15, 2022.

Applies to the following strengths: 100 mg/0.67 mL

Usual Adult Dose for Rheumatoid Arthritis

100 mg subcutaneously once a day

Comments:


Use: To reduce signs and symptoms and slow the progression of structural damage in moderately to severely active rheumatoid arthritis in patients who have failed 1 or more DMARDs

Usual Adult Dose for Cryopyrin-Associated Periodic Syndrome

Starting dose: 1 to 2 mg/kg subcutaneously per day
Dose adjustments: Doses should be adjusted in 0.5 to 1 mg/kg increments.
Maximum dose: 8 mg/kg/day

Comments:


Use: For the treatment of neonatal-onset multisystem inflammatory disease (NOMID)

Usual Adult Dose for Interleukin-1 Receptor Antagonist Deficiency

Starting dose: 1 to 2 mg/kg subcutaneously per day
Dose adjustments: Doses should be adjusted in 0.5 to 1 mg/kg increments.
Maximum dose: 8 mg/kg/day

Comments:


Use: For the treatment of deficiency of interleukin-1 receptor antagonist (DIRA)

Usual Adult Dose for COVID-19

For investigational use only

100 mg subcutaneously once a day for 10 days

Comments:


Use: For the treatment of COVID-19 in hospitalized patients with positive results of direct SARS-CoV-2 viral testing with pneumonia requiring supplemental oxygen (low- or high-flow oxygen) who are at risk of progressing to severe respiratory failure and likely to have an elevated plasma suPAR

Usual Pediatric Dose for Cryopyrin-Associated Periodic Syndrome

Starting dose: 1 to 2 mg/kg subcutaneously per day
Dose adjustments: Doses should be adjusted in 0.5 to 1 mg/kg increments.
Maximum dose: 8 mg/kg/day

Comments:


Use: For the treatment of NOMID

Usual Pediatric Dose for Interleukin-1 Receptor Antagonist Deficiency

Starting dose: 1 to 2 mg/kg subcutaneously per day
Dose adjustments: Doses should be adjusted in 0.5 to 1 mg/kg increments.
Maximum dose: 8 mg/kg/day

Comments:


Use: For the treatment of DIRA

Renal Dose Adjustments

Severe renal dysfunction or ESRD: Administration of the prescribed dose every other day should be considered.

EUA RECOMMENDATIONS FOR TREATMENT OF COVID-19 IN ADULTS:


Comments:

Liver Dose Adjustments

Data not available

Precautions

CONTRAINDICATIONS:


Safety and efficacy in the treatment of juvenile rheumatoid arthritis (JRA) have not been established in patients younger than 18 years; this drug is not recommended for pediatric use in JRA. This drug is not authorized/approved for emergency use in the treatment of COVID-19 in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

Severe renal dysfunction or ESRD: A dose schedule change should be considered.

Comments:

Other Comments

Administration advice:


Storage requirements:

Monitoring:

Patient advice:

Frequently asked questions

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.