Zetia Side Effects
Generic name: ezetimibe
Note: This document contains side effect information about ezetimibe. Some dosage forms listed on this page may not apply to the brand name Zetia.
Applies to ezetimibe: oral tablets.
Side effects include:
Ezetimibe (the active ingredient contained in Zetia) monotherapy: Upper respiratory tract infection, diarrhea, arthralgia, sinusitis, pain in extremity, fatigue, influenza.
Ezetimibe in fixed combination with simvastatin: Headache, increased ALT, myalgia, upper respiratory tract infection, diarrhea.
Ezetimibe in fixed combination with bempedoic acid: Upper respiratory tract infection, muscle spasms, hyperuricemia, back pain, abdominal pain or discomfort, bronchitis, extremity pain, anemia, increased hepatic enzymes, diarrhea, arthralgia, sinusitis, fatigue, influenza.
For Healthcare Professionals
Applies to ezetimibe: oral tablet.
General
The most frequently reported side effects were upper respiratory tract infection, diarrhea, arthralgia, sinusitis, and pain in extremity.[Ref]
Gastrointestinal
Common (1% to 10%): Abdominal pain, diarrhea, flatulence
Uncommon (0.1% to 1%): Dyspepsia, gastroesophageal reflux disease, nausea
Postmarketing reports: Pancreatitis, constipation[Ref]
Immunologic
Postmarketing reports: Anaphylaxis[Ref]
Musculoskeletal
Common (1% to 10%): Arthralgia, pain in extremity
Uncommon (0.1% to 1%): Muscle spasms, neck pain
Postmarketing reports: Myalgia, myopathy, rhabdomyolysis[Ref]
Respiratory
Common (1% to 10%): Upper respiratory tract infection, sinusitis
Uncommon (0.1% to 1%): Cough
Postmarketing reports: Dyspnea[Ref]
Hypersensitivity
Postmarketing reports: Hypersensitivity reaction[Ref]
Hepatic
Uncommon (0.1% to 1%): Gamma-glutamyltransferase increased, liver function test abnormal, AST/ALT increased
Postmarketing reports: Hepatitis, liver transaminases increased, cholelithiasis, cholecystitis[Ref]
Hematologic
Postmarketing reports: Thrombocytopenia[Ref]
Nervous system
Uncommon (0.1% to 1%): Dizziness
Postmarketing reports: Paresthesia, headache[Ref]
Psychiatric
Postmarketing reports: Depression[Ref]
Cardiovascular
Uncommon (0.1% to 1%): Hot flush, hypertension[Ref]
Dermatologic
Postmarketing reports: Angioedema, rash, urticaria, erythema multiforme[Ref]
Metabolic
Uncommon (0.1% to 1%): Appetite decreased[Ref]
Other
Common (1% to 10%): Fatigue, influenza
Uncommon (0.1% to 1%): Chest pain, pain, creatine phosphokinase increased
Postmarketing reports: Asthenia[Ref]
Frequently asked questions
- Is it a statin drug/medication?
- Does Zetia (ezetimibe) cause memory loss?
- Is this better than a statin?
- Can Zetia (ezetimibe) cause liver damage?
- Does it affect blood pressure?
- How does it work to lower cholesterol?
- Can it cause weight gain or loss?
- What happens if you stop taking it?
- When should you take it?
More about Zetia (ezetimibe)
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- Drug class: cholesterol absorption inhibitors
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Related treatment guides
References
1. Product Information. Zetia (ezetimibe). Schering-Plough Corporation. 2002.
2. Cerner Multum, Inc. UK Summary of Product Characteristics.
3. Cerner Multum, Inc. Australian Product Information.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.
