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What is the best time of day to take Epclusa?

Medically reviewed by Carmen Pope, BPharm. Last updated on June 7, 2022.

Official answer

by Drugs.com

Epclusa can be taken either in the morning or the evening, but it is important to take it at approximately the same time each day. Most people find it easier to take Epclusa in the morning because they take it as soon as they get up and that helps them to remember to take it at the same time every day. Sometimes if you plan on taking your tablets in the evening, you get busy and forget to take them, and it is not a good idea to take tablets just before going to bed. Epclusa can be taken with or without food, so you can take Epclusa either before breakfast, with breakfast, or after breakfast.

References
  • Epclusa (velpatasvir and sofosbuvir) Updated 05/2022 Gilead Sciences, Inc. https://www.drugs.com/pro/epclusa.html

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Some of the main differences between hepatitis B and C are:

  • Hepatitis B virus can be prevented with a vaccine, but not hepatitis C.
  • Hepatitis B and C are different viruses, but you can have both hepatitis B and hepatitis C at the same time.
  • Over 90% of people infected with hepatitis C who have not received treatment can be cured with 8 to 12 weeks of oral medications, but treatment for hepatitis B, if needed, may be long-term or lifelong.
  • There is no cure for hepatitis B, but once you recover from acute hepatitis B, you develop antibodies that protect you from the virus for life.
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The newest drugs for the treatment of hepatitis C include Mavyret (glecaprevir and pibrentasvir), Vosevi (sofosbuvir, velpatasvir, and voxilaprevir), and Epclusa (sofosbuvir and velpatasvir). All are FDA-approved for the treatment of chronic hepatitis C virus (HCV) genotype 1, 2, 3, 4, 5 or 6 infection without cirrhosis or with compensated cirrhosis (Child-Pugh A), as well as other uses. Continue reading

There is a chance that Epclusa may not work as well if you miss doses. Epclusa works by interfering with a protein and an enzyme needed by the hepatitis C virus to replicate and if you forget a dose, your blood levels of Epclusa can fall below the level needed to inhibit this protein or enzyme. Continue reading

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