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When is the best time to take Zetia?

Medically reviewed by Melisa Puckey, BPharm. Last updated on Oct 11, 2022.

Can I take Zetia at the same time as my other cholesterol medications?

Official answer


There is no best time to take Zetia, as it works exactly the same whether you take it in the morning, afternoon or evening.
Zetia is taken once a day, at the same time each day and it can be taken with or without food. It is important to choose a time to take it that is most convenient for you and when you are most likely to remember to take it.

Can I take Zetia at the same time as my other cholesterol medications?

Zetia is a cholesterol lowering medication and is sometimes prescribed to be taken with other cholesterol medications.
Zetia can be taken at the same time as these cholesterol lowering medications:

  • fenofibrate
  • atorvastatin
  • lovastatin
  • simvastatin
  • pravastatin
  • fluvastatin.

Zetia needs to be taken at a different time from these cholesterol lowering medications:

  • cholestyramine
  • colestipol
  • colesevelam.

If you have taken cholestyramine, colestipol, or colesevelam you need to wait at least 4 hours before taking Zetia.

If you have taken Zetia you need to wait 2 hours before taking cholestyramine, colestipol, or colesevelam.

Bottom line:
Zetia can be taken:

  • at anytime of the day
  • as long as it is the same time each day
  • with or without food.


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