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Dimethyl Sulfoxide Dosage

Medically reviewed on September 24, 2018.

Applies to the following strengths: 50%; 99%

Usual Adult Dose for:

Additional dosage information:

Usual Adult Dose for Cystitis

Interstitial cystitis:
Instill 50 mL of dimethyl sulfoxide into the bladder by catheter or Asepto syringe. Allow to remain for 15 minutes. The medication is expelled by spontaneous voiding.
Maintenance dose: Repeat every 2 weeks until maximum symptomatic relief obtained
Duration of therapy: Time intervals between therapy may be increased appropriately

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available


Consult WARNINGS section for dosing related precautions.


Data not available

Other Comments

Administration advice:
-Apply an analgesic lubricant gel to urethra prior to insertion of catheter to avoid spasm.
-Administration of an oral analgesic medication or suppository containing belladonna and opium prior to instillation can reduce bladder spasms.
-The initial treatment, and possibly the second and third should be done under anesthesia (saddle block) in patients with severe interstitial cystitis and very sensitive bladders.

Storage requirements: Protect from strong light

General: Instilled in the bladder on an inpatient or out-patient basis determined by the physician

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.