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Can ezetimibe be taken with statin drugs like atorvastatin?

Medically reviewed by Melisa Puckey, BPharm. Last updated on Nov 7, 2022.

Official answer


Yes, ezetimibe can be taken with statin drugs.

Ezetimibe and statin drugs are both used to reduce high cholesterol levels.
They lower cholesterol in different ways:

  • Ezetimibe blocks cholesterol being absorbed from the small intestine
  • Statins reduce the amount of cholesterol and lipoproteins that our bodies produce, by inhibiting an enzyme called HMG-CoA reductase (3-hydroxy-3-methylglutaryl coenzyme A reductase). Statins also act to increase the number of LDL receptors on liver cells which means more LDL-cholesterol is absorbed out of the bloodstream and broken down.

Ezetimibe and statin drugs are often prescribed together as they have a complementary effect due to the fact that they reduce blood cholesterol levels different ways.

Statin drugs include: simvastatin, atorvastatin, rosuvastatin, pravastatin, fluvastatin?


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