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Does Epclusa work if you miss doses?

Medically reviewed by Carmen Pope, BPharm. Last updated on June 7, 2022.

Official answer


There is a chance that Epclusa may not work as well if you miss doses. Epclusa works by interfering with a protein and an enzyme needed by the hepatitis C virus to replicate and if you forget a dose, your blood levels of Epclusa can fall below the level needed to inhibit this protein or enzyme.

If you do accidentally forget to take a dose, take it as soon as you remember. If it is almost time for your next dose, do not double up your dose, instead, take one dose as usual and call your healthcare provider and tell them that you have missed a dose.

Epclusa is usually taken once daily for 12 weeks. Do everything you can to remind yourself to take Epclusa at approximately the same time each day. Five ways to help you remember to take Epclusa include:

  • Take your tablets in the morning when you first get out of bed
  • Set an alert or alarm on your phone that reminds you to take your Epclusa
  • Ask a friend or family member to ask you each day if you have taken your Epclusa tablets
  • Hang a calendar on your wall and mark off every day as soon as you have taken your Epclusa tablets
  • Buy a pill box that holds at least 7 days of Epclusa tablets and fill it up once a week. Then you can easily see if you have taken your daily dose.
  • Epclusa (velpatasvir and sofosbuvir) Updated 05/2022 Gilead Sciences, Inc.
  • Epclusa FAQs.

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