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Drug interactions between Epclusa and omeprazole

Results for the following 2 drugs:
Epclusa (sofosbuvir/velpatasvir)
omeprazole

Interactions between your drugs

Major

omeprazole ↔ velpatasvir

Applies to:omeprazole and Epclusa (sofosbuvir/velpatasvir)

Depending on the dose, omeprazole may interfere with the absorption of velpatasvir and reduce its effectiveness. Talk to your doctor or pharmacist if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment of omeprazole to safely use both medications. You should take velpatasvir with food and at least 4 hours before the dose of omeprazole. Contact your doctor if your symptoms worsen or your condition changes. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Drug and food interactions

No results found in our database - however, this does not necessarily mean no interactions exist. Always consult with your doctor or pharmacist.

Therapeutic duplication warnings

No therapeutic duplications were found for your selected drugs.

Drug Interaction Classification

The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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