How long is Mavyret treatment?

Treatment with Mavyret can range from 8 to 16 weeks depending upon your liver function, previous treatments, and other medical conditions you may have. Your doctor will decide the most appropriate length of time for your treatment regimen.

Mavyret (glecaprevir and pibrentasvir) is an oral prescription medicine used to treat:

• adults and children 3 years of age and older with recently infected (acute) or long-lasting (chronic) hepatitis C virus (HCV) genotypes 1, 2, 3, 4, 5 or 6 infection without cirrhosis or with compensated cirrhosis. Compensated cirrhosis occurs in early stage HCV when the liver is still functioning and the person may have few or no symptoms of liver disease.
• HCV genotype 1 infection in adults and children 3 years of age and older who have been previously treated with a medicine regimen that contained an HCV NS5A inhibitor or an NS3/4A protease inhibitor (PI), but not both.

These regimens are appropriate for patients with either HCV infection alone or patients with both HCV and HIV infection. Cure rates of up to 95% to 99% after 8 weeks of treatment have been reported in people with HCV who took Mavyret.

Is Mavyret given as an injection or by mouth?

Mavyret is given by mouth as either an oral tablet or as oral pellets. The tablets are a fixed dose drug combination that contains glecaprevir 100 mg and pibrentasvir 40 mg in each tablet. The oral pellets contain glecaprevir 50 mg and pibrentasvir 20 mg in each packet.

The oral pellets are recommended for children 3 years old to less than 12 years old OR weighing less than 45 kg. Dosing is based on weight.

Treatment-naïve patients

For patients who have not received HCV treatment for the current infection (treatment-naïve), the recommended length of treatment for HCV genotypes 1 through 6 is eight (8) weeks (in patients with either no cirrhosis; or compensated cirrhosis, meaning you have no symptoms of liver disease).

Treatment-experienced patients

For patients who have previously received HCV treatment for the current infection, the duration of treatment can range from 8 to 16 weeks depending upon your HCV genotype, previous treatment regimen, your liver function and / or the presence of cirrhosis.

Related questions

• What is the difference between hepatitis B and C?
• What are the new drugs for the treatment of hepatitis C?
• How much does Mavyret cost?

Liver or kidney transplant recipients

Mavyret is recommended for 12 weeks in adults and children 3 years and older who are liver or kidney transplant recipients.

A 16-week treatment duration is recommended in HCV genotype 1 patients who are NS5A inhibitor-experienced without prior treatment with an NS3/4A protease inhibitor; or in genotype 3-infected patients who are PRS treatment-experienced. PRS means that the patient has had prior treatment experience with regimens containing (peg) interferon, ribavirin and/or sofosbuvir, but no prior treatment experience with an HCV NS3/4A PI or NS5A inhibitor.

What is the Mavyret dose for adults and children?

Adult dose:

• The recommended oral dosage of Mavyret is ​3 tablets ​taken at the same time once daily with food.
• The total daily dose equals glecaprevir 300 mg and pibrentasvir 120 mg.

Dose in children 12 years of age and older, OR who weigh at least 45 kg:

• The recommended oral dosage of Mavyret is ​3 tablets ​taken at the same time once daily with food.
• The total daily dose equals glecaprevir 300 mg and pibrentasvir 120 mg.

Dose in children 3 years to less than 12 years old:

• The dose in children 3 years to less than 12 years old is based on weight. See the weight-based dosing recommendations here. If you questions about your child's dose, ask your healthcare provider.
• Follow the instructions for preparation and use of the Mavyret oral pellets. If you are not sure how to prepare the pellets, ask your healthcare provider or pharmacist to show you how to use it.

Take your Mavyret exactly as prescribed by your doctor. If you have a history of liver disease, be sure to tell your health care provider.

Read More: How long does Mavyret stay in your system?

This is not all the information you need to know about Mavyret (glecaprevir and pibrentasvir) for safe and effective use and does not take the place of your dcotor's directions. Review the full product information and discuss this information and any questions you have with your doctor or other health care provider.

Read next

See also:

Related medical questions

• Why take Mavyret with food?
• Can you take ibuprofen with Mavyret?
• How long does Mavyret stay in your system?
• Does Mavyret make you feel sick?
• Can you take Mavyret while pregnant?
• Does Mavyret cure hep C (HCV)? What is the success rate?
• Can you take antibiotics with Mavyret?
• Does Mavyret cause itching?
• What types of Hepatitis C does Mavyret treat?

Drug information

• Mavyret Information for Consumers
• Mavyret prescribing info & package insert (for Health Professionals)
• Side Effects of Mavyret (detailed)
• Mavyret user reviews (428)

Related support groups

• Mavyret (25 questions, 48 members)
• Hepatitis C (53 questions, 693 members)
• Liver Cirrhosis (18 questions, 207 members)

Medical Disclaimer