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Comparing Venlafaxine vs Vortioxetine

Venlafaxine

Vortioxetine

Venlafaxine is an antidepressant that may cause a discontinuation syndrome if abruptly stopped after long-term administration. Prescribed for Major Depressive Disorder, Anxiety, Depression, Autism,... more

Prescribed for Major Depressive Disorder, Depression. vortioxetine may also be used for purposes not listed in this medication guide.

Prescription only

Prescription only

Ratings & Reviews

Recent helpful reviews
6.8
1597 Reviews

For Depression I just started taking it within the last few days, and I have been so nauseated since then. My head feels a little cloudy, too. I'm really hoping those side effects go away soon.

7
Danielle34

For Depression Well. I started on 75mg a day of venzip XL. They elevated my depression hole I was in. My brain did feel doped up for the 1st week, had headaches and took a couple of hours each night to get to sleep. So I decided to stop taking them. I had the best 2 nights sleep after that I have ever had. Just got my National Nealth Service CBT therapy session a week into taking tablets and she suggested taking 1 every other day. So only 2 weeks into my tablets they are stabilising. Not as much headaches, not feeling too doped up and still can't fall asleep though I'm waiting for an appointment to see my gp for a follow up on them. Having problem trying to see same doctor as he's a fill in. Hope my suggestion help other. All I say is stick at them Start on a very low dosage and increase amount slowly. Best of luck.

7
Adrienne
6.1
875 Reviews

For Depression I've had zero nausea, but zero sex drive and I have a hard time concentrating at work. I've been taking 20 mg for about 6 weeks. I take it at bedtime. I have been very sluggish and have gained about 10 pounds. I also have terrible gas so I have to take gas pills daily. It has helped with my depression, but my job is suffering because I cannot concentrate at all. I'm thinking of asking my doctor to change my med because I will get fired soon if I keep this up! I no longer want to kill myself, but soon I will be obese, unemployed and sleepy. Then I will be more depressed...

6
SuzyQ72

For Depression Hello: I have taken 5mg doses once a day for the past 2 1/2 weeks for High blood pressure and stress. I noticed no effect and had none of the bad side effects I've heard of here. One thing - I do think I am dreaming more. Not nightmares but very vivid dreams. I may be a little calmer during the day but I can hardly notice *any* changes. I will stay with this for a while longer and see what happens.

6
Stork1

View all 1597 reviews

View all 875 reviews

Drug Class

Side Effects

Commonly reported side effects include: anorgasmia, asthenia, constipation, dizziness, drowsiness, insomnia, nausea, nervousness, headache, anorexia, decreased appetite, delayed ejaculation, diaphoresis, and xerostomia.

See the full venlafaxine side effects document.

Commonly reported side effects include: diarrhea, male sexual disorder, and nausea.

See the full vortioxetine side effects document.

Pricing and Coupons

* Prices are without insurance
Quantity 100 each
Dosage 150 mg
Per Unit* $0.38 - $2.83
Cost* $38.25 - $283.05
View all venlafaxine prices

We could not find an exact match for this medicine. Try searching the Price Guide directly.

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Generic Availability

Yes (this medicine)

No

Dosage Form(s) Available
  • Oral capsule, extended release
  • Oral tablet
  • Oral tablet, extended release
 N/A

Brand Names
Effexor, and Effexor XR Trintellix

Half Life

The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value.

4 hours

66 hours

CSA Schedule**

View glossary of terms.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category
C
Category C Risk cannot be ruled out

See the full Pregnancy Warnings document.
C
Category C Risk cannot be ruled out

See the full Pregnancy Warnings document.

FDA Alerts

FDA Alerts (5)

FDA Alerts (1)

Drug Interactions

A total of 1137 drugs are known to interact with venlafaxine:

  • 268 major drug interactions (1835 brand and generic names)
  • 859 moderate drug interactions (4904 brand and generic names)
  • 10 minor drug interactions (50 brand and generic names)

A total of 627 drugs are known to interact with vortioxetine:

  • 226 major drug interactions (1722 brand and generic names)
  • 398 moderate drug interactions (1994 brand and generic names)
  • 3 minor drug interactions (9 brand and generic names)

Alcohol/Food/Lifestyle Interactions
  • Alcohol can increase the nervous system side effects of venlafaxine such as dizziness, drowsiness,... more
  • Alcohol can increase the nervous system side effects of vortioxetine such as dizziness, drowsiness,... more

Disease Interactions

First Approval Date

December 28, 1993

September 30, 2013

WADA Class

View World Anti-Doping Agency classifications.

N/A

N/A

More Information

Consumer Resources

Professional Resources

Related Treatment Guide

** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

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