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Can ezetimibe be used with statin drugs?

Medically reviewed by Melisa Puckey, BPharm. Last updated on Nov 15, 2020.

Can you take ezetimibe with statin drugs eg: simvastatin, atorvastatin, rosuvastatin, pravastatin, fluvastatin?

Official Answer


Yes, ezetimibe can be taken with statin drugs.

Ezetimibe and statin drugs are both used to reduce high cholesterol levels.
They lower cholesterol in different ways:

  • Ezetimibe blocks cholesterol being absorbed from the small intestine
  • Statins reduce the amount of cholesterol and lipoproteins that our bodies produce, by inhibiting an enzyme called HMG-CoA reductase (3-hydroxy-3-methylglutaryl coenzyme A reductase). Statins also act to increase the number of LDL receptors on liver cells which means more LDL-cholesterol is absorbed out of the bloodstream and broken down.

Ezetimibe and statin drugs are often prescribed together as they have a complementary effect due to the fact that they reduce blood cholesterol levels different ways.


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