Skip to Content

Anakinra Dosage

Applies to the following strength(s): 100 mg/0.67 mL

The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.

Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Rheumatoid Arthritis

100 mg subcutaneously once daily

Comments:
-The dose should be administered at approximately the same time every day.
-Alternating the injection site is recommended to avoid discomfort at the site of injection.

Use: Rheumatoid Arthritis (RA): To reduce symptoms and slow the progression of structural damage in moderately to severely active RA, in patients 18 years of age or older who have failed 1 or more disease modifying antirheumatic drugs (DMARDs)

Usual Adult Dose for Cryopyrin-Associated Periodic Syndrome

Initial dose: 1 to 2 mg/kg subcutaneously daily
Maximum dose: 8 mg/kg subcutaneously daily

Comments:
-Doses should be adjusted in 0.5 to 1.0 mg/kg increments.
-Once daily administration is generally recommended, but the dose may be split into twice daily administrations.
-Each syringe is intended for a single use. A new syringe must be used for each dose. Any unused portion after each dose should be discarded.
-The therapeutic response is primarily reflected by reduction in symptoms such as fever, rash, joint pain, and headache, but also in inflammatory serum markers (CRP/SAA levels), or occurrence of flares.

Use: Cryopyrin-Associated Periodic Syndromes (CAPS): Treatment of Neonatal-Onset Multisystem Inflammatory Disease (NOMID)

Usual Pediatric Dose for Cryopyrin-Associated Periodic Syndrome

Initial dose: 1 to 2 mg/kg subcutaneously daily
Maximum dose: 8 mg/kg subcutaneously daily

Comments:
-Doses should be adjusted 0.5 to 1.0 mg/kg increments.
-Once daily administration is generally recommended, but the dose may be split into twice daily administrations.
-Each syringe is intended for a single use. A new syringe must be used for each dose. Any unused portion after each dose should be discarded.
-The therapeutic response is primarily reflected by reduction in symptoms such as fever, rash, joint pain, and headache, but also in inflammatory serum markers (CRP/SAA levels), or occurrence of flares.

Use: Cryopyrin-Associated Periodic Syndromes (CAPS): Treatment of Neonatal-Onset Multisystem Inflammatory Disease (NOMID)

Renal Dose Adjustments

CrCl less than 30 mL/min: The mean plasma clearance is decreased 70% to 75%. Patients may have a higher risk of toxicity. There is insufficient information available to make a dosage recommendation.

Liver Dose Adjustments

Data not available

Precautions

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:
-The dose should be administered at the same time each day.

Storage requirements:
-Store under refrigeration and protect from light.
-Unused portions in the syringe should be discarded because this drug does not contain a preservative.

Monitoring:
-Neutrophil counts should be obtained before beginning treatment, then once a month for 3 months, thereafter on a quarterly basis.

Hide