Can you take antibiotics with Mavyret?
What antibiotics can you take when you have hepatitis?
When you are taking Mavyret and need to take antibiotics you need to check:
- if there is an interaction between the antibiotic and Mavyret
- if there is an interaction between the antibiotic and liver disease or liver dysfunction.
If the antibiotic does not have a drug interaction with Mavyret AND it does not have a liver disease or liver impairment interaction it should be safe to take (as long as your doctor has checked for interactions with any other medicine you take and other health issues you have).
Mavyret is used to treat hepatitis C which is a viral infection that mainly affects the liver. When you have hepatitis C over time it can cause the liver to become damaged and not function properly. Some medicines, including some antibiotics, can have a bad effect on your body if your liver is impaired or damaged. This is known as a drug disease interaction. When you have hepatitis, it is important before you take any medicines, that you check the new medicine will not cause problems due to your liver issues.
Table of Mavyret Antibiotic Interactions and Liver Disease Interactions
|
Antibiotic Group |
Antibiotic Generic Name |
Antibiotic Brand Name |
Mavyret Drug Interaction |
Liver Disease Interaction |
|
Penicillin class |
amoxicillin | Amoxil | No | No |
| amoxicillin and clavulanate | Augmentin, Augmentin ES-600, Augmentin XR | No |
Yes, hepatotoxicity. Major potential hazard, moderate plausibility. Applies to: liver disease. |
|
| ampicillin | Unasyn | No | No | |
| dicloxacillin | Dynapen | No | No | |
| oxacillin | Bactocill | No | No | |
| penicillin V potassium | PC Pen VK | No | No | |
| Tetracyclines | demeclocycline | Declomycin | No |
Yes, hepatotoxicity. Moderate potential hazard, moderate plausibility. Applies to: liver disease. |
| doxycycline | Adoxa, Doryx, Doxy 100, Oracea, Vibramycin | No |
Yes, hepatotoxicity. moderate potential hazard, high plausibility. Applies to: liver disease, biliary obstruction. |
|
| eravacycline | Xerava | No | No | |
| minocycline | Dynacin, Minocin, Solodyn | No |
Yes, hepatotoxicity. Moderate potential hazard, high plausibility. Applies to: liver disease. |
|
| omadacycline | Nuzyra | No | No | |
| tetracycline | Panmycin, Sumycin | No |
Yes, hepatotoxicity. Moderate potential hazard, moderate plausibility. Applies to: liver disease. |
|
| Cephalosporins | cefaclor | Ceclor (brand discontinued) | No |
Yes, liver disease. Moderate potential hazard, moderate plausibility |
| cefdinir | Omnicef (discontinued) | No |
Yes, liver disease. Moderate potential hazard, moderate plausibility |
|
| cefotaxime | Claforan | No |
Yes, Liver disease. Moderate potential hazard, moderate plausibility. |
|
| ceftazidime | Avycaz, Fortaz, Tazicef | No |
Yes, liver disease. Moderate potential hazard, moderate plausibility |
|
| ceftriaxone | Rocephin (discontinued) | No |
Yes, liver disease. Moderate potential hazard, Moderate plausibility. |
|
| cefuroxime | Zinacef | No |
Yes, liver disease. Moderate potential hazard, Moderate plausibility. |
|
| cephlexin | Keflex | No |
Yes, Liver disease. Moderate potential hazard, moderate plausibility. |
|
| Quinolones | ciprofloxacin | Cipro, Cipro XR | No | No |
| levofloxacin | Levaquin | No | No | |
| moxifloxacin | Avelox | No |
Yes, liver disease. Major potential hazard, moderate plausibility |
|
| Lincomycins | clindamycin | Cleocin, Cleocin T, Evoclin | No |
Yes, liver disease. Moderate potential hazard, high plausibility. |
| lincomycin | Lincocin | No |
Yes, liver disease. Moderate potential hazard, high plausibility. |
|
| Macrolides | azithromycin | Zithromax | No |
Yes, liver disease. Moderate potential hazard, moderate plausibility. |
| clarithromycin | Biaxin | No | No | |
| erythromycin | E.E.S., Ery-Tab, Eryc | No |
Yes, liver disease. Major potential hazard, moderate plausibility. Applies to: liver disease, biliary obstruction |
|
| Sulfonamides | sulfamethoxazole and trimethoprim | Bactrim, Bactrim DS, Septra | No |
Yes, liver disease. Major potential hazard, Moderate plausibility. |
| sulfasalazine | Azulfidine | No |
Yes, liver disease. Major potential hazard, Moderate plausibility. |
|
| Glycopeptide Antibiotics | oritavancin | Orbactiv | Yes, Moderate interaction |
Yes, hepatic impairment Moderate potential hazard, moderate plausibility. |
| vancomycin | Firvanq, Vancocin | No | No | |
| Aminoglycosides | gentamicin | Garamycin (discontinued), Genoptic | No | No |
| tobramycin | TOBI, Tobradex, Tobrex | No | No | |
| amikacin | Amikin | No | No | |
| Carbapenems | imipenem and cilastatin | Primaxin | No | No |
| meropenem | Merrem | No | No | |
| ertapenem | Invanz | No | No | |
|
Antibiotic Generic Name |
Antibiotic Brand Name |
Mavyret Drug Interaction |
Liver Disease Interaction |
Bottom LIne:
An antibiotic should NOT be taken with Mavyret if
- the antibiotic has a drug interaction with Mavyret, or
- the antibiotic has an interaction with liver disease or liver dysfunction.
Your Doctor or health professional should check for drug-drug interactions, drug-disease interactions, and be aware of any other health conditions and medicines you are on before prescribing you any medication.
Related questions
References
- Mavyret Drug and Disease Interaction https://www.drugs.com/drug-interactions/glecaprevir-pibrentasvir,mavyret.html
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