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Can ezetimibe be used with statin drugs?

Can you take ezetimibe with statin drugs eg: simvastatin, atorvastatin, rosuvastatin, pravastatin, fluvastatin?

Medically reviewed by Melisa Puckey, BPharm. Last updated on Nov 15, 2020.

Official Answer

by Drugs.com

Yes, ezetimibe can be taken with statin drugs.

Ezetimibe and statin drugs are both used to reduce high cholesterol levels.
They lower cholesterol in different ways:

  • Ezetimibe blocks cholesterol being absorbed from the small intestine
  • Statins reduce the amount of cholesterol and lipoproteins that our bodies produce, by inhibiting an enzyme called HMG-CoA reductase (3-hydroxy-3-methylglutaryl coenzyme A reductase). Statins also act to increase the number of LDL receptors on liver cells which means more LDL-cholesterol is absorbed out of the bloodstream and broken down.

Ezetimibe and statin drugs are often prescribed together as they have a complementary effect due to the fact that they reduce blood cholesterol levels different ways.

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