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Tofranil User Reviews & Ratings

Tofranil has an average rating of 6.0 out of 10 from a total of 8 reviews on Drugs.com. 67% of reviewers reported a positive experience, while 20% reported a negative experience.

Reviews for Tofranil

  • conrad
  • January 24, 2010

For Depression "I suffered from depression on and off till I was 33. My doctor prescribed a couple of medicines without success. Tried Tofranil because my mother took it in the late 1950s. Noticed a gradual improvement over 1 to 4 months with the full effect over a period of about 12 months. Medicine did not work at 100 mg, so went up to 250 mg, then 200 mg. Some small price side effects include dry mouth (gum, Tic Tac remedy). The medicine makes you sleepy about 2 hours after ingestion. Get ready for a good night's sleep, increased appetite, and feeling more relaxed than ever before. I remember the first sign of the Tofranil working was when I went outside one day and the sun seemed so bright, and I was happier to be alive. That was 25 years ago."

8 / 10
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249 Report
  • Anonymous
  • Taken for 1 to 6 months
  • June 20, 2012

For Panic Disorder "Tofranil is THE medicine to take for Panic Disorder. I was diagnosed with Panic Disorder recently, and I was a complete mess. Depressed, suicidal, anxious, the works. My primary care Dr. gave me Xanax. The Xanax helped, but only for short spurts. It also made me more depressed. I was taking up to 3 mg per day, and barely functioning. I got in to see a Psychiatrist, and he is older and more experienced. He immediately knew I had Panic Disorder, and started me on Tofranil. Tofranil absolutely stopped the panic attacks cold. I have been able to cut the Xanax way back, and feel, dare I say, normal. Tofranil is an old medicine, so many docs don't or won't try it. Newer is not always better."

10 / 10
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200 Report
  • Anonymous
  • November 15, 2011

For Panic Disorder "I had my first panic attacks immediately following the birth of my first son 18 years ago when I was 28 years old. The panic attacks were horrific and occurred randomly. I was prescribed a few different medications that weren't successful, but when I was prescribed Imipramine, I felt I had my life back. I doubt that I could have continued to be a primary school teacher without Imipramine. It has really been a miracle medication to me. When doctors hear that I take Imipramine, they usually comment that it is a really old drug that has been around since the 60's. Then they ask if I'd like to try one of the newer drugs. No way! I feel perfect on Imipramine. I can't say enough great things about it."

10 / 10
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170 Report
  • Anonymous
  • September 17, 2009

For Panic Disorder "I had suffered with panic attacks since I was around 14 years old. There came a time when I had shock treatments because back in the 60's not much was known about these kinds of illnesses. Later on, I became completely housebound for 8 years. I heard about Tofranil and decided to try it. Within 3 weeks I was able to not only get out of my house but go about 3 blocks away. It takes time, but if it had not been for Tofranil combined with Xanax I would still be home bound. It works, no two ways about it. When nothing else did. The only side effects were sleepiness until it gets into your system (2 weeks for me) and dry mouth. But for me that was nothing to getting my life back."

10 / 10
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141 Report
  • Crobo...
  • Taken for 1 to 6 months
  • May 8, 2024

For Depression "Started with 25mg of Tofranil and worked our way up to 75mg. It has been very effective for my depression/anxiety. At first, it made me a little drowsy, but that is no longer the case. I take it midday now. Blood pressure and pulse are within the normal range. No side effects besides a slight increase in appetite."

10 / 10
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1 Report

Are you taking this medicine?

  • Jo212
  • June 27, 2010

For Panic Disorder "I have suffered with Panic Attacks all my life but went undiagnosed until 1989. I am now 58 and trust me when I tell you that there is no cure. In my initial diagnosis I was started on Tofranil as an inpatient. After my discharge from the hospital I went 5 entire years without having a panic attack. When they resumed I had to be re-hospitalized and it was there I was put on Klonopin, which I have essentially been off of for a year. I am having constant panic attacks. My daughter does not want me to resume Klonopin as when on it I slept all the time. I did this search to see if Tofranil is still being used for panic disorder and I see that it is. I plan to have my psychiatrist to put me back on it as it really worked."

10 / 10
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106 Report
  • LUCCA
  • November 15, 2009

For Interstitial Cystitis "For 3 years I have been battling bladder cancer. My bladder has shrunk, the pain has been great, the need to urinate is every 15 minutes or so. I have had 9 biopsies, some malignant and more recently 3 in a row benign. I have interstitial cystitis and started using Tofranil 5 months ago. Over the course of those 5 months Tofranil has gradually eliminated the pain and lengthened the time to urinate to once per hour. To me, it is a miracle drug and I continue to take it with no side effects whatsoever."

9 / 10
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103 Report
  • XXXXX...
  • January 2, 2010

For Night Terrors "I had panic attacks (Night Terrors) for over a year or more and had lost hope for medication to help. Since the first night of taking Tofranil, I slept normal without the 3-4 am wake up(night terror) and have been free of them for 12 years without changing my medication. I am so thankful to have finely found and inexpensive medicine that actually worked from the first dose."

10 / 10
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76 Report
  • Anonymous
  • August 2, 2009

For Depression "At first this medicine seemed great. Was taking it for depression and generalized anxiety disorder. After a week on the lowest dose I started having bad side effects. I was shaving one morning and noticed my face, lips and arm felt numb. Doctor reduced my dosage to 10mg that worked okay for a week then same side effects."

4 / 10
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47 Report
  • Amy
  • Taken for 1 to 6 months
  • June 2, 2020

For Depression "Tofranil made me painfully constipated, very nervous, irritable, between doses, I'd get extremely weepy and emotionally distraught... it was the only time in my life that I felt live was too hard. When I started experiencing heart palpitations, I stopped taking it. I have CPTSD and Borderline"

2 / 10
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9 Report
  • Kam...
  • Taken for less than 1 month
  • February 17, 2016

For Depression "Waste of 75 bucks. My mood only increased slightly, and in exchange I got terrible bouts of dizziness and vertigo. Most of the time I felt like I'd been shot with a tranquilizer dart. Horrible experience. After only a week or so, I started to get nausea as well, so I had to stop. I regret spending money on this med."

2 / 10
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13 Report
  • Anonymous
  • April 26, 2010

For Depression "Best and least expensive. Came off Celexa because of side effect. Be patient, it works in about 3 weeks."

10 / 10
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110 Report
  • Samba...
  • August 1, 2013

For Panic Disorder "Nightmares, hard to sleep."

4 / 10
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28 Report
  • Anonymous
  • November 18, 2009

For Primary Nocturnal Enuresis "I used this most of my childhood and it didn't really work."

3 / 10
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21 Report
  • Patty
  • Taken for 1 to 6 months
  • February 28, 2022

For Depression "I have been on it a few months and feel great. Was put on this for IBS and depression. Been great so far!"

9 / 10
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5 Report

Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.