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Anakinra Dosage

Medically reviewed by Drugs.com. Last updated on Apr 6, 2021.

Applies to the following strengths: 100 mg/0.67 mL

Usual Adult Dose for Rheumatoid Arthritis

100 mg subcutaneously once daily at approximately the same time each day

Comments:
-Alternating the injection site is recommended to avoid discomfort at the site of injection.

Use: To reduce symptoms and slow the progression of structural damage in moderately to severely active rheumatoid arthritis (RA) in patients who have failed 1 or more disease modifying antirheumatic drugs (DMARDs)

Usual Adult Dose for Interleukin-1 Receptor Antagonist Deficiency

Initial dose: 1 to 2 mg/kg subcutaneously daily
Dose escalation: Adjust doses in 0.5 to 1 mg/kg increments
Maximum dose: 8 mg/kg subcutaneously daily

Use: For the treatment of Deficiency of Interleukin-1 Receptor Antagonist (DIRA)

Usual Pediatric Dose for Cryopyrin-Associated Periodic Syndrome

Initial dose: 1 to 2 mg/kg subcutaneously daily
Dose escalation: Adjust doses in 0.5 to 1 mg/kg increments
Maximum dose: 8 mg/kg subcutaneously daily
NOTE: Once daily administration is generally recommended, but the dose may be split into twice daily administrations.

Comments:
-The therapeutic response is primarily reflected by reduction in symptoms such as fever, rash, joint pain, and headache, but also in inflammatory serum markers (CRP/SAA levels), or occurrence of flares.

Use: Cryopyrin-Associated Periodic Syndromes (CAPS): Treatment of Neonatal-Onset Multisystem Inflammatory Disease (NOMID)

Usual Pediatric Dose for Interleukin-1 Receptor Antagonist Deficiency

1 month and older:
Initial dose: 1 to 2 mg/kg subcutaneously daily
Dose escalation: Adjust doses in 0.5 to 1 mg/kg increments
Maximum dose: 8 mg/kg subcutaneously daily

Use: For the treatment of Deficiency of Interleukin-1 Receptor Antagonist (DIRA) in children 1 month and older

Renal Dose Adjustments

Severe renal impairment (CrCl less than 30 mL/min): Consider every other day dosing.

Liver Dose Adjustments

Data not available

Precautions

CONTRAINDICATIONS:
-Hypersensitivity to the active component or any of the ingredients
-Patients with known hypersensitivity to E coli-derived proteins

Consult WARNINGS section for additional precautions.

Dialysis

Less than 2.5% of the administered dose of this drug is removed by hemodialysis or continuous ambulatory peritoneal dialysis. A dose schedule change should be considered for severe renal insufficiency or end stage renal disease.

Other Comments

Administration advice:
-The dose should be administered at approximately the same time every day.
-Each syringe is intended for a single use; use a new syringe for each dose.
-Discard any unused portion after each dose.
-Once daily administration is generally recommended, but the dose may be split into twice daily administrations.
-Each syringe is intended for a single use. A new syringe must be used for each dose. Any unused portion after each dose should be discarded.

Storage requirements:
-This drug should be stored in the refrigerator at 2C to 8C (36F to 46F). Do not freeze. Do not shake. Protect from light.
-Unused portions in the syringe should be discarded because this drug does not contain a preservative.

Monitoring:
-Neutrophil counts should be obtained before beginning therapy, then once a month for 3 months, and thereafter on a quarterly basis.

Frequently asked questions

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.