Imipramine User Reviews & Ratings (Page 2)

• Zak...
• September 5, 2019

For ADHD "My doctor gave me imipramine for my OCD. Within 8 days of starting this medicine, I could pick up a book and read it in 45 minutes. Astounding, since I've had terrible difficulty with reading my entire life. Sadly, I had to stop taking the medication after two weeks due to a strong anticholinergic effect that was causing pretty severe bladder pain and urinary retention. I feel this tricyclic unlocked an extra 20 IQ points that were previously inaccessible to me. OTHER info, my visualization abilities were truly astounding while on imipramine that first time. When I thought of something, I could ask myself to visualize an 'abstract geometric representation,' for instance, of whatever I was thinking of. And POOF, a bright neon-like abstract shape would appear in front of me. And oddly enough, I 'understood' its relationship to the original idea."

• Sul...
• Taken for 1 to 2 years
• November 13, 2017

For Depression "I was on imipramine for a little over a year, after trying every other antidepressant known to man. At first, I noticed a major change. It was the best I had felt in years. I was back to doing things that I used to do and felt great. It also helped me to sleep at night. The effects of the med started to decrease, so we increased the dose until I was eventually on 100 mg a day. That's when the side effects started. I went in for a routine doctor visit, and my resting heart rate was 130. Of course, panic set in, and I had a bunch of tests ran on my heart, everything was normal. The only thing different was the increase in imipramine. It caused me tachycardia. So now, I am in the process of weaning off of it. Onto something else."

• Tai...
• September 27, 2019

For Pain "I was suffering from 'atypical facial pain' for two years, which was absolutely excruciating (every other day). I held off taking a medicine such as this because I was concerned about the impact it may have on my (male) fertility. In the end, I succumbed because the pain was just too much. 80 mg - 40 in the morning and 40 in the evening - has taken away the pain. I switched between this and amitriptyline for a while because this one does have side effects. I have an endlessly dry mouth, so I have to drink a lot of water. Urinating can also be a challenge, but the sheer amount of water I drink offsets this problem somewhat. Amitriptyline worked equally well, but it was more sedating. Imipramine makes it more difficult to sleep at night, but it doesn't send me to sleep during the day. Amitriptyline is worse for weight gain, in my experience, and both are equally bad for libido. Neither has been good for my anxiety. On the whole, I am extremely grateful to imipramine though."

• The...
• Taken for 10 years or more
• October 22, 2019

For Pain "I suffered from severe back pain and nerve damage from 2003 onwards. Chronic pain combined with trying to keep working, traveling the world, and family life led to depression. After visiting my GP, he sent me to a psychiatrist who started me on imipramine, 100 mg at night. It certainly improved things for me. Life got better. Combined with cortisone injections into the spine, I could now tolerate the pain, and life improved. I am now much better and quite active, and pain is less frequent. I’m on a mission to reduce the dosage, and I’m now down to 35 mg at night. I blame my high blood pressure and skin irritations on my shins on the imipramine, but that’s to be proven yet. One thing, don’t try to come off it yourself or play with your dosage yourself. I foolishly did that for a few weeks a few years ago, and one day I thought I was having a stroke or vertigo. I was in total bits with electric shock-like symptoms and a fear of going to pass out. Very scary."

• Aug...
• Taken for 1 to 2 years
• August 28, 2020

For ADHD "Imipramine in combination with a small dose of Ritalin (methylphenidate) works very well for me. Remember, imipramine and its metabolites have a strong effect on norepinephrine, working similarly to atomoxetine, which is FDA approved for ADHD."

• Mis...
• June 4, 2015

For Depression "Only been on it about 6 weeks and only up to 30 mg. Moods are a little better so far, but insomnia, hello. I'm lucky to get 3 or 4 hours a night. I don't get how all of you sleep. I used to fall right asleep with my Topamax at night. Now he has me taking my gabapentin, Topamax, and imipramine at bedtime, optional Ativan too, but then I wake up groggy, defeating the purpose of a great mood in the AM. Hmm, maybe my meds don't play nice together at night, lol. I do get the dry mouth, I really hate that, but it has improved my morning moods, which is what we were going for. I do have anxiety, and it doesn't help with a quick onset. I am hopeful for this med as I have tried just about everything out there!"

• Ble...
• Taken for 1 to 6 months
• February 17, 2021

For Enuresis "I started imipramine a few months ago for both depression and enuresis (two birds with one stone!) and have noticed positive changes in both areas. It completely eliminated the enuresis, and my mental health is better than it has been in years. I have not noticed any negative side effects!"

• Anonymous
• August 2, 2009

Imipramine for Depression "At first, this medicine seemed great. Was taking it for depression and generalized anxiety disorder. After a week on the lowest dose, I started having bad side effects. I was shaving one morning and noticed my face, lips, and arm felt numb. Doctor reduced my dosage to 10 mg, that worked okay for a week, then same side effects."

• Dai...
• November 14, 2022

For Irritable Bowel Syndrome "I have chronic IBS-diarrhea, which started in my twenties. I get severe, severe nausea when I get an attack. It is so bad I think I have to go to the hospital. The nausea is the worst part of my IBSd. My whole body feels sick. After years of horrible suffering, I was put on imipramine, and it gave me back my life. I was 30 when I started it. I am now 61. I had to modify my lifestyle in conjunction with the imipramine, I watch what I eat, avoid onions at all costs, and I don’t drink. My attacks were daily, and now they are sporadic. Rare. But when I try to go off the imipramine, they come back, so I am still on it. But it is manageable now. When it comes, I take a Tylenol right away and use my hot water bottle. If it is a bad one, I will chew a bit of Pepto Bismol. Imipramine does have side effects, but the benefits outweigh them."

• Ohi...
• February 12, 2019

For Irritable Bowel Syndrome "I was placed on Imipramine, 10 mg. Taken at bedtime. The 3rd week after starting it, I began having nerve-like pain and burning down both legs into my feet, lower back pain and muscle spasms in my back and legs. I couldn't sleep and was irritable. Three days later, I started noticing balance and coordination difficulties. It was so bad I was finding it hard to stand and walk, often falling into walls. I was dizzy and shaky. My cognitive abilities were diminished. Days later, close to the end of week 3 of being on the Imipramine, I began to have nerve-like pain in my arms and hands, my lips and tongue were numb, and my lips were peeling excessively. I was sure it was the Imipramine by then and stopped taking it at week 4. Thirty hours after my last dose, I noticed a slight improvement of side effects. Four to five days later, all the side effects were greatly reduced, and by seven days after the last dose of the Imipramine, all symptoms had stopped and I began to feel like my normal self. I never noticed that it helped the IBS."

• Kat...
• Taken for 6 months to 1 year
• August 3, 2012

For ADHD "I have insomnia and fibromyalgia. The pain from the fibromyalgia is worsened when I can't sleep well. My doctor prescribed this medication to me mainly for better sleep. He said that this medication was one of the first non-stimulant medications for ADHD (which I've been diagnosed with), and so it may help with my ADHD symptoms as well. When I first started taking this, I felt nauseated all the time for about 2 1/2 weeks. Once that passed, I felt like I really was sleeping better. About 2 months in, I started having vivid hallucinations, and 6 months in, I started having kidney pain and urinary tract problems. I'm now trying to wean myself off of it because sadly the side effects are outweighing the better sleep."

• ita...
• Taken for 1 to 6 months
• November 8, 2019

For Panic Disorder "- First 4 days of imipramine @50mg I would have odd outer body-type experiences just before falling asleep, created more panic. - 2nd and 3rd week I could feel my panic fighting against the medication, I thought it may be starting to work. By the second month I was going to the bathroom only once a week, yes, the constipation is real. I had a full body cold shiver which took up 90% of my day, restless leg while trying to sleep, problems urinating, and my anxiety was back. You would think only on a month and a half I can stop, NO, had to taper off, next, everyone will react differently."

• Ben...
• January 8, 2009

For Night Terrors "I take Imipramine for cataplexy and night terrors. For cataplexy, Imipramine is by far the most effective treatment my doctor has tried, as it has eliminated about 70% of the attacks. As for night terrors, they are completely gone. However, if I take a nap during the day, I will have nightmares about half the time. I take 150 mg just before bed. The first couple of months, I was faced with some side effects. If I didn't go to bed right after taking the medicine, I would be in a dazed state and could fall asleep standing up - that is gone. Erectile dysfunction and stuttering were also present in the first 90 days or so. Both have disappeared. This is a drug you must give a little time before you see the benefits."

• OnT...
• Taken for less than 1 month
• November 12, 2022

For ADHD "On my last antidepressant, I was sleeping for 12 hours and still felt tired (hypersomnia). Now I'm on imipramine, I'm sleeping for 6-8 hours and am waking up early. My insomnia has vanished, and I feel well-rested on this drug. I haven't felt so well slept in many years. I felt low the first couple of days, but that soon evened out. Mood-wise, it's definitely improved. No longer uneasy/queasy. I think I'm going to stay on this med. My impulsivity has reduced, and I feel much more level-headed. I drink way more water on imipramine. Appetite-wise, I'm eating slightly less than I used to, which is great because I'm overweight."

• mom...
• Taken for 10 years or more
• June 26, 2016

For Depression "I was prescribed imipramine for depression. It worked very well for years! But... it made me a diabetic with peripheral neuropathy. When I was originally given the medication, I was told it would increase my appetite. It did - a lot! It also raised my glucose levels to astronomical levels (400-500). My A1c was between 10 and 11. Over time, it damaged my nerves. I didn't realize this until my feet began to burn. After slowly decreasing imipramine by 5 mg per week until completely coming off it, my feet were unbearable. The pain was constant. I couldn't walk or have anything on my feet. I would sleep with my blankets folded up and my feet hanging off the bed. I would soak my feet in ice water to alleviate the burning and pain."

• Ver...
• Taken for less than 1 month
• March 16, 2022

For Panic Disorder "Within the first day, I noticed a large improvement in my panic disorder as well as my ADHD, which I am already being treated for with Zenzedi, but that has been getting worse as my panic disorder began resurfacing from years past due to personal circumstances. Very effective medicine for panic disorder. Also, for PTSD, I found relief."

• Ken...
• Taken for less than 1 month
• April 4, 2021

For Depression "I started on imipramine, two 25 mg per day, and it has been 4 days on it. Immediately, I noticed a considerable decline in my sex drive. This was my experience, I've used bupropion, which was great! It's worth discussing with your psychiatrist. I have ADHD and comorbid depression, probably anxiety too. All the best with your treatment."

• Mja...
• Taken for less than 1 month
• November 12, 2019

For Depression "I came off Lexapro thinking that imipramine would be better since it affects 3 neurotransmitters: dopamine, serotonin, norepinephrine. But I had another thing coming. It is the worst. More side effects. The effect is low and sluggish. Always makes you sleepy. It destroyed my appetite. I can't even eat for days. My energy levels depleted significantly. I am just gonna give it an extra one week, if it doesn't work, I'll request a new medication, 'cause 8 days into this drug, I feel like I have lost it all."

• Dmo...
• March 12, 2017

For Panic Disorder "I have had awesome results with this drug, after going through a rough year being taken on and off of medications that almost ruined my life. My doctor has been sending me to check my blood levels, and they seem to keep going up. I was taking 200 mg at night, and he dropped it to 175 mg. It took 3 weeks to start feeling withdrawal, and it was awful. He then increased it back to 200 mg, and my imipramine levels are higher than they have ever been. I am scared he is going to reduce or try to put me on another drug. Anyone ever had problems with blood levels of imipramine?"

• Ble...
• Taken for 1 to 6 months
• February 17, 2021

For Depression "I started imipramine a few months ago for both depression and enuresis (two birds with one stone!) and have noticed positive changes in both areas. It completely eliminated the enuresis, and my mental health is better than it has been in years. I have not noticed any negative side effects!"

• Ray...
• Taken for 1 to 2 years
• May 11, 2023

For Panic Disorder "Suffered from panic attacks and was given imipramine for treatment… it worked and stopped the attacks, giving me time to learn how to deal with them. I had to stop as I was unable to take the medicine and hold a CDL. I have been free for many years, and the drug worked as expected."

• Mic...
• October 17, 2017

For Depression "This drug took an awfully long time to work. I hadn't been able to notice its subtle effects until about 2 months into treatment. It does lift your mood up by a tiny fraction, is great for general anxiety, and it sparks up your motivation a bit. I had been on this medication alone for no avail, but when I paired it with an SSRI (Zoloft), it made a huge difference. I recommend this combination for the treatment of depression."

• Anonymous
• Taken for 1 to 6 months
• October 19, 2023

For Night Terrors "This medicine works great for night terrors. I have suffered from night terrors for over 25 years. I took venlafaxine before and that seemed to work as well. I didn't like the side effects with that medicine. Imipramine, the only side effect I get is sweating sometimes during the daytime mostly. I am taking 10mg daily at night and this has eliminated my night terrors and I was experiencing them about 3-4 times a week. I would recommend this medicine."

• ano...
• Taken for 1 to 6 months
• July 24, 2017

For Depression "25 mg, once a day at night. For the first 7-8 weeks of taking this medication, there was no positive effect on my mood, around week 3/4, my mood was noticeably worse. During the 7-8 week period, I constantly felt disconnected and lacked any sort of motivation or energy to engage in any activity that involved thinking, especially social situations. I would constantly have a dry mouth and dry eyes, and in addition, I also had trouble urinating in the morning, and when standing up, I would feel light-headed and dizzy for a few seconds, this was worse if I had been lying down. However, now my mood is much more stable and the side effects are gone, but if I miss more than 2-3 doses, then I feel incredibly low for about a week but then pick up again."

• Amy...
• Taken for 1 to 6 months
• June 2, 2020

Imipramine for Depression "Tofranil made me painfully constipated, very nervous, irritable. Between doses, I'd get extremely weepy and emotionally distraught. It was the only time in my life that I felt life was too hard. When I started experiencing heart palpitations, I stopped taking it. I have CPTSD and borderline."