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Epclusa (sofosbuvir / velpatasvir) Drug Interactions

A total of 188 drugs are known to interact with Epclusa (sofosbuvir / velpatasvir).

  • 57 major drug interactions
  • 125 moderate drug interactions
  • 6 minor drug interactions

Show all medications in the database that may interact with Epclusa (sofosbuvir / velpatasvir).

Check for interactions

Type in a drug name to check for interactions with Epclusa (sofosbuvir / velpatasvir).

Most frequently checked interactions

View interaction reports for Epclusa (sofosbuvir / velpatasvir) and the medicines listed below.

  • albuterol (Ventolin, Ventolin HFA, ProAir HFA, Proventil, Proventil HFA, ProAir RespiClick, AccuNeb, Respirol, ProAir Digihaler, Volmax, Airet, Vospire ER)
  • amlodipine (Norvasc)
  • aspirin (Ecotrin, Acetylsalicylic Acid, Aspir 81, Bayer Aspirin, Aspirin Low Strength, Bufferin, Arthritis Pain, Easprin, Ascriptin, Fasprin, Low Dose ASA, Buffered Aspirin, Aspir-Low, Durlaza, Ascriptin Enteric, Acuprin 81, Halfprin, Aspergum, Empirin, Bayer Children's Aspirin, Aspirin Lite Coat, Aspi-Cor, Aspirtab, Ecotrin Adult Low Strength, Ecotrin Maximum Strength, Entercote, Minitabs, St. Joseph Aspirin, Ascriptin Maximum Strength, Arthritis Foundation Pain Reliever, Bayer Aspirin with Heart Advantage, Bufferin Low Dose, Medi-Seltzer, Sloprin, St. Joseph 81 mg Chewable Aspirin, ZORprin, Aspiritab, Bayer Aspirin Extra Strength Plus, Buffex, Extra Strength Bayer, Genacote, Gennin-FC, Genprin, Litecoat Aspirin, Tri-Buffered Aspirin, Entaprin, Bufferin Arthritis Strength, Bufferin Extra Strength, Therapy Bayer, Stanback Analgesic, Norwich Aspirin, St. Joseph 81 mg Aspirin Enteric Safety-Coated, Ecpirin, Bayer Women's Aspirin With Calcium, Zero-Order Release, YSP Aspirin, Miniprin, Bayer Aspirin Regimen, Migralex, Heartline, Bayer Advanced Aspirin, Buffasal)
  • bupropion (Wellbutrin, Wellbutrin XL, Wellbutrin SR, Zyban, Aplenzin, Buproban, Budeprion, Forfivo XL, Budeprion XL, Budeprion SR)
  • caffeine (Vivarin, Caffedrine, Diurex Ultra, 357 HR Magnum, Overtime, Valentine, NoDoz, Jet Alert Regular Strength, Jet Alert Double Strength, Jet Alert Maximum Strength, ConRx Alert, Pep-Back ReCharge, Pep-Back Peak Performance, Keep Alert, Stay Awake, Verv, Alert, Stat Awake, Stay Alert, NoDoz Maximum Strength, Wakespan, Lucidex, Diurex Maximum Relief Water Caps, Pep-Back Ultra, Cafcit, Enerjets, Fastlene, Keep Going, Molie)
  • carvedilol (Coreg, Coreg CR)
  • cyclobenzaprine (Flexeril, Fexmid, Amrix, Comfort Pac with Cyclobenzaprine)
  • furosemide (Lasix, Diaqua-2, Lo-Aqua)
  • gabapentin (Neurontin, Gralise, Gabarone, Fanatrex)
  • Humalog (insulin lispro)
  • hydrochlorothiazide / losartan (Hyzaar)
  • levothyroxine (Synthroid, Levoxyl, Tirosint, Eltroxin, Levothroid, Levothyrox, Euthyrox, Unithroid, Levo-T, Oroxine, L Thyroxine Roche, Eutroxsig, Novothyrox, Tirosint-Sol, Levotabs, Levotec, Evotrox)
  • lisinopril (Zestril, Prinivil, Qbrelis)
  • losartan (Cozaar)
  • metformin (Glucophage, Glumetza, Fortamet, Glucophage XR, Riomet)
  • omeprazole (Prilosec, Prilosec OTC, Zegerid (Original Formulation), Omesec)
  • ribavirin (Moderiba, Copegus, Ribasphere, Virazole, Rebetol, RibaTab, RibaPak)
  • spironolactone (Aldactone, CaroSpir)
  • tamsulosin (Flomax)
  • trazodone (Desyrel, Oleptro, Desyrel Dividose)
  • venlafaxine (Effexor, Effexor XR)
  • Xifaxan (rifaximin)

Epclusa (sofosbuvir / velpatasvir) disease interactions

There is 1 disease interaction with Epclusa (sofosbuvir / velpatasvir):

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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