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How to transition to Invega Trinza from Invega Sustenna ?

Medically reviewed by Carmen Fookes, BPharm. Last updated on Oct 6, 2021.

Official answer

by Drugs.com

Before people transition to Invega Trinza, they need to have been administered Invega Sustenna for at least 4 months and tolerated it well. For a seamless transition, it is recommended that the last two doses of Invega Sustenna are the same dosage strength before starting Invega Trinza. Start Invega Trinza up to 7 days before, on, or 7 days after the day the next 1-month Invega Sustenna dose was due. Your doctor will choose a starting dose of Invega Trinza that is 3.5-fold higher than the last Invega Sustenna dose, for example:

  • If the last dose of Invega Sustenna was 78 mg then Invega Trinza should be initiated at 273 mg
  • If the last dose of Invega Sustenna was 117 mg then Invega Trinza should be initiated at 410 mg
  • If the last dose of Invega Sustenna was 156 mg then Invega Trinza should be initiated at 546 mg
  • If the last dose of Invega Sustenna was 234 mg then Invega Trinza should be initiated at 819 mg.
References
  • Invega Sustenna (paliperidone palmitate). Updated 08/2021. Janssen Pharmaceuticals, Inc. https://www.drugs.com/pro/invega-sustenna.html
  • Invega Trinza (paliperidone palmitate). Updated 08/2021. Janssen Pharmaceuticals, Inc. https://www.drugs.com/pro/invega-trinza.html#s-34069-5

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