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How to transition to Invega Hayfera from Invega Trinza or Invega Sustenna?

Medically reviewed by Carmen Fookes, BPharm. Last updated on Oct 6, 2021.

Official answer

by Drugs.com

Before transitioning to Invega Hayfera, a person must have been administered Invega Sustenna for at least 4 months or Invega Trinza for at least one three-month cycle and tolerated either of them well.

Switching from Invega Sustenna to Invega Hayfera

For a seamless transition, it is recommended that the last two doses of Invega Sustenna are the same dosage strength. Start Invega Hayfera up to 7 days before, on, or 7 days after the day the next 1-month Invega Sustenna dose was due. The following dosage guide is recommended by the manufacturer:

  • If the last dose of Invega Sustenna was 156 mg, then initiate Invega Hayfera at 1092 mg
  • If the last dose of Invega Sustenna was 234 mg, then initiate Invega Hayfera at 1560 mg.

Invega Hafyera should be administered once every 6 months by a health care professional into either the deltoid muscle of the arm or the gluteal muscle of the buttocks.

Switching from Invega Trinza to Invega Hayfera

Start Invega Hayfera up to 2 weeks before, on, or 2 weeks after the next 3-monthly Invega Trinza dose was due. The following dosage guide is recommended by the manufacturer:

  • If the last dose of Invega Trinza was 546 mg, then initiate Invega Hayfera at 1092 mg
  • If the last dose of Invega Trinza was 819 mg, then initiate Invega Hayfera at 1560 mg.

Invega Hafyera should be administered once every 6 months by a health care professional into either the deltoid muscle of the arm or the gluteal muscle of the buttocks.

References
  • Invega Sustenna (paliperidone palmitate). Updated 08/2021. Janssen Pharmaceuticals, Inc. https://www.drugs.com/pro/invega-sustenna.html
  • Invega Trinza (paliperidone palmitate). Updated 08/2021. Janssen Pharmaceuticals, Inc. https://www.drugs.com/pro/invega-trinza.html#s-34069-5
  • Invega Hafyera. (paliperidone palmitate). Updated 09/2021. Janssen Pharmaceuticals, Inc.
  • https://www.drugs.com/pro/invega-hafyera.html#s-34069-5

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