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What antibiotics are used to treat chlamydia and gonorrhea?

Medically reviewed by Last updated on March 31, 2023.

Official answer


From the 2015 Sexually Transmitted Disease (STD) guidelines, the CDC recommends treatment for a gonorrhea-chlamydia coinfection with azithromycin (Zithromax) 1 gram given orally in a single dose, plus ceftriaxone (Rocephin) 250 mg given intramuscularly as first-line therapy.

As dual therapy, ceftriaxone and azithromycin should be administered together on the same day, preferably at the same time, and under direct observation by a health care provider.

Co-infection of gonorrhea with chlamydia can be found commonly in the community setting.


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