Skip to main content

Invega Trinza

Generic name: paliperidone palminate
Dosage form: extended-release suspension for intramuscular injection
Drug class: Atypical antipsychotics

Medically reviewed by Philip Thornton, DipPharm. Last updated on Apr 4, 2023.

What is Invega Trinza?

Invega Trinza is an atypical antipsychotic that is given once every 3 months. It is used to treat a mental disorder called schizophrenia.

Invega Trinza contains paliperidone. Another well-known antipsychotic drug called Risperdal (risperidone) is converted into paliperidone once it is in the body. Invega Trinza is an extended-release version of paliperidone that helps to overcome the fluctuations in blood levels of the drug that are seen after it is taken by mouth as an immediate-release formulation such as Risperdal. It also helps to avoid the problem of remembering to take a medication everyday.

It is not fully understood how Invega Trinza works, but it helps to adjust the levels of chemicals in the brain called dopamine and serotonin. These chemicals are called neurotransmitters and it's thought that an imbalance in these chemicals plays a role in schizophrenia.

Invega Trinza was approved by the US Food and Drug Administration (FDA) in 2015.

What is Invega Trinza used for?

Invega Trinza is a prescription medicine given by injection by a healthcare professional and used to treat schizophrenia.

Invega Trinza is used in people who have been treated with Invega Sustenna 1 time a month injections for at least 4 months.

It is not known if Invega Trinza is safe and effective in children under 18 years of age.

Important Information

Invega Trinza can cause serious side effects, including:

Who should not receive Invega Trinza?

Do not receive Invega Trinza if you:

What should I tell my doctor before receiving Invega Trinza?

Before you receive Invega Trinza, tell your healthcare provider about all your medical conditions, including if you:

How should I receive Invega Trinza?

What happens if I miss a dose?

Missing doses of Invega Trinza should be avoided. To manage missed doses on exceptional occasions, refer to the Full Prescribing Information.

What should I avoid while receiving Invega Trinza?

Invega Trinza may affect your ability to make decisions, think clearly, or react quickly. Do not drive, operate heavy machinery, or do other dangerous activities until you know how Invega Trinza affects you.

Avoid getting overheated or dehydrated.

Dosing information

Lybalvi, Rexulti, Vraylar, quetiapine, aripiprazole, olanzapine, Abilify, risperidone, Seroquel

What are the side effects of Invega Trinza?

Invega Trinza may cause serious side effects, including:

The most common side effects of Invega Trinza include: injection site reactions, weight gain, headache, upper respiratory tract infections, feeling restlessness or difficulty sitting still, slow movements, tremors, stiffness and shuffling walk.

Tell your healthcare provider if you have any side effect that bothers you or does not go away.

These are not all the possible side effects of Invega Trinza. For more information, ask your healthcare provider or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Interactions

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

Know the medicines you take. Keep a list of them to show to your healthcare provider or pharmacist when you get a new medicine.

Does Invega Trinza interact with my other drugs?

Enter medications to view a detailed interaction report using our Drug Interaction Checker.

Preganancy and breastfeeding

Tell your doctor is your are pregnant or plan to become pregnant. It is not known if Invega Trinza will harm your unborn baby.

If you become pregnant while taking Invega Trinza, talk to your healthcare provider about registering with the National Pregnancy Registry for Atypical Antipsychotics. You can register by calling 1-866-961-2388 or visit http://womensmentalhealth.org/clinical-and-research-programs/pregnancyregistry/.

Infants born to women who are treated with Invega Trinza may experience symptoms such as tremors, irritability, excessive sleepiness, eye twitching, muscle spasms, decreased appetite, difficulty breathing, or abnormal movement of arms and legs. Let your healthcare provider know if these symptoms occur.

Tell your doctor if you are breastfeeding or plan to breastfeed. Invega Trinza can pass into your breast milk. Talk to your healthcare provider about the best way to feed your baby if you receive Invega Trinza.

Storage

Store Invega Trinza at room temperature 20°C to 25°C (68°F to 77°F); excursions between 15°C and 30°C (59°F and 86°F) are permitted. Do not mix with any other product or diluent.

What are the ingredients in Invega Trinza?

Active ingredient: paliperidone palmitate

Inactive ingredients: polysorbate 20, polyethylene glycol 4000, citric acid monohydrate, sodium dihydrogen phosphate monohydrate, sodium hydroxide, and water for injection

Invega Trinza is manufactured by Janssen Pharmaceutica NV Beerse, Belgium.

Popular FAQ

Invega Sustenna vs Invega Trinza vs Invega Hafyera. What's the difference?

The difference between Invega Sustenna, Invega Trinza, and Invega Hayfera is the length of time they last in the body. Invega Sustenna lasts for 1 month, Invega Trinza lasts for 3 months, and Invega Hayfera lasts for 6 months and only needs to be given twice a year. Before transitioning to Invega Hayfera, patients must be adequately treated with Invega Sustenna for at least 4 months, or Invega Trinza for at least one 3-month injection cycle. Continue reading

How to transition to Invega Trinza from Invega Sustenna ?

Before people transition to Invega Trinza, they need to have been administered Invega Sustenna for at least 4 months and tolerated it well. For a seamless transition, it is recommended that the last two doses of Invega Sustenna are the same dosage strength before starting Invega Trinza. Start Invega Trinza up to 7 days before, on, or 7 days after the day the next 1-month Invega Sustenna dose was due. Choose a starting dose of Invega Trinza that is 3.5-fold higher than the last Invega Sustenna dose. Continue reading

How to transition to Invega Hayfera from Invega Trinza or Invega Sustenna?

Before transitioning to Invega Hayfera, a person must have been administered Invega Sustenna for at least 4 months or Invega Trinza for at least one three-month cycle and tolerated either of them well. Continue reading

How does Invega Trinza work?

Invega Trinza (paliperidone palmitate) is a long-acting injectable medication for schizophrenia that works by adjusting the balance of natural chemicals (neurotransmitters) in your brain. Symptoms such as hallucinations, agitation, and disorganized thinking and behavior can be decreased by restoring the balance of these neurotransmitters. Continue reading

How is Invega Trinza administered?

Invega Trinza (paliperidone palmitate) is a long-acting injection given into the muscle of your upper arm (deltoid muscle) or buttock (gluteal muscle). It is given once every 3 months for the treatment of schizophrenia. Your healthcare provider will give you this injection each time. Continue reading

How often is Invega Trinza given?

Invega Trinza (paliperidone palmitate) is a long-acting intramuscular injection given once every three months for the treatment of schizophrenia. Injections are given only by a healthcare professional. Invega Trinza is used in people who have already been treated with once-monthly Invega Sustenna injections for at least 4 months. Continue reading

Can you drink alcohol while taking Invega Sustenna?

You should avoid the use of alcohol while being treated with Invega Sustenna (paliperidone palmitate). Combining alcohol with Invega Sustenna can increase side effects like dizziness, drowsiness, and trouble concentrating. This may also affect your ability to make decisions, think clearly, or react quickly. Continue reading

View more FAQ

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.