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User Reviews for Imipramine

Also known as: Tofranil, Tofranil-PM

The following information is NOT intended to endorse drugs or recommend therapy. While these reviews might be helpful, they are not a substitute for the expertise, skill, knowledge and judgement of healthcare practitioners in patient care.

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Summary of Imipramine reviews 7.3 43 reviews

Reviews for Imipramine

Miracles88 · Taken for 10 years or more June 27, 2019

For Depression: "The last few months my refill for this medication has been on back order from my pharmacy. Why ?"

Was better before May 27, 2019

For Depression: "This drug does something that effects one's entire body. I'm far more worried now that my heart will stop than about the depression it that this med was given for. Nearly 45 hours since last dose and I still can't feel my skin. Horrible horrible drug."

Floss · Taken for 10 years or more March 26, 2019

For Depression: "When I was 50 years old my depression was very acute and I needed hospital care and the NHS provided imipramine at 200mg a day. I am now 74 years old and have not had an acute episode in all that time."

Ohio Buckeye February 12, 2019

For Irritable Bowel Syndrome: "I was placed on Imipramine, 10 mg. Taken at bedtime. 3rd week after starting it, I began having nerve-like pain & burning down both legs into my feet, lower back pain & muscle spasms in back and legs. I couldn't sleep & was irritable. 3 days later I started noticing balance & coordination difficulties. It was so bad I was finding it hard to stand & walk, often falling into walls. I was dizzy & shaky. My cognitive abilities were diminished. Days later, close to the end of week 3 of being on the Imipramine, I began to have nerve-like pain in my arms & hands, my lips & tongue were numb & lips peeling excessively. I was sure it was the imipramine by then, and stopped taking it at week 4. 30 hours after my last dose, I noticed a slight improvement of side effects. 4-5 days later all the side effects were greatly reduced & by 7 days after the last dose of the Imipramine, all symptoms had stopped & I began to feel like my normal. I never noticed that it helped the IBS."

Snake · Taken for 10 years or more January 13, 2019

For Depression: "Male 70 years old as of 2019. Started taking imipramine in 1995 for anxiety and depression. Been a lifesaver of a medication. Started at 100mg at bedtime but slowly reduced to my present dose of 50mg at bedtime and have been taking this dose for 17 years. Had tried SSRI's prior to the imipramine and had terrible reactions so doctor gave me the tried and true imipramine. It saved my life."

Sky · Taken for 1 to 6 months December 11, 2018

For Depression: "I was severely depressed for a year and literally never left my bed. At 35 years old I was a Professional woman working full time with 2 children (who l was bringing up with the help of a full time nanny whilst l was at work and unwell - she was an angel) l was terrified the sun would never shine again. Then my GP hospitalised me and l was introduced to Imipramine at 200mg a day in two split doses. Initially it totally knocked me out - no other side effects though, then dose reduced to 150mg a day then 75mg a day. l began to feel “me" again - fit, bothered about my appearance, wanting to socialise, really optimistic about the future and confident that l could cope. I returned home on 75mg a day and after a week took the children 10 and 8 on holiday for 3 weeks abroad!! Felt a little scary but we had great family bonding time and l was back at work within two months and off the Imipramine! For me it saved my life and the children will always have a mother!"

linda · Taken for 1 to 2 years April 10, 2018

For Depression: "This was the first and best drug used to treat my severe depression. Before I took it I did not have enough energy to look for work nor could I hold up the newspaper to read it. I had been nauseous and eating little and I could not sleep beyond 3 hours. I had been very achey and exhausted and in a state of fatigue for greater than 6 months. After a month of imipramine I regained appetite, was no longer achey and I could sleep through the night. I got better, returned to work and was able to slowly wean off it after 18 months."

sickman2 February 15, 2018

For Depression: "made me sick"

larswy · Taken for 10 years or more January 5, 2018

For Depression: "Good for depression"

Sulley1130 · Taken for 1 to 2 years November 13, 2017

For Depression: "I was on imipramine for a little over a year, after trying every other antidepressant known to man. At first I noticed a major change. It was the best I had felt in years. I was back to doing things that I used to do and felt great. It also helped me to sleep at night. The effects of the med started to decrease so we increased the dose until I was eventually on 100mg a day. That's when the side effect started. I went in for a routine doctor visit and my resting heart rate was 130. Of course panic set in and I had a bunch of tests ran on my heart, everything was normal. The only thing different was the increase in imiprimine. It caused me tachycardia. So now I am in the process of weaning off of it. Onto something else."

Miccael October 17, 2017

For Depression: "This drug took an awfully long time to work. I hadn't been able to notice its subtle effects until about 2 months into treatment. It does lift your mood up by a tiny fraction, is great for general anxiety and it sparks up your motivation a bit. I had been on this medication alone for no avail, but when I paired it with an SSRI (Zoloft), it made a huge difference. I recommend this combination for treatment of depression."

anotherpersonwithproblems · Taken for 1 to 6 months July 24, 2017

For Depression: "25mg, once a day at night. For the first 7-8 weeks of taking this medication there was no positive effect on my mood, around week 3/4 my mood was noticeably worse. During the 7-8 week period I constantly felt disconnected and lacked any sort of motivation or energy to engage in any activity that involved thinking, especially social situations. I would constantly have a dry mouth and dry eyes and in addition I also had trouble urinating in the morning and when standing up I would feel light headed and dizzy for a few seconds, this was worse if I had been lying down. However, now my mood is much more stable and the side effects are gone but if I miss more than 2-3 doses then I feel incredibly low for about a week but then pick up again."

Chacha753 March 27, 2017

For Panic Disorder: "This medication saved my life! I've only been taking it for almost 2 weeks but I was thrilled at the fast response I had to it! I've literally tried almost every other antidepressant without much success for over 20 years - for my debilitating panic disorder/GAD/depression. Thank you to the Dr who started me on this recently while I was hospitalized for a suicide attempt. I can now leave my home without any fear or anxiety; my panic attacks/panic are literally gone! I feel like a new person! The only side effects I've had so far are dry mouth/dry eyes and a bit of tachycardia. It also helps me sleep for once; I take it at bedtime. I was titrated up to the 100mg dose once at bedtime. I cannot emphasize enough how happy I am to have this!"

Dmorris3672 March 12, 2017

For Panic Disorder: "I have had awesome results with this drug, after going through a rough year being taken on & off of medications that almost ruined my life. My Dr has been sending me to check my blood levels & they seem to keep going up. I was taking 200 mg at night & he dropped it to 175mg. It took 3 weeks to start feeling withdrawal & it was awful. He then increased it back to 200 mg & my imipramine levels are higher then they have ever been. I am scared he is going to reduce or try to put me on another drug. Anyone ever had problems with blood levels of imipramine?"

Species kkrittv February 12, 2017

For Panic Disorder: "Did not work only made me very tired"

Not a good choice December 6, 2016

For Panic Disorder: "Very bad side effects on day 6 and I have to stop taking. Nausea all the time. Headaches. Dizziness. Nervousness. Tired constantly. On very low dose."

Cherylannj · Taken for less than 1 month September 17, 2016

For Panic Disorder: "Helps the panic disorder. But I havent slept in 3 days. Is this medication a stimulate? ?????"

Primrose2016 September 14, 2016

For Pain: "Taking at a very low dose to help me sleep as I have fibromyalgia related to arthritis. I tried two other drugs before this one and both have me extremely bad nightmares. I have found that I don't get nightmares with this one. Within an hour of taking, I am solid asleep virtually all night. I don't get foggy the next day. I really haven't had any side effects except for a slightly dry mouth, but I am on 10mg."

shipster · Taken for 1 to 6 months August 4, 2016

For Depression: "works very slow. it took months for an improvement not weeks and the improvement is very limited, also had semen leakge as side effect after 125mg"

mom483 · Taken for 10 years or more June 26, 2016

For Depression: "I was prescribed imipramine for depression. It worked very well for years! BUT... it made me a diabetic with peripheral neuropathy. When I was originally given the medication I was told it would increase my appetite. It did - a LOT! It also raised my glucose levels to astronomical levels (400-500). My A1c was between 10 and 11. Over time, it damaged my nerves. I didn't realize this until my feet began to burn. After slowly decreasing imipramine by 5 mg per week until completely coming off it, my feet were unbearable. The pain was constant. I couldn't walk, or have anything on my feet. I would sleep with my blankets folded up and my feet hanging off the bed. I would soak my feet in ice water to alleviate the burning and pain."

SextonMomo April 22, 2016

For Panic Disorder: "I began having panic and anxiety attacks when I was 25. I suffered with them for about 10 years and a new doctor put me on imipramine. I've had only one or two anxiety attacks since and its been years. I'm now 72 and I haven't noticed any bad reactions to the medication."

Kam I · Taken for less than 1 month February 17, 2016

Tofranil (imipramine) for Depression: "Waste of 75 bucks. My mood only increased slightly, and in exchange I got terrible bouts of dizziness and vertigo. Most of the time I felt like I'd been shot with a tranquilizer dart. Horrible experience. After only a week or so, I started to get nausea as well, so I had to stop. I regret spending money on this med."

angie40dia December 18, 2015

For Depression: "I was prescribed this med for depression which is also effective at bedtime for sleep & fibromyalgia pain. The pain improved significantly and I felt more rested the next day. A dry mouth is the main side effect that is noticeable. This drug is very helpful."

truetina22 · Taken for 6 months to 1 year June 7, 2015

For Pain: "I was prescribed this medication for chronic widespread musclepain(fibromyalgia) and neuropathic pain,and allodynia all over plus vulvodynia. It does take the edge off,and the pain is not as intense as it used to be, but still continuing sadly. It did take away my sleep paralysis episodes,and sleep hallucinations, amazing for sleep too.Its a great drug, its the only one I can tolerate, I tried amytriptyline and all the SSRI's but the side effects been horrendous,and had a devastating effect on my functioning.The only effects imipramine have on me is some dizziness and drowsiness during the day, fast heart rate, and mild loss of libido, but other than these I feel its very useful with pain and sleep.The first few days expect nausea,and somnolence."

Missy33 June 4, 2015

For Depression: "Only been on it about 6 weeks and only up to 30mg. Moods are a little better so far but insomnia hello. I'm lucky to get 3 or 4 hours a nite I don't get how all of you sleep. I used to fall right asleep with my topamax at nite. Now he has me taking my gabapentin, topamax and imipramine at bedtime optional Ativan too but then I wake up groggy defeating the purpose of great mood in the am. Hum maybe my meds don't play nice together at nite lol. I do get the dry mouth I really hate that but it has improved my morning moods which is what we were going for. I do have anxiety and it doesn't help with a quick onset. I am hopeful for this med as I have tried just about everything out there!"


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