Comparing Simvastatin vs Zetia
| Simvastatin | Zetia (ezetimibe) |
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| Simvastatin | Zetia (ezetimibe) |
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Prescription only
Simvastatin is effective at lowering cholesterol; however, it may cause muscle pain, particularly at higher dosages. Should not be used by people with active liver disease or in women planning a... View more |
Prescription only
Zetia may be used to lower cholesterol alone or in combination with a statin or fibrate. It has few reported side effects and few drug interactions. It is effective at lowering intestinal absorption... View more |
Related suggestions High Cholesterol
High Cholesterol, Familial Heterozygous
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| More about Simvastatin | More about Zetia (ezetimibe) | ||||||||||||||||
| Ratings & Reviews | |||||||||||||||||
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Simvastatin has an average rating of 4.8 out of 10 from a total of 131 ratings on Drugs.com. 30% of reviewers reported a positive effect, while 48% reported a negative effect. |
Zetia has an average rating of 4.3 out of 10 from a total of 76 ratings on Drugs.com. 30% of reviewers reported a positive effect, while 57% reported a negative effect. |
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| Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified. | |||||||||||||||||
View all Simvastatin side effects |
View all Zetia side effects |
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| Drug Class | |||||||||||||||||
| Generic Availability | |||||||||||||||||
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Lower cost generic |
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| Pricing and Coupons * Prices are without insurance | |||||||||||||||||
View all Simvastatin prices |
View all Zetia prices |
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| Dosage Forms | |||||||||||||||||
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| Brand Names | |||||||||||||||||
| FloLipid, Zocor |
N/A |
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| Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value. | |||||||||||||||||
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N/A |
22 hours |
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| CSA Schedule 1 View glossary of CSA terms | |||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | |||||||||||||||||
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Category X
Not for use in pregnancy
See the full pregnancy warnings document. |
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
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| Drug Interactions | |||||||||||||||||
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A total of 336 drugs are known to interact with Simvastatin:
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A total of 68 drugs are known to interact with Zetia:
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| Alcohol/Food/Lifestyle Interactions | |||||||||||||||||
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No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
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| Disease Interactions | |||||||||||||||||
| First Approval Date | |||||||||||||||||
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December 23, 1991 |
October 25, 2002 |
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| WADA Class View classifications | |||||||||||||||||
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N/A |
N/A |
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| More Information | |||||||||||||||||
| Patient Resources | |||||||||||||||||
| Professional Resources | |||||||||||||||||
| Related Treatment Guide | |||||||||||||||||
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1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
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Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.