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Learn about Mavyret, a treatment for Hepatitis C

Glecaprevir and pibrentasvir

Generic Name: glecaprevir and pibrentasvir (glec A pre vir and pi BRENT as vir)
Brand Name: Mavyret

Medically reviewed on August 14, 2018

What is glecaprevir and pibrentasvir?

See also: Mavyret

Glecaprevir and pibrentasvir are antiviral medications that prevent hepatitis C virus (HCV) from multiplying in your body.

Glecaprevir and pibrentasvir is a combination medicine used to treat chronic hepatitis C in adults with HCV genotype 1, 2, 3, 4, 5, or 6.

Glecaprevir and pibrentasvir is sometimes given after other medicines have been tried without success.

Glecaprevir and pibrentasvir may also be used for purposes not listed in this medication guide.

Important Information

You should not use glecaprevir and pibrentasvir if you have severe liver disease, or if you also take atazanavir or rifampin.

If you have ever had hepatitis B, glecaprevir and pibrentasvir can cause this virus to come back or get worse. Your doctor will perform blood tests to make sure you do not have hepatitis B.

Before taking this medicine

You should not use this medicine if you are allergic to glecaprevir or pibrentasvir, or if:

  • you have severe liver disease; or

  • you also take atazanavir or rifampin.

Tell your doctor if you have ever had:

  • hepatitis B;

  • liver problems other than hepatitis;

  • a liver or kidney transplant; or

  • HIV (human immunodeficiency virus).

It is not known whether glecaprevir and pibrentasvir will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

It may not be safe to breast-feed while using this medicine. Ask your doctor about any risk.

How should I take glecaprevir and pibrentasvir?

Your doctor will perform blood tests to make sure you do not have conditions that would prevent you from safely using glecaprevir and pibrentasvir.

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Glecaprevir and pibrentasvir is usually taken as 3 tablets once per day for 8 to 16 weeks.

Take with food.

You will need frequent blood tests to check your liver function.

You should not stop using glecaprevir and pibrentasvir suddenly. Stopping suddenly could make your condition harder to treat with hepatitis C antiviral medicine.

Use all hepatitis C medications as directed and read all medication guides you receive. Do not change your dose or dosing schedule without your doctor's advice. Every person with hepatitis C should remain under the care of a doctor.

If you've ever had hepatitis B, using glecaprevir and pibrentasvir can cause this virus to become active or get worse. You may need frequent liver function tests while using glecaprevir and pibrentasvir and for several months after you stop.

Store this medicine in the original container at room temperature away from moisture and heat. Keep each tablet in the foil blister pack until you are ready to take it.

What happens if I miss a dose?

Use the medicine as soon as you can, but skip the missed dose if you are more than 18 hours late for the dose. Do not use two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking glecaprevir and pibrentasvir?

Using glecaprevir and pibrentasvir will not prevent your disease from spreading. Do not have unprotected sex or share razors or toothbrushes. Talk with your doctor about safe ways to prevent HCV transmission during sex. Sharing drug or medicine needles is never safe, even for a healthy person.

Glecaprevir and pibrentasvir side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • slow heartbeats;

  • weak or shallow breathing; or

  • low red blood cells--pale skin, weakness, rapid heart rate, trouble concentrating.

Common side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

What other drugs will affect glecaprevir and pibrentasvir?

Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

Other drugs can affect glecaprevir and pibrentasvir, and some drugs should not be used at the same time. Tell your doctor about all your current medicines and any medicine you start or stop using. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.