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Medications for Interstitial Cystitis

Other names: Bladder Pain Syndrome; Cystitis, Interstitial

About Interstitial Cystitis

Interstitial cystitis (IC) is a chronic urinary health issue which it not caused by infection or any other medical condition.  Symptoms include pain or pressure in the bladder or lower urinary tract area, which often increases as the bladder fills.  There is also increased daytime and nighttime urinary frequency and urgency.

Drugs used to treat Interstitial Cystitis

The following list of medications are in some way related to, or used in the treatment of this condition.

Drug name Rating Reviews Activity ? Rx/OTC Pregnancy CSA Alcohol
Elmiron 7.5 98 reviews
Rx B N

Generic name: pentosan polysulfate sodium systemic

Drug class: miscellaneous genitourinary tract agents

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

phenazopyridine 7.4 52 reviews
Rx/OTC B N

Generic name: phenazopyridine systemic

Brand names:  Pyridium, Uristat, Azo-Standard, Azo Urinary Pain Relief, Uricalm, Baridium, Prodium, Azo-Gesic, Azo-Septic, Re-Azo …show all

Drug class: miscellaneous genitourinary tract agents

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

amitriptyline Off-label 8.2 66 reviews
Rx C N X

Generic name: amitriptyline systemic

Drug class: tricyclic antidepressants

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off-label: Yes

hydroxyzine Off-label 6.6 9 reviews
Rx N N X

Generic name: hydroxyzine systemic

Drug class: miscellaneous anxiolytics, sedatives and hypnotics, antihistamines

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off-label: Yes

Pyridium 8.0 9 reviews
Rx/OTC B N

Generic name: phenazopyridine systemic

Drug class: miscellaneous genitourinary tract agents

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

pentosan polysulfate sodium 7.6 103 reviews
Rx B N

Generic name: pentosan polysulfate sodium systemic

Brand name:  Elmiron

Drug class: miscellaneous genitourinary tract agents

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph

Uristat 9.0 3 reviews
Rx/OTC B N

Generic name: phenazopyridine systemic

Drug class: miscellaneous genitourinary tract agents

For consumers: dosage, interactions, side effects

trospium Off-label 10 2 reviews
Rx C N X

Generic name: trospium systemic

Drug class: urinary antispasmodics

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off-label: Yes

Azo-Standard 9.1 7 reviews
Rx/OTC B N

Generic name: phenazopyridine systemic

Drug class: miscellaneous genitourinary tract agents

For consumers: dosage, interactions, side effects

Azo Urinary Pain Relief 4.3 7 reviews
Rx/OTC B N

Generic name: phenazopyridine systemic

Drug class: miscellaneous genitourinary tract agents

For consumers: dosage, interactions, side effects

imipramine 9.0 1 review
Rx N N X

Generic name: imipramine systemic

Drug class: tricyclic antidepressants

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Uricalm 5.0 2 reviews
Rx/OTC B N

Generic name: phenazopyridine systemic

Drug class: miscellaneous genitourinary tract agents

For consumers: dosage, interactions, side effects

Baridium Rate Add review
Rx/OTC B N

Generic name: phenazopyridine systemic

Drug class: miscellaneous genitourinary tract agents

For consumers: dosage, interactions, side effects

dimethyl sulfoxide Rate Add review
Rx C N

Generic name: dimethyl sulfoxide systemic

Brand names:  Rimso-50, Cryoserv

Drug class: miscellaneous genitourinary tract agents

For consumers: dosage, interactions, side effects

Prodium Rate Add review
Rx/OTC B N

Generic name: phenazopyridine systemic

Drug class: miscellaneous genitourinary tract agents

For consumers: dosage, interactions, side effects

Rimso-50 Rate Add review
Rx C N

Generic name: dimethyl sulfoxide systemic

Drug class: miscellaneous genitourinary tract agents

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

Azo-Gesic Rate Add review
Rx/OTC B N

Generic name: phenazopyridine systemic

Drug class: miscellaneous genitourinary tract agents

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

Azo-Septic Rate Add review
Rx/OTC B N

Generic name: phenazopyridine systemic

Drug class: miscellaneous genitourinary tract agents

For consumers: dosage, interactions, side effects

Cryoserv Rate Add review
Rx C N

Generic name: dimethyl sulfoxide systemic

Drug class: miscellaneous genitourinary tract agents

For consumers: dosage, interactions, side effects

Re-Azo Rate Add review
Rx/OTC B N

Generic name: phenazopyridine systemic

Drug class: miscellaneous genitourinary tract agents

For consumers: dosage, interactions, side effects

Learn more about Interstitial Cystitis

IBM Watson Micromedex

Symptom checker

Symptoms and treatments

Mayo Clinic Reference

Legend

Rating For ratings, users were asked how effective they found the medicine while considering positive/adverse effects and ease of use (1 = not effective, 10 = most effective).
Activity Activity is based on recent site visitor activity relative to other medications in the list.
Rx Prescription Only.
OTC Over the Counter.
Rx/OTC Prescription or Over the Counter.
Off-label This medication may not be approved by the FDA for the treatment of this condition.
EUA An Emergency Use Authorization (EUA) allows the FDA to authorize unapproved medical products or unapproved uses of approved medical products to be used in a declared public health emergency when there are no adequate, approved, and available alternatives.
Pregnancy Category
A Adequate and well-controlled studies have failed to demonstrate a risk to the fetus in the first trimester of pregnancy (and there is no evidence of risk in later trimesters).
B Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.
C Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
D There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
X Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use in pregnant women clearly outweigh potential benefits.
N FDA has not classified the drug.
Controlled Substances Act (CSA) Schedule
N Is not subject to the Controlled Substances Act.
1 Has a high potential for abuse. Has no currently accepted medical use in treatment in the United States. There is a lack of accepted safety for use under medical supervision.
2 Has a high potential for abuse. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse may lead to severe psychological or physical dependence.
3 Has a potential for abuse less than those in schedules 1 and 2. Has a currently accepted medical use in treatment in the United States. Abuse may lead to moderate or low physical dependence or high psychological dependence.
4 Has a low potential for abuse relative to those in schedule 3. It has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 3.
5 Has a low potential for abuse relative to those in schedule 4. Has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 4.
Alcohol
X Interacts with Alcohol.

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Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.