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Epclusa User Reviews & Ratings (Page 5)

Epclusa has an average rating of 7.6 out of 10 from a total of 407 reviews on Drugs.com. 61% of reviewers reported a positive experience, while 12% reported a negative experience.

Reviews for Epclusa

Commonly mentioned side effects
  • Jac...
  • July 25, 2018

For Hepatitis C "My husband is on day 55 of Epclusa. He has done fantastic so far! Levels have lowered, soon hopefully gone, and he has had minimal issues and no serious issues that have prevented him from working (he does concrete and physical labor in 100+ degrees daily). He has had some headaches, and the further on he goes, the worse his bone and joint pain gets, but again, not debilitating. He looks at the brighter side daily, and having a positive attitude is the key to tolerating the aches and pains that come along. He has had dizzy spells, so we increase his water intake, and it makes it better. No other medications were tried prior to this, so I can't speak for them, but I can say that Epclusa has definitely been a liver saver! It also takes a lot for your significant other to be a part of this, speaking personally, and dealing with the irritability and mood changes... but I also look at the brighter side and stay optimistic. A good attitude is needed for all involved!"

10 / 10
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  • Anonymous
  • February 2, 2019

For Hepatitis C "Have used Epclusa 400 mg/100 mg tablet for 12 weeks. Just finished in July 2018, and the test result was HCV negative. Now after 6 months, in January 2019, in re-investigation, again the HCV is positive."

1 / 10
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  • Tru...
  • Taken for 1 to 6 months
  • November 17, 2022

For Hepatitis C "Lipase levels raised 11 months after completion of Epclusa, creatinine levels high, triglycerides high, and LDL high. Thrombocytopenia developed. Severe abdominal issues after completion of this medication, so I don’t think at this point the benefits of using Epclusa were worth the long-lasting side effects. I never had any issues during 25 years of HCV until I took the Epclusa."

1 / 10
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Frequently asked questions

  • KQT...
  • July 20, 2017

For Hepatitis C "I have 10 days left on my Epclusa treatment! Before I started treatment, my viral load was 5,740,000. After 4 weeks of treatment, it was down to 79! My liver enzymes are normal now. I struggled for about a week (week 9) with stomach problems, headaches, and joint pain. I had stated previously I was Genotype 2 (B) and was diagnosed in 2005. Had 2 healthy kids, and I am looking forward to kicking Hep C and my stage 2 fibrosis. I have a new lease on life, and I have a good feeling about curing this virus and watching my kids grow up. Stay positive, eat right, and drink your water!"

10 / 10
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  • Tay...
  • Taken for 1 to 6 months
  • November 7, 2019

For Hepatitis C "I am on month two. It has been very rough. A lot of nausea, diarrhea, night sweats, flu-like symptoms, insomnia, chest pain, blisters on the inside of my mouth, itchy skin, hot flashes... it hasn't gotten any better. I am forever grateful though. I am diagnosed with genotype 3A. I am still in F1 but almost F2 (mild scarring). I was denied treatment for 4 years or so, and they finally approved me. I don't care what I go through now, as long as I am hep C free. My last labs are almost clear of hep C. Keep fighting!!!"

10 / 10
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  • Xju...
  • Taken for less than 1 month
  • July 11, 2018

For Hepatitis C "I have hep C genotype 2b, viral load over 10 million. I started Epclusa 4 days ago. I was really excited, as for the first two days I had absolutely no side effects. Now, relentless overproduction of stomach acid. My stomach is on fire, and I feel like I want to throw up all the time. I pray this goes away. I was an IV drug user for over 20 years and an alcoholic. I walked away from both of those deadly habits. Now I just want to get rid of this horrible virus."

10 / 10
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  • Tan...
  • Taken for less than 1 month
  • April 15, 2021

For Hepatitis C "I found out in December 2020 that I have hep C - I know I had to have gotten it within the past 3 to 4 years! I just started taking Epclusa yesterday on 4/13/21. I decided to start taking it in the middle of the afternoon in case the side effects were bad. Last night, about 8 or 9 hours after taking it, I started feeling pain on the inside of my ankle joints and felt my feet start feeling tingly - it would be okay while walking around, but the moment I sat or laid down, I started feeling it. It helped to elevate my feet. I didn't have that feeling this morning, but a few hours after taking it, the feeling started happening again and this time I am also getting the pain in my left elbow joint. I hope and pray that it doesn't get worse, but I am expecting to feel worse before I feel better! I hope and pray everyone with hep C can get through treatment, be cured, and never get it again! I will update again if side effects worsen."

10 / 10
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More FAQ

  • Hop...
  • Taken for less than 1 month
  • April 27, 2019

For Hepatitis C "I am on day 24 of taking Epclusa and so far just some headaches and brain fogginess, staying positive and nervous for the end result. Almost seems too good to be true to be cured from Hep C after 19 years with it. I have a 2-year-old to raise, so I really need it to work. My liver hurts every once in a while, but trying not to overanalyze if the medicine is working by my body aches. Lol."

9 / 10
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  • Cen...
  • Taken for 1 to 6 months
  • June 19, 2017

For Hepatitis C "I am halfway through my 12 weeks. The side effects I've had are headaches almost daily, mainly in the evening. Most of my joints have discomfort/pain in my upper body. These issues are tolerable by all means. I do get exhausted easily. I did my first blood test last week, and it appears that the virus is gone. I am getting anemia according to the test as well. So far, none of these side effects are horrible, just annoying. Keeping the prayers going for us. Will update more later."

9 / 10
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  • Anonymous
  • March 5, 2021

For Hepatitis C "I am a 46-year-old woman, and I have had Hep C genotype 4A for 29 years, with thankfully very little liver damage so far (it probably helps that I quit drinking 25 years ago). Tonight is my sixth night since starting the Epclusa—I had bizarrely dry lips the first two days despite drinking copious amounts of water (so dry they sort of tingled), but that seems to have passed. My main side effects so far are terribly raging mood swings and tiredness. But also I have a 16-month-old toddler, and we are living in a pandemic, and I work a pretty taxing job, so... who knows! I also just got a Covid vaccine three days ago, and there is definitely no data whether that might also be contributing. No other side effects so far, which is great because I was very worried about headaches and nausea. Feeling very grateful we all get to try this rather than the horrors of interferon. Will report back whether anything changes with the moodiness/fatigue."

5 / 10
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  • Any...
  • Taken for 1 to 6 months
  • April 17, 2025

For Hepatitis C "Just wanted to update my prior post from December. Since completing treatment, my viral load came back at zero. It had been at 20 at my midpoint check-up. I’ve had no side effects or issues since completing treatment in January. Please take this medication if you need it. Not worrying about hep C every day has been wonderful!"

10 / 10
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  • Bla...
  • Taken for less than 1 month
  • July 28, 2019

For Hepatitis C "On my 8th day now. I get what everyone says about the brain fog and a few mild headaches, but it is manageable. If it stays like it has, then it's well worth the feeling a bit rough for a while - I think. Good luck to anyone else who's on Epclusa. I hope it works for you all."

7 / 10
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  • H j...
  • Taken for 1 to 6 months
  • August 12, 2017

For Hepatitis C "I did the 12-week treatment of Epclusa. I am genotype 2. I started with 12,000,000 million, I am now hep C free. I have one more blood test left at the 3-month blood test. Anyway, here lately I have been feeling bad headaches, a rash, nauseated, and I'm just not sure what could be going on. Has anyone else had side effects even after taking the meds? During the treatment, it wasn't terribly bad, and I had some really good days as well."

7 / 10
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  • Ell...
  • Taken for 1 to 6 months
  • May 6, 2017

For Hepatitis C "I'm 51 F Hep C type 2. I just started taking the Epclusa. I'm 8 days in. I was expecting to be sick from it, but NO!! First day, I felt less fatigue. Less pain. Not having any bad side effects, a little more gas, and I feel a little irritated. Not to be gross, but I noticed my stool looked dark green. I'm very pleased with the lack of side effects and hope it continues to be the same through treatment and, of course, that it's working and rids my body of this horrible virus. I pray for all of us every night that we get cured. I'll update when I do my blood work on week 4. God bless everyone."

10 / 10
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  • Bri...
  • Taken for 1 to 6 months
  • July 8, 2018

For Hepatitis C "Let me say when I was first put on Mavyret. Within 3 days, I had the first psychotic episode of my life.....side effects they don't mention. Epclusa was fantastic, though. Day 1, I could feel the medicine hit, and I could also feel when it was metabolized a few hours later. I felt high day 1, but after that, not really. Honestly, maybe some mild relaxing effect. My first bloodwork came back viral load undetected and subsequent tests the same. I am done with the medicine now. Overall, I had such mild side effects it is hard to say that they even were side effects. I felt really tired for about 3 days after completing the medicine. Maybe a few slight headaches. I made sure to drink 90 oz of water a day and took the meds with food in the evening. These definitely helped curb side effects. If you feel sick at all, drink more pure water and take the meds with food."

10 / 10
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  • Gre...
  • Taken for 1 to 6 months
  • June 15, 2018

For Hepatitis C "Wanted to update my first post. The Epclusa for me has been awesome. Some fatigue and I have ringing in my ears (tinnitus?), but this has been mild. I have 18 days left to go, my numbers are good with no sign of hepatitis C. :) I knew I had it for a long time but was not insured, and the price was prohibitive, so I just lived with it. I had no idea how much of a mental burden that was until it was lifted. I am feeling healthy and free. If this is available to you and you're on the fence, just do it! To the people who are struggling, God bless and do not give up!"

10 / 10
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  • Jew...
  • Taken for less than 1 month
  • February 17, 2017

For Hepatitis C "I was diagnosed in May of last year, only because my Dr. wanted to 'rule out' HepC, but instead, I was one of the many 'unlucky' baby boomers that tested positive. I have Type 4, and I have/had no symptoms or indication of the virus except the positive blood test. I was also diagnosed with MALT lymphoma at the same time. I completed radiation therapy for the cancer in Dec 2016 and waited for the HepC treatment until the effects of radiation had passed. I started Epclusa 2 weeks ago, and I've had 0, none, nada side effects. In fact, I'm feeling pretty darn good! I've been worried that it's not working since I'm feeling nothing, but seeing that several people on this forum have had no side effects and a complete cure makes me very happy!"

9 / 10
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  • Wil...
  • Taken for 1 to 6 months
  • February 26, 2020

For Hepatitis C "Started taking the drug a month ago. Mild headache, a bit hard to sleep for a couple of weeks. Felt very emotional for about a week, but that went away. All in all, very little side effects compared to interferon, which I had to stop prematurely due to anger from the drug. Really gotta drink a bunch of water on this one. Dry mouth is helped with OTC Biotene mouthwash. When I wake up, I swish with that and it helps. Cheers!"

9 / 10
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  • Mar...
  • February 22, 2017

For Hepatitis C "I have hep C genotype 1, and I've had it for many years, I assume. Found out 13 years ago, but suspect I have had it for over 20. I have wanted treatment for many years, but raising a family and homeschooling my children, I just couldn't imagine feeling like I have the flu for a year. I'm so thankful for this medicine. I've had headaches and tiredness, some nausea, but I also have many great days with lots of energy. I have 29 more days to go, and I'm so thankful and excited about having this wonderful opportunity to get rid of this and only having to pay a $5 copayment. I am 53. Today is 2/22/17."

9 / 10
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  • Joe...
  • March 1, 2017

For Hepatitis C "I finished taking Epclusa in November 2016 after it was found that I still had hepatitis C genotype 3, even after I was treated in 2005 on an interferon ribavirin regimen for 26 weeks. Just two days ago, I received the news from my infectious disease doctor that Epclusa did not work, that I still have been found positive with the hepatitis C virus. For my wife and me, this is very sad news, and we are at a loss now as to what to do. My doctor is at a loss, and he has no clue on what to do next. I am reaching out to anyone that is reading this if they have known anybody that has taken this new drug and it has failed them, what were the next steps that they took."

1 / 10
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  • Can...
  • Taken for 1 to 6 months
  • January 17, 2019

For Hepatitis C "I've had hep C since 1994, and in 2010, I did the interferon, and it damn near killed me. Then, two years ago, I did the Vicaire pack, and it made my body swell up so bad that I had to be admitted into the hospital five different times for five days at a time. So I just started the Epclusa, I am two months into it, and I am undetected. At first, the only side effect I had was nausea, but now I'm extremely tired, and I'm having a lot of pain around where my liver sits, at the front side to back. But other than that, the medication is working great. I think I got about a month and a week left, something like that, I'll be done with my treatment March 1st. I've been on it since the end of November. I would highly recommend this medication for Hep C patients, this is the third one that I've tried and the only one that I've had success with so far."

10 / 10
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  • CCa...
  • Taken for 1 to 6 months
  • April 4, 2025

For Hepatitis C "More than 35 years with Hep C, was suffering, 1980s-2025, roughly huge 3 million viral load showed undetectable after 10 3/4 weeks. Just finished my 12th week. 1 pill a day today and-also today I am starting my 3-month official waiting period. I did get or have some cirrhosis. Now, due to the time passing with no Hep C treatment-this is easy to take meds. Follow the simple, easy rules, no problems. Urge anyone to receive this wonderful treatment. My wife of more than 35 years seems happier than me... :) I am also extremely thankful to all."

10 / 10
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  • Han...
  • July 31, 2019

For Hepatitis C "I just finished my first month. Although I haven’t gotten my blood work yet, I’ll share side effects. I wasn’t really coached on a lot and was told that the time of day you take it, day or night, doesn’t matter. Well, it does. Dr. said a lot of people have more problems if taking it at night. Did for me at least. I ended up in the ER on night three from uncontrollable vomiting, ear ringing, and migraines that woke me in the dead of night (all 3 nights). I switched to morning and had to be put on Zofran for nausea, and ibuprofen is an everyday thing. My liver aches randomly and never did before. The only symptoms I have now are migraines and tiredness. I must also note I am tapering off methadone, so I’m more moody, anxious already, and everything is heightened. Didn’t really consider the effect it’d have on me doing both, but my GI doctor wouldn’t stop pushing treatment on me. But also, I’m happy I did it and hopeful. The beginning was just a little tough."

8 / 10
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  • Sto...
  • Taken for 1 to 6 months
  • April 19, 2019

For Hepatitis C "After 3 weeks on Epclusa and no Hep C virus detected. First 4 days had brain fog, mild headaches, and muscle cramping. I'm in the 9th week, I feel pretty good. Ringing in the ears has started. I go to the gym to help with cramping. Eat every few hours and drink plenty of water."

8 / 10
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  • Sta...
  • Taken for less than 1 month
  • November 11, 2019

For Hepatitis C "Week 2 of Epclusa. Severe headaches that do not go away no matter how much water I drink. Tired a lot. Have to work, so I'm doing my best. Avoiding caffeine helps, but I'm still dizzy and weak. Having strange dreams and mood swings. But I want to be cured, so I'm keeping in close contact with my doctor and praying it gets better."

8 / 10
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