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User Reviews for Epclusa

Epclusa has an average rating of 7.7 out of 10 from a total of 334 ratings on Drugs.com. 67% of reviewers reported a positive experience, while 13% reported a negative experience.

Condition Avg. Rating Reviews Compare
Hepatitis C  
7.7
334 reviews 25 medications

Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published.

Reviews for Epclusa

Grant Casteel · Taken for 1 to 6 months · June 14, 2021

For Hepatitis C "Wanted to take this time and let everyone know about my experience. I started taking my Epclusa March 22, 2021. Just finished my last dose tonight June 13. I did not miss a day of work and worked out five days a week during the entire treatment. I have been virus free since my first test at week four and have continued virus free throughout. Will have my SVR test sometime in September. For those of you that are concerned about starting treatment,I found it to be a breeze and I am sure you will too! Thankful for this treatment as I am at stage 2/3 fibrosis and hopefully I will regress to a lower stage if not completely.Good luck to everyone getting ready to start you much God bless!"

10 / 10
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Stormy · Taken for 1 to 6 months · January 19, 2021

For Hepatitis C "I have 5 days left of Epclusa. The first two months I experienced some headaches and tiredness. This 3rd month is really taking a toll on me though. The headaches are worse and I have no energy. I’ve felt too weak to even go to work for the past week. The worst part is I feel like I’m losing my mind. I don’t know if it’s depression or anxiety or what, but it’s definitely it very difficult to function in a normal, healthy way."

7 / 10
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Hay93 · Taken for 1 to 6 months · July 4, 2021

For Hepatitis C "I have finished my first bottle of Epclusa, and am now on week 5 of treatment. So far I’ve had no side effects that I have noticed , because I already had headaches and diarrhea before treatment , I had to stop taking my heartburn medication because of the drug interaction. I will get my first round of blood work this coming week and am very hopeful this medication has worked for me , it has honestly made me feel better about myself as a person , I am 3 years sober of IV Meth use and this was the one thing from my past I was still dragging around … hepatitis. I feel once this is over with I will have completely gained my life back ."

10 / 10
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Frequently asked questions

AW · Taken for 1 to 6 months · April 11, 2021

For Hepatitis C "Think about it people! How many of you received this medicine free or better yet my company insurance paid 80 percent of $72,000.00. Guess where the other came from, a coupon that Epclusa provided. Ever heard of that before? It's been 15 months since I finished my last pill. My stomach looks as if I have cirrhosis, it feels like I have an infection in my stomach, I'm like the other lady states about hormonal issues I'm 65 and started having acne, I'm extremely depressed, I've developed major arthritic symptoms, this drug has cured the hep C but my day to day journey is horrific. I do not recommend this drug. Your doctor will tell you there are no side effects. How do they really know. I'll never listen to any doctor again. When any medication has only been around for a short period, don't label it as no side effects. Hope you doctor's and drug manufacturers can sleep good at night because you won't!"

1 / 10
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Rodney · Taken for 1 to 6 months · October 30, 2019

For Hepatitis C "I just want people to know that when the Epclusa is killing the hep c virus in your body your probably going to feel a little nausea. The virus is multiplying millions of times in your body - there's war between the epclusa and the hep c just hang in there you'll be glad when the 12 weeks are over god bless"

10 / 10
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Sheldoor · February 12, 2021

For Hepatitis C "Started Epclusa 2019 March for Hep C type 2b. I ate small items/meals throughout the day. Stayed hydrated + no caffeine of any sort. Took pill at 6 am with a piece of bread... was on extreme health regime while taking it. Nothing terrible. But after treatment was over, caffeine of any sort gives me a 3 day migraine. I am more sensitive to all chemicals in food and drink + get headaches easily, including fructose and sugar (small amounts)... by the way, I only got headaches before Epclusa when trying to get off coffee due to caffeine withdrawal. My adrenals and emotions seem to go from 1 to 10 very quickly. Although I am happy that Epclusa cured my hep C, it also has changed my life a lot. It is now Jan 2021, and I still experience these symptoms. I am very afraid to get the Covid-19 vaccination due to the headache side effect. Afraid my head may EXPLODE. hope this helps somebody..."

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Teri · Taken for 1 to 6 months · June 6, 2022

For Hepatitis C "I've not been the same since taking this horrible drug. I asked about the side-effects before deciding to take it and was told only temporary headache, nausea etc. What they did not mention was the permanent irritability and/or depression. No good feeling ever. It's been almost 3 years. I did not take the 3rd month as these effects were too severe. Did it cure my new Hep C? I don't know and frankly don't care. Please be wary of new drugs and try to find ALL the 'post-market side effects'"

1 / 10
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More FAQ

Blange 20 · Taken for 1 to 6 months · September 6, 2019

For Hepatitis C "Well on my first review 2019-07-28 I said I'd come back after a bit. Now I am just over half way through my treatment. I get what you all say about tinnitus. Also when I wake up in morning I'm the same with feeling rough. But once I've had a coffee it dies down. My feet have been aching a bit as has my back, but I've had no sickness or headaches. I think that if you have a life threatening disease like hep c which is never going away then it's like carrying bad luggage around everyday. If you get a chance to get rid of it and there is a few side effects that are quite manageable then it's got to be worth it. I felt ok apart from brain fog at first, but it's got a bit worse as I've gone on with meds. But I am more than willing to suffer these for 12wks than stay sick forever. I hope you all have as best time on epclusa that you all can and become hep c free. Take care people"

8 / 10
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Grandpa DD · Taken for 1 to 6 months · November 9, 2020

For Hepatitis C "I was a Intravenous drug user from age 19 to 32 years old. Clean from all drugs from February 1 1988 to present. I have had hepatitis from age 19 to 65 years old and 6 weeks on epclusa with non detectable test I had hep C geno type 1A. So grateful for Epclusa. It has allowed me to live longer than expected and 6 more weeks until treatment is completed. Very mild side affects ( headache, mood swings and lite depression) so far. At the age of 45 to 50 I did interferon/ribavarin 3 separate times and never was able to finish due to terrible side affects. EPCLUSA will and is going to save my life. Thanks to everyone that made this happen."

9 / 10
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Rodney · Taken for 1 to 6 months · December 20, 2019

For Hepatitis C "My name is Rodney I live in southeast Missouri I'm beginning my 3rd month on Epclusa just went in to get my blood results my Hep c. Virus is gone still got one more month of treatment I've had zero side effects this medicine is a life saver"

10 / 10
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JeffM · Taken for 1 to 6 months · April 23, 2021

For Hepatitis C "I just finished my 12th and final week of taking Epclusa one week ago. I probably got Hep C in the Army during the early 1970's. I am now 68 years old. These are the side effects that I noticed - Brain Fog. Just not able to think clearly and rationally. Insomnia. I had to get medication to sleep. My normal libido was gone soon after starting Epclusa. I have had no sex with my wife or even the slightest desire to have sex. I will not know if the Epclusa got rid of the Hep C for another 3 weeks when I have the first Blood Test. Currently I am just wondering if I will ever feel normal again. I still feel like I am on the Epclusa. Talking to my doctor is a waste of time. She does not believe that Epclusa caused any of the problems that I am having."

5 / 10
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Andy · Taken for 1 to 6 months · August 16, 2020

For Hepatitis C "I was diagnosed Hep C 1 , and prescribed Epculsa, from the very first tablet I felt something working inside , within one month my count was down from millions to low numbers, the course was completed , I am now Hep C free. No side effects what so ever , thank you Gilliad & The NHS....!!!!!"

10 / 10
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jjjj456 · Taken for 1 to 6 months · January 25, 2022

For Hepatitis C "It is 1/25/2022 and I took Epclusa in October 2018 for the full 12 weeks. I wanted to come back and share an update. During the treatment I was tired a lot but slept great. It was very shortly (within a month) after I completed treatment where I started to feel terrible. My body was breaking down and I developed Tinnitus that is still here to this day which is a very annoying condition. I do wish that I never did the treatment, I felt better before treatment but the doctor "sold" me this medicine. I did see a Naturopathic doctor that ran several tests that regular doctors do not do. I was severely deficient in many nutrients that was contributing to my body breaking down. I supplemented with what I was deficient in, acupuncture, cryotherapy, exercises, and red light therapy. I slowly got much better with replenishing what the Epclusa drained from my body. I don't think my Tinnitus will ever go away but at least I don't feel like my body is breaking down now. I still regret taking this."

2 / 10
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The cat · November 10, 2019

For Hepatitis C "I am Genotype 1a, 59 years old, male, active and otherwise healthy. I was diagnosed in 1995 but have not really suffered any ill affects of the virus other than mild liver enzyme imbalance. All of my fibroscans over the years have shown only minimal scarring. My doctor says Epcluza is a “perfect fit” for my situation so....I’m just starting my fifth week of treatment....no missed doses. As for side-affects I’m putting “extreme fatigue “ at the very top of my list. Nausea, headache and diarrhea come and go a bit but the fatigue and achy joints is up there. But...it is absolutely the right choice no matter the annoyance of these temporary yet fruitful ill effects. I say hang in there and enjoy the added years to your life. Love to all"

10 / 10
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Ash · Taken for 1 to 6 months · February 11, 2020

For Hepatitis C "I gave blood and found out I was Hep C positive! Been on Epclusa for 2 months and didn’t have any side effects until month 2 when I started itching all over and noticed some random big bruises on my legs! Call doc and they ran test and found my test for hep c is negative all thanks to this medicine! Only one more month! Stay strong y’all!!!!"

10 / 10
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Anonymous · Taken for 1 to 6 months · June 18, 2019

For Hepatitis C "The first 3 weeks of using Epclusa was insane...I was incredibly tired & nauseous. Like a mix of morning sickness and the worst hangover of your life. I used the comfort meds for the entire 90 day ordeal. However, now 3 months after my treatment I am still hep free, and am living a normal healthy life. I have no lingering side effects. Mentally, it was refreshing...like the last trace of damage I had done while being in active addiction had been erased.. Like I now have a clean slate. It has been an incredible gift, despite the 90 days of wanting to throw up. I would 100% do it again. It was worth it."

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Emmyy · July 29, 2022

For Hepatitis C "Hey I started taking this drug Epclusa in June 2022 diagnosed & started this drug. 2 weeks in blood test show negative, great, but noticed straight away I had a weird heart beat on taking it, a high blood pressure feeling. Also feeling sick gradually went off food lost my appetite, so lost weight. By the way I’m half way thru and I still have no appetite I’m still loosing weight. I get severe headaches and sickness so feel like I’m loosing my mind. Also aches, pains, joint pain, head pain ,back pain, sore throat. I feel like absolute rubbish. I can not understand the weight loss I’ve been reading thru these and not once seen weight loss am I the only one ? Anyway point is I feel like I’m dying"

5 / 10
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Jackie456 · Taken for 1 to 6 months · March 25, 2021

For Hepatitis C "I would not recommend this drug at all, I was fine before I took it, its been 2 years and I am getting worse. First got a rash on my head, when I started taking it, yeast infections for months, 5 months later the rash started on my feet, they were on fire, now the rash is all over my legs, looks like I was beat up, the side effects are not worth it at all, I don't trust doctors and this drug needs to be stopped! I know what big pharma are all about, money, After researching I am hoping I get to use better medicine to reverse the damage done!"

1 / 10
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Mary · Taken for 1 to 6 months · December 15, 2021

For Hepatitis C "I thought my 12-week treatment on Epclusa was going really hard on me. Apparently I had had Hep C in my body with no symptoms for 45 years from a blood transfusion. Was tested for it in routine tests and then had a liver biopsy, which showed only level one liver damage. I had during treatment and still suffer from extreme fatigue, memory issues, and insomnia. If I had ever dreamed how my life would change for the worse, I would never have taken the first pill! The only positive is that I am now free of Hep C, which I had apparently had for 45 years without symptoms. I am 79 years old and believe I could have lived the remaining years of my life without Epclusa!"

3 / 10
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A · January 13, 2021

For Hepatitis C "On my 2nd month with about 7 pills left. 3rd month was denied but I had to reach out to Gilead I think it was and they gave me a coupon. Instead of the $3,700 which I could not pay it will be 5 bucks for me thank goodness it worked out. 27 years old had hep c for about roughly 6 to 7 years. Was just test 3 days ago viral load is undetectable. My side effects Extremely tired so so so so tired Terrible headaches Random weird sores Ringing in ears Random neck pain Pain in lower back Extreme hunger in the am mixed with extreme sickness Some diarrhea Mood swings Irritability BRAIN FOG AND CONFUSION IS THE WORST itchiness I'm getting it all ways but in the end it's worth it. Also I get up at 2am everyday and work about a 10hr to 11hr shift of work and come home to my baby after and do not get to bed till 8 or 9 so I understand that is a lot on my body while fighting this also. Anyways hopefully this helps someone stay strong and keep fighting!!"

7 / 10
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GratefulSeniorCitize · Taken for 1 to 6 months · March 3, 2019

For Hepatitis C "I just received the results from my final blood test, which is given 3 months after you finish EPCLUSA. The virus is gone, and I am cured of Hepatitis C! This medicine has given me my retirement back, and I am so grateful and blessed. Stick with it everyone, it's worth it!"

10 / 10
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Skpp930 · June 5, 2019

For Hepatitis C "I pray for all of you that the symptoms you feel go away. All of mine have stayed with me since 2017 I am damaged inside my body inside my brain and all of these doctors all say the same thing - there's no way at Epclusa could have done this I hope all of you get through this and your symptoms to go away but mine stayed with me and I feel like I'm going crazy everyday. Everyday I feel more alive in my dreams than I do when I'm awake now I have constant pain in my knees, constant brain fog, everything hurts, I have no digestion, I have no colon that works anymore, it has messed everything up inside of me. It did get rid of hep C but in my opinion it messed me up. I would not tell anybody to take this medication this medication is the same thing as Harvoni with just a extra medicine and in it I pray for all of you taking this medicine. If my hep C comes back I will never try treatment again"

1 / 10
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KellyAnne1 · Taken for 1 to 6 months · November 23, 2016

For Hepatitis C "I am on week 8 of a 12 week regime of Epclusa. The first couple of days I did have a slight headache, but since then I haven't had any side effects. I had blood work done at week 5. I was already undetectable! Thanks to a Epclusa coupon my copay is $5! Other side effects include: the whites of my eyes are white again! I have energy like I haven't had in 20 years. My skin is younger looking. I sleep like a baby. The slight depression that I used to feel from being so tired all the time is gone. I can get out of bed so easily now and feel energized throughout the entire day. It is hard to go to sleep sometimes because I still have so much energy. I am so thankful for this medication. This has given me quality of life again.Thank you Gilead!"

10 / 10
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Fran · Taken for 1 to 6 months · September 11, 2019

For Hepatitis C "I’m on my 34th day of taking Epclusa, a little over 4 weeks, I thought I was going to be sick on my first two weeks, but I wasn’t just some tiredness and headaches off and on. Please,don’t worry about Epclusa, for me it’s been awesome, I wish I had done this forty years ago."

10 / 10
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Angeltn · Taken for 1 to 6 months · August 12, 2019

For Hepatitis C "Take my last dose of Epclusa in the morning. I have to say the last week, I felt really tired but if I had to do it all over again, I would. I will be going to my doctor in two weeks and I will let everyone know the results. Before Epclusa I was a very sick person, in and out of the hospital every month. Since I started this med I have feel better, and not been in the hospital . I feel much better, dont hesitate in taking this medicine. Drink plenty of water and take a daily walk. I wish I had done this before my liver had been damaged. Happy with treatment."

9 / 10
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This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.