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Glecaprevir / Pibrentasvir Dosage

Medically reviewed by Drugs.com. Last updated on Feb 13, 2024.

Applies to the following strengths: 50 mg-20 mg; 100 mg-40 mg

Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Chronic Hepatitis C

Glecaprevir 300 mg-pibrentasvir 120 mg (3 tablets) orally once a day

Duration of Therapy:
THERAPY-NAIVE PATIENTS:
HCV genotype 1, 2, 3, 4, 5, or 6:


THERAPY-EXPERIENCED PATIENTS:
HCV genotype 1 (prior therapy with regimen containing an NS5A inhibitor without prior therapy with an NS3/4A protease inhibitor):

HCV genotype 1 (prior therapy with regimen containing an NS3/4A protease inhibitor without prior therapy with an NS5A inhibitor):

HCV genotype 1, 2, 4, 5, or 6 (prior therapy with regimen containing PRS):

HCV genotype 3 (prior therapy with regimen containing PRS):

LIVER OR KIDNEY TRANSPLANT RECIPIENTS: 12 weeks

Comments:

Uses:

Usual Pediatric Dose for Chronic Hepatitis C

3 to less than 12 years:


12 years or older: Glecaprevir 300 mg-pibrentasvir 120 mg (3 tablets) orally once a day

Duration of Therapy:
THERAPY-NAIVE PATIENTS:
HCV genotype 1, 2, 3, 4, 5, or 6:

THERAPY-EXPERIENCED PATIENTS:
HCV genotype 1 (prior therapy with regimen containing an NS5A inhibitor without prior therapy with an NS3/4A protease inhibitor):

HCV genotype 1 (prior therapy with regimen containing an NS3/4A protease inhibitor without prior therapy with an NS5A inhibitor):

HCV genotype 1, 2, 4, 5, or 6 (prior therapy with regimen containing PRS):

HCV genotype 3 (prior therapy with regimen containing PRS):

LIVER OR KIDNEY TRANSPLANT RECIPIENTS: 12 weeks

Comments:

Uses:

Renal Dose Adjustments

Mild, moderate, or severe renal dysfunction: No adjustment recommended.

Liver Dose Adjustments

Mild liver dysfunction (Child-Pugh A): No adjustment recommended.
Moderate or severe liver dysfunction (Child-Pugh B or C) or any history of hepatic decompensation: Contraindicated

Comments:

Precautions

US BOXED WARNING:


CONTRAINDICATIONS:

Safety and efficacy have not been established in patients younger than 3 years.

Consult WARNINGS section for additional precautions.

Dialysis

No adjustment recommended.

Other Comments

Administration advice:


Storage requirements:

Reconstitution/preparation techniques:

General:

Monitoring:

Patient advice:

Frequently asked questions

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.