Imipramine and Weight Gain: What Users Say

• Tai...
• September 27, 2019

For Pain "I was suffering from 'atypical facial pain' for two years, which was absolutely excruciating (every other day). I held off taking a medicine such as this because I was concerned about the impact it may have on my (male) fertility. In the end, I succumbed because the pain was just too much. 80 mg - 40 in the morning and 40 in the evening - has taken away the pain. I switched between this and amitriptyline for a while because this one does have side effects. I have an endlessly dry mouth, so I have to drink a lot of water. Urinating can also be a challenge, but the sheer amount of water I drink offsets this problem somewhat. Amitriptyline worked equally well, but it was more sedating. Imipramine makes it more difficult to sleep at night, but it doesn't send me to sleep during the day. Amitriptyline is worse for weight gain, in my experience, and both are equally bad for libido. Neither has been good for my anxiety. On the whole, I am extremely grateful to imipramine though."

• Joc...
• January 27, 2011

For Irritable Bowel Syndrome "Great for irritable bowel syndrome, but I've gained a lot of weight."

• Dun...
• April 17, 2008

For Pain "I have been on imipramine for over 2 years and found it good for pain relief combined with gabapentin. The only problem I have encountered is weight gain, as it tends to increase my appetite."

• sti...
• Taken for 6 months to 1 year
• August 25, 2019

For Depression "Imipramine was ineffective for my depression and made me fat. But when I tried reducing it from 150 mg to 125 mg, I became even more depressed."